Ulipristal acetate: A new emergency contraceptive that is safe and more effective than levonorgestrel

Women's Health

Volumn 7, Issue 1, 2011, Pages 9-17

  Fine, Paul M ^a  

^a NONE   (United States)

Author keywords

emergency contraception; levonorgestrel; ulipristal acetate; unprotected intercourse

Indexed keywords

DRUG METABOLITE; ELLA; ESTROGEN; ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS LEVONORGESTREL; ETHINYLESTRADIOL PLUS NORGESTREL; GESTAGEN; JOLESSA; LEVONORGESTREL; LOW OGESTREL; LUTERA; NEXT CHOICE; ORAL CONTRACEPTIVE AGENT; PLAN B ONE STEP; POSTCOITUS CONTRACEPTIVE AGENT; SRONYX; ULIPRISTAL; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ARTICLE; BREAST TENDERNESS; CLINICAL TRIAL; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG ABSORPTION; DRUG BINDING; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG EXCRETION; DRUG HALF LIFE; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; DRUG SURVEILLANCE PROGRAM; DRUG TOLERABILITY; DYSMENORRHEA; EMERGENCY CONTRACEPTION; FATIGUE; HEADACHE; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; LOWER ABDOMINAL PAIN; NAUSEA; OFF LABEL DRUG USE; OVARY CYCLE; OVULATION INHIBITION; POSTMARKETING SURVEILLANCE; PREGNANCY OUTCOME; PREGNANCY RATE; RISK FACTOR; RISK REDUCTION; SEXUAL INTERCOURSE; SINGLE DRUG DOSE; SPOTTING; UNPLANNED PREGNANCY; UNSAFE SEX; UNSPECIFIED SIDE EFFECT; UPPER ABDOMINAL PAIN; VAGINA BLEEDING; VOMITING; WOMEN'S HEALTH;

CLINICAL TRIALS AS TOPIC; CONTRACEPTION, POSTCOITAL; CONTRACEPTIVES, POSTCOITAL; FEMALE; HUMANS; LEVONORGESTREL; NORPREGNADIENES; OVULATION INHIBITION; PREGNANCY; TIME FACTORS; TREATMENT OUTCOME;

EID: 78650642310     PISSN: 17455057     EISSN: 17455065     Source Type: Journal    
DOI: 10.2217/whe.10.63     Document Type: Article

References (14)

1. Finer LB, Henhaw SK: Disparities in rates of unintended pregnancy in the United States, 1994 and 2001. Perspect. Sex. Reprod. Health 38, 90-96 (2006).
2. Mosher WD, Jones J: Use of contraception in the United States: 1982-2008. National Center for Health Statistics. Vital Health Stat. 23(29), 1-44 (2010).
3. WHO. Task Force on Postovulatory Methods of Fertility Regulation. Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Lancet 352, 428-433 (1998).
4. Piaggio G, von Hertzen H, Graimes DA, Van Look PF: Timing of emergency contraception with levonorgestrel or the Yuzpe regimen. Task Force on Postovulatory Methods of Fertility Regulation. Lancet 353, 721 (1999).
5. Croxatto HB, Brache V, Pavez M et al.: Pituitary-ovarian function following the standard levonorgestrel emergency contraceptive dose or single 0.75 mg dose given on the days preceding ovulation. Contraception 70, 442-450 (2004).
6. Brache V, Cochon L, Jesam C et al.: Immediate preovulatory administration of 30 mg ulipristal acetate significantly delays follicular rupture. Hum. Reprod. 25(9), 2256-2263 (2010).
7. NICHD Drug Evaluation Report: Anti- Clauberg test. HRA 2914-450. April 26, (1994).
8. Creinin MD, Schlaff W, Archer DF et al.: Progesterone receptor modulator for emergency contraception: a randomized controlled trial. Obstet. Gynecol. 108, 1089-1097 (2006).
9. Trussell J, Rodriguez G, Ellertson C: New estimates of the effectiveness of the Yuzpe regimen of emergency contraception. Contraception 57, 363-369 (1998).
10. Fine P, Mathe H, Ginde S, Cullins V, Morfesis J, Gainer E: Ulipristal acetate taken 48-120 hours after intercourse for emergency contraception. Obstet. Gynecol. 115, 257-263 (2010).
11. Glasier AF, Cameron ST, Fine PM et al.: Ulipristal acetate versus levonorgestrel for emergency contraception: a randomized non-inferiority trial and meta-analysis. Lancet 375, 555-562 (2010).
12. Croxatto HB, Brache V, Pavez M et al.: Pituitary-ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75-mg dose given on the days preceding ovulation. Contraception 70, 442-450 (2004).
13. Stirling A, Glasier A: Estimating the efficacy of emergency contraception - how reliable are the data? Contraception 66, 19-22 (2002).
14. Stratton P, Levens ED, Hartog B et al.: Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914. Fertil. Steril. 93(6), 2035-2041 (2010).