Progesterone receptor modulator for emergency contraception: A randomized controlled trial

Obstetrics and Gynecology

Volumn 108, Issue 5, 2006, Pages 1089-1097

  Creinin, Mitchell D ^a   Schlaff, William ^b   Archer, David F ^b   Wan, Livia ^b   Frezieres, Ron ^b   Thomas, Michael ^b   Rosenberg, Michael ^b   Higgins, James ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

17ALPHA ACETOXY 11BETA (4 DIMETHYLAMINOPHENYL) 19 NORPREGNA 4,9 DIENE 3,20 DIONE; CHORIONIC GONADOTROPIN BETA SUBUNIT; LEVONORGESTREL; PROGESTERONE RECEPTOR;

ADULT; ARTICLE; BLEEDING; BREAST TENDERNESS; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EMERGENCY CONTRACEPTION; FATIGUE; FEMALE; FOLLOW UP; HEADACHE; HUMAN; LOWER ABDOMINAL PAIN; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; NAUSEA; PREGNANT WOMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEXUAL BEHAVIOR; SEXUAL INTERCOURSE; SPOTTING; UNSPECIFIED SIDE EFFECT; URINALYSIS; VOMITING;

ADOLESCENT; ADULT; CONTRACEPTIVES, POSTCOITAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LEVONORGESTREL; NORPREGNADIENES; PREGNANCY; PREGNANCY RATE;

EID: 33750512155     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000239440.02284.45     Document Type: Article

References (23)

1. Cheng L, Gulmezoglu AM, Oel CJ, Piaggio G, Ezcurra E, Look PF. Interventions for emergency contraception. Cochrane Database Syst Rev 2004;(3):CD001324.
2. The Kaiser Family Foundation. Women's health care providers' experiences with emergency contraception. Available at: http://www.kff.org/womenshealth/ 3343-index.cfm. Retrieved June 23, 2003.
3. Trussell J, Stewart F, Guest F, Hatcher RA. Emergency contraceptive pills: a simple proposal to reduce unintended pregnancies. Fam Plann Perspect 1992;24:269-73.
4. Haspels AA. Emergency contraception: a review. Contraception 1994;50:101-8.
5. Trussell J, Ellertson C, Stewart F, Raymond EG, Shochet T. The role of emergency contraception. Am J Obstet Gynecol 2004;190:S30-8.
6. Arowojolu AO, Okewole IA, Adekunle AO. Comparative evaluation of the effectiveness and safety of two regimens of levonorgestrel for emergency contraception in Nigerians [published erratum appears in Contraception. 2003;67:165]. Contraception 2002;66:269-73.
7. von Hertzen H, Piaggio G, Ding J, Chen J, Song S, Bartfai G, et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial Lancet 2002;360:1803-10.
8. Xiao BL, Von Hertzen H, Zhao H, Piaggio G. A randomized double-blind comparison of two single doses of mifepristone for emergency contraception. Hum Reprod 2002;17:3084-9.
9. Comparison of three single doses of mifepristone as emergency contraception: a randomized trial. Task Force on Postovulatory Methods of Fertility Regulation. Lancet 1999;353:697-702.
10. Attardi BJ, Burgenson J, Hild SA, Reel JR, Blye RP. CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914. Molec Cell Endocrinol 2002;188:111-23.
11. Reel JR, Hild-Petito S, Blye RP. Antiovulatory and postcoital antifertility activity of the antiprogestin CDB-2914 when administered as single, multiple, or continuous doses to rats. Contraception 1998;58:129-36.
12. Blackwelder W. "Proving the null hypothesis" in clinical trials. Controlled Clin Trials 1982;3:345-53.
13. Wilcox AJ, Weinberg CR, Baird DD. Timing of sexual intercourse in relation to ovulation: effects on the probability of conception, survival of the pregnancy, and sex of the baby. N Engl J Med 1995;333:1517-21.
14. Wilcox AJ, Weinberg CR, Baird DD. Post-ovulatory ageing of the human oocyte and embryo failure. Hum Reprod 1998;13:394-7.
15. Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Task Force on Postovulatory Methods of Fertility Regulation. Lancet 1998;352:428-33.
16. Ho PC, Kwan MS. A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception. Hum Reprod 1993;8:389-92.
17. Wilcox AJ, Dunson DB, Weinberg CR, Trussell J, Baird DD. Likelihood of conception with a single act of intercourse: providing benchmark rates for assessment of post-coital contraceptives. Contraception 2001;63:211-5.
18. Dixon GW, Schlesselman JJ, Ory HW, Blye RP. Ethinyl estradiol and conjugated estrogens as postcoital contraceptives. JAMA 1980;244:1336-9.
19. Trussell J, Rodriguez G, Ellertson C. New estimates of the effectiveness of the Yuzpe regimen of emergency contraception. Contraception 1998;57:363-9.
20. Mikolajczyk RT, Stanford JB. A new method for estimating the effectiveness of emergency contraception that accounts for variation in timing of ovulation and previous cycle length. Fertil Steril 2005;83:1764-70.
21. Creinin MD, Keverline S, Meyn LA. How regular is regular? An analysis of menstrual cycle regularity. Contraception 2004;70:289-92.
22. Stratton P, Hartog B, Hajizadeh N, Piquion J, Sutherland D, Merino M, et al A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women. Hum Reprod 2000;15:1092-9.
23. Blithe DL, Nieman LK, Blye RP, Stratton P, Passaro M. Development of the selective progesterone receptor modulator CDB-2914 for clinical indications. Steroids 2003;68:1013-7.