Steroids and statins: An old and a new anti-inflammatory strategy compared

Perfusion

Volumn 26, Issue 1, 2011, Pages 31-37

  Vukovic, Petar M ^a   Maravic Stojkovic, Vera R ^a   Peric, Miodrag S ^a   Jovic, Miomir Dj ^a   Cirkovic, Milan V ^a   Gradinac, Sinisa Dj ^a   Djukanovic, Bosko P ^a   Milojevic, Predrag S ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

cardiopulmonary bypass; drugs; inflammation; statins

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; INOTROPIC AGENT; INTERLEUKIN 6; METHYLPREDNISOLONE; TROPONIN I;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; CORONARY ARTERY SURGERY; DRUG EFFECT; ENDOTRACHEAL INTUBATION; HEART ATRIUM FIBRILLATION; HEART INDEX; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE REVASCULARIZATION; HEART RATE; HEMODYNAMICS; HOSPITALIZATION; HUMAN; INFECTION; INTENSIVE CARE UNIT; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; MORTALITY; PREOPERATIVE CARE; PRIORITY JOURNAL; PULMONARY ARTERY OCCLUSION PRESSURE; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SYSTEMIC VASCULAR RESISTANCE;

ANTI-INFLAMMATORY AGENTS; FEMALE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PYRROLES; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 78650641188     PISSN: 02676591     EISSN: None     Source Type: Journal    
DOI: 10.1177/0267659110385607     Document Type: Article

References (17)

1. Paparella D., Yau TM, Young E. Cardiopulmonary bypass induced inflammation: pathophysiology and treatement. An update. Eur J Cardiothorac Surg 2002 ; 21: 232-244.
2. Cremer J., Martin M., Redl H., et al. Systemic inflammatory response syndrome after cardiac operations, Ann Thorac Surg 1996 ; 61: 1714-1720.
3. Hennein HA, Ebba H., Rodriguez JL, et al. Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization. J Thorac Cardiovasc Sug 1994 ; 108: 626-635.
4. Asimakopoulos G., Gourlay T. A review of anti-inflammatory strategies in cardiac surgery. Perfusion 2003 ; 18: 7-12.
5. Celik J., Gormus N., Okesli S., Gormus ZI, Solak H. Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-α IL-6, IL-8, IL-10. Perfusion 2004 ; 19: 185-191.
6. Bourbon A., Vionnet M., Leprince P., et al. The effect of methylprednisolone treatement on the cardiopulmonary bypass-induced systemic inflammatory response. Eu J Cardiothorac Surg 2004 ; 26: 932-938.
7. Liakopoulos O., Schmitto J., Kamaier S., et al. Cardiopulmonary and systemic effects of methylprednisolone in patients undergoing cardiac surgery, Ann Thorac Surg 2007 ; 84: 110-119.
8. Chello M., Anselmi A., Spadaccio C., et al. Simvastatin increases neutrophil apoptosis and reduces inflammatory reaction after coronary surgery. Ann Thorac Surg 2007 ; 83: 1374-1380.
9. Chello M., Patti G., Candura D., et al. Effects of atorvastatin on systemic inflammatory response after coronary surgery. Crit Care Med 2006 ; 34: 660-667.
10. Martinez-Commendador JM, Alvarez JR, Mosquera I., et al. Preoperative statin treatment reduces systemic inflammatory response and myocardial damage in cardiac surgery. Eur J Cardiothorac Surg 2009 ; 36: 998-1005.
11. Steer JH, Kroeger KM, Abraham LJ, Joyce DA Glucocorticoids suppress tumor necrosis factor-alpha expression by human monocytic THP-1 cells by suppressing transactivation through adjacent NF-kappaB and c-Jun-activating transcription factor-2 binding sites in the promoter. J Biol Chem 2000 ; 275 (24). 18432-18440.
12. Yared JP, Starr NJ, Torres FK, et al. Effects of single dose, postinduction dexamethasone on recovery after cardiac surgery. Ann Thorac Surg 2000 ; 69: 1420-1424.
13. Chaney MA, Durazo-Arvizu RA, Nikolov MP, Blakeman BP, Bakhos M. Methylprednisolone does not benefit patients undergoing coronary artery bypass grafting and early tracheal extubation. J Thorac Cardiovasc Surg 2001 ; 121 (3). 561-569.
14. Lazar HL, Bao Y., Zhang Y., Bernard SA Pretreatment with statins enhances myocardial protection during coronary revascularization. J Thorac Cardiovasc Surg 2003 ; 125: 1037-1042.
15. Whyte MKB, Meagher LC, MacDermot J., Haslett C. Impairment of function in aging neutrophils is associated with apoptosis. J Immunol 1993 ; 150: 55123-55134.
16. Patti G., Chello M., Candura D., et al. Randomized trial of atorvastatin for reduction of postoperative atrial fibrillation in patients undergoing cardiac surgery: results of ARMYDA-3 (atorvastatin for reduction of dysrhythnia after cardiac surgery). Circulation 2006 ; 114: 1455-1461.
17. Ishida K., Kimura F., Imamaki M., et al. Relation of inflammatory cytokines to atrial fibrillation after off pump coronary artery bypass grafting. Eur J Cardiothorac Surg 2006 ; 29: 501-505.