-
1
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575-581.
-
(1983)
Nature
, vol.302
, pp. 575-581
-
-
Tonegawa, S.1
-
2
-
-
0041646843
-
Joining of immunoglobulin heavy chain gene segments: Implications from a chromosome with evidence of three D-JH fusions
-
Alt, F. W., and D. Baltimore. 1982. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc. Natl. Acad. Sci. USA 79:4118-4122.
-
(1982)
Proc. Natl. Acad. Sci. USA
, vol.79
, pp. 4118-4122
-
-
Alt, F.W.1
Baltimore, D.2
-
3
-
-
0029807339
-
Conditional gene targeting
-
Rajewsky, K., H. Gu, R. Kühn, U. A. Betz, W. Müller, J. Roes, and F. Schwenk. 1996. Conditional gene targeting. J. Clin. Invest. 98:600-603.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 600-603
-
-
Rajewsky, K.1
Gu, H.2
Kühn, R.3
Betz, U.A.4
Müller, W.5
Roes, J.6
Schwenk, F.7
-
4
-
-
85015077644
-
The digital code of DNA
-
Hood, L., and D. Galas. 2003. The digital code of DNA. Nature 421:444-448.
-
(2003)
Nature
, vol.421
, pp. 444-448
-
-
Hood, L.1
Galas, D.2
-
5
-
-
0037461765
-
The double helix and immunology
-
Nossal, G. J. V. 2003. The double helix and immunology. Nature 421:440-444.
-
(2003)
Nature
, vol.421
, pp. 440-444
-
-
Nossal, G.J.V.1
-
6
-
-
0004032583
-
-
U. S. Department of Health and Human Services, Bethesda, MD
-
Kabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of Proteins of Immunological Interest. U. S. Department of Health and Human Services, Bethesda, MD.
-
(1991)
Sequences of Proteins of Immunological Interest
-
-
Kabat, E.A.1
Wu, T.T.2
Perry, H.M.3
Gottesman, K.S.4
Foeller, C.5
-
7
-
-
0028289241
-
Anatomy of the antibody molecule
-
Padlan, E. A. 1994. Anatomy of the antibody molecule. Mol. Immunol. 31:169-217.
-
(1994)
Mol. Immunol.
, vol.31
, pp. 169-217
-
-
Padlan, E.A.1
-
8
-
-
0033711628
-
Diversity in the CDR3 region of V (H) is sufficient for most antibody specificities
-
Xu, J. L., and M. M. Davis. 2000. Diversity in the CDR3 region of V (H) is sufficient for most antibody specificities. Immunity 13:37-45.
-
(2000)
Immunity
, vol.13
, pp. 37-45
-
-
Xu, J.L.1
Davis, M.M.2
-
9
-
-
0021216208
-
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
-
Desiderio, S. V., G. D. Yancopoulos, M. Paskind, E. Thomas, M. A. Boss, N. R. Landau, F. W. Alt, and D. Baltimore. 1984. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature 311:752-755.
-
(1984)
Nature
, vol.311
, pp. 752-755
-
-
Desiderio, S.V.1
Yancopoulos, G.D.2
Paskind, M.3
Thomas, E.4
Boss, M.A.5
Landau, N.R.6
Alt, F.W.7
Baltimore, D.8
-
10
-
-
0027369562
-
Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
-
Komori, T., A. Okada, V. Stewart, and F. W. Alt. 1993. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 261:1171-1175.
-
(1993)
Science
, vol.261
, pp. 1171-1175
-
-
Komori, T.1
Okada, A.2
Stewart, V.3
Alt, F.W.4
-
11
-
-
0027452074
-
Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
-
Gilfillan, S., A. Dierich, M. Lemeur, C. Benoist, and D. Mathis. 1993. Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 261:1175-1178.
-
(1993)
Science
, vol.261
, pp. 1175-1178
-
-
Gilfillan, S.1
Dierich, A.2
Lemeur, M.3
Benoist, C.4
Mathis, D.5
-
12
-
-
20444394778
-
Development of the expressed Ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge that are first established in early B cell progenitors
-
Ivanov, I. I., R. L. Schelonka, Y. Zhuang, G. L. Gartland, M. Zemlin, and H. W. Schroeder, Jr. 2005. Development of the expressed Ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge that are first established in early B cell progenitors. J. Immunol. 174:7773-7780.
-
(2005)
J. Immunol.
, vol.174
, pp. 7773-7780
-
-
Ivanov, I.I.1
Schelonka, R.L.2
Zhuang, Y.3
Gartland, G.L.4
Zemlin, M.5
Schroeder Jr., H.W.6
-
13
-
-
0025335392
-
Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: Implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation
-
Gu, H., I. Förster, and K. Rajewsky. 1990. Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. EMBO J. 9:2133-2140.
-
(1990)
EMBO J.
, vol.9
, pp. 2133-2140
-
-
Gu, H.1
Förster, I.2
Rajewsky, K.3
-
14
-
-
0026321708
-
Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells
-
Feeney, A. J. 1991. Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells. J. Immunol. 147:4343-4350.
-
(1991)
J. Immunol.
, vol.147
, pp. 4343-4350
-
-
Feeney, A.J.1
-
15
-
-
77957571907
-
D (H) and J (H) usage in murine fetal liver mirrors that of human fetal liver
-
Schelonka, R. L., E. Szymanska, A. M. Vale, Y. Zhuang, G. L. Gartland, and H. W. Schroeder, Jr. 2010. D (H) and J (H) usage in murine fetal liver mirrors that of human fetal liver. Immunogenetics 62:653-666.
-
(2010)
Immunogenetics
, vol.62
, pp. 653-666
-
-
Schelonka, R.L.1
Szymanska, E.2
Vale, A.M.3
Zhuang, Y.4
Gartland, G.L.5
Schroeder Jr., H.W.6
-
16
-
-
0001898834
-
Ontogeny of the immune response: A perspective
-
M. D. Cooper, ed. Raven Press, New York
-
Silverstein, A. M. 1977. Ontogeny of the immune response: a perspective. In Development of Host Defense. M. D. Cooper, ed. Raven Press, New York, p. 1-10.
-
(1977)
Development of Host Defense
, pp. 1-10
-
-
Silverstein, A.M.1
-
17
-
-
27744561374
-
A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function
-
Schelonka, R. L., I. I. Ivanov, D. Jung, G. C. Ippolito, L. Nitschke, Y. Zhuang, G. L. Gartland, J. Pelkonen, F. W. Alt, K. Rajewsky, and H. W. Schroeder, Jr. 2005. A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. J. Immunol. 175:6624-6632.
-
(2005)
J. Immunol.
, vol.175
, pp. 6624-6632
-
-
Schelonka, R.L.1
Ivanov, I.I.2
Jung, D.3
Ippolito, G.C.4
Nitschke, L.5
Zhuang, Y.6
Gartland, G.L.7
Pelkonen, J.8
Alt, F.W.9
Rajewsky, K.10
Schroeder Jr., H.W.11
-
18
-
-
33745053586
-
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
-
Ippolito, G. C., R. L. Schelonka, M. Zemlin, I. I. Ivanov, R. Kobayashi, C. Zemlin, G. L. Gartland, L. Nitschke, J. Pelkonen, K. Fujihashi, et al. 2006. Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. J. Exp. Med. 203:1567-1578.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1567-1578
-
-
Ippolito, G.C.1
Schelonka, R.L.2
Zemlin, M.3
Ivanov, I.I.4
Kobayashi, R.5
Zemlin, C.6
Gartland, G.L.7
Nitschke, L.8
Pelkonen, J.9
Fujihashi, K.10
-
19
-
-
0033058759
-
H3-rules: Identification of CDR-H3 structures in antibodies
-
Shirai, H., A. Kidera, and H. Nakamura. 1999. H3-rules: identification of CDR-H3 structures in antibodies. FEBS Lett. 455:188-197.
-
(1999)
FEBS Lett.
, vol.455
, pp. 188-197
-
-
Shirai, H.1
Kidera, A.2
Nakamura, H.3
-
20
-
-
0030577371
-
Structural classification of CDR-H3 in antibodies
-
Shirai, H., A. Kidera, and H. Nakamura. 1996. Structural classification of CDR-H3 in antibodies. FEBS Lett. 399:1-8.
-
(1996)
FEBS Lett.
, vol.399
, pp. 1-8
-
-
Shirai, H.1
Kidera, A.2
Nakamura, H.3
-
21
-
-
34248209055
-
Categorical selection of the antibody repertoire in splenic B cells
-
Schelonka, R. L., J. Tanner, Y. Zhuang, G. L. Gartland, M. Zemlin, and H. W. Schroeder, Jr. 2007. Categorical selection of the antibody repertoire in splenic B cells. Eur. J. Immunol. 37:1010-1021.
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 1010-1021
-
-
Schelonka, R.L.1
Tanner, J.2
Zhuang, Y.3
Gartland, G.L.4
Zemlin, M.5
Schroeder Jr., H.W.6
-
23
-
-
58849143882
-
Regulation of repertoire development through genetic control of DH reading frame preference
-
Zemlin, M., R. L. Schelonka, G. C. Ippolito, C. Zemlin, Y. Zhuang, G. L. Gartland, L. Nitschke, J. Pelkonen, K. Rajewsky, and H. W. Schroeder, Jr. 2008. Regulation of repertoire development through genetic control of DH reading frame preference. J. Immunol. 181:8416-8424.
-
(2008)
J. Immunol.
, vol.181
, pp. 8416-8424
-
-
Zemlin, M.1
Schelonka, R.L.2
Ippolito, G.C.3
Zemlin, C.4
Zhuang, Y.5
Gartland, G.L.6
Nitschke, L.7
Pelkonen, J.8
Rajewsky, K.9
Schroeder Jr., H.W.10
-
24
-
-
0021285559
-
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines
-
Yancopoulos, G. D., S. V. Desiderio, M. Paskind, J. F. Kearney, D. Baltimore, and F. W. Alt. 1984. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 311:727-733.
-
(1984)
Nature
, vol.311
, pp. 727-733
-
-
Yancopoulos, G.D.1
Desiderio, S.V.2
Paskind, M.3
Kearney, J.F.4
Baltimore, D.5
Alt, F.W.6
-
25
-
-
0027263407
-
V-region directed selection in differentiating B lymphocytes
-
Huetz, F., L. Carlsson, U. C. Tornberg, and D. Holmberg. 1993. V-region directed selection in differentiating B lymphocytes. EMBO J. 12:1819-1826.
-
(1993)
EMBO J.
, vol.12
, pp. 1819-1826
-
-
Huetz, F.1
Carlsson, L.2
Tornberg, U.C.3
Holmberg, D.4
-
26
-
-
0029670173
-
Frequency of VH81x usage during B cell development: Initial decline in usage is independent of Ig heavy chain cell surface expression
-
Marshall, A. J., G. E. Wu, and G. J. Paige. 1996. Frequency of VH81x usage during B cell development: initial decline in usage is independent of Ig heavy chain cell surface expression. J. Immunol. 156:2077-2084.
-
(1996)
J. Immunol.
, vol.156
, pp. 2077-2084
-
-
Marshall, A.J.1
Wu, G.E.2
Paige, G.J.3
-
27
-
-
0035384899
-
Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location
-
Williams, G. S., A. Martinez, A. Montalbano, A. Tang, A. Mauhar, K. M. Ogwaro, D. Merz, C. Chevillard, R. Riblet, and A. J. Feeney. 2001. Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location. J. Immunol. 167:257-263.
-
(2001)
J. Immunol.
, vol.167
, pp. 257-263
-
-
Williams, G.S.1
Martinez, A.2
Montalbano, A.3
Tang, A.4
Mauhar, A.5
Ogwaro, K.M.6
Merz, D.7
Chevillard, C.8
Riblet, R.9
Feeney, A.J.10
-
28
-
-
0026610950
-
Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies
-
Feeney, A. J. 1992. Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies. J. Immunol. 149:222-229.
-
(1992)
J. Immunol.
, vol.149
, pp. 222-229
-
-
Feeney, A.J.1
-
29
-
-
0020475449
-
A simple method for displaying the hydropathic character of a protein
-
Kyte, J., and R. F. Doolittle. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132.
-
(1982)
J. Mol. Biol.
, vol.157
, pp. 105-132
-
-
Kyte, J.1
Doolittle, R.F.2
-
30
-
-
0021152462
-
Three-dimensional structure of membrane and surface proteins
-
Eisenberg, D. 1984. Three-dimensional structure of membrane and surface proteins. Annu. Rev. Biochem. 53:595-623.
-
(1984)
Annu. Rev. Biochem.
, vol.53
, pp. 595-623
-
-
Eisenberg, D.1
-
32
-
-
0035886939
-
Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/)-Mice
-
Carvalho, T. L., T. Mota-Santos, A. Cumano, J. Demengeot, and P. Vieira. 2001. Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/)-mice. J. Exp. Med. 194:1141-1150.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 1141-1150
-
-
Carvalho, T.L.1
Mota-Santos, T.2
Cumano, A.3
Demengeot, J.4
Vieira, P.5
-
33
-
-
0032479179
-
Anatomy of hot spots in protein interfaces
-
Bogan, A. A., and K. S. Thorn. 1998. Anatomy of hot spots in protein interfaces. J. Mol. Biol. 280:1-9.
-
(1998)
J. Mol. Biol.
, vol.280
, pp. 1-9
-
-
Bogan, A.A.1
Thorn, K.S.2
-
34
-
-
0041689676
-
Predominant autoantibody production by early human B cell precursors
-
Wardemann, H., S. Yurasov, A. Schaefer, J. W. Young, E. Meffre, and M. C. Nussenzweig. 2003. Predominant autoantibody production by early human B cell precursors. Science 301:1374-1377.
-
(2003)
Science
, vol.301
, pp. 1374-1377
-
-
Wardemann, H.1
Yurasov, S.2
Schaefer, A.3
Young, J.W.4
Meffre, E.5
Nussenzweig, M.C.6
-
35
-
-
34548145529
-
Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire
-
Nguyen, H. H., M. Zemlin, I. I. Ivanov, J. Andrasi, C. Zemlin, H. L. Vu, R. L. Schelonka, H. W. Schroeder, Jr., and J. Mestecky. 2007. Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire. J. Virol. 81:9331-9338.
-
(2007)
J. Virol.
, vol.81
, pp. 9331-9338
-
-
Nguyen, H.H.1
Zemlin, M.2
Ivanov, I.I.3
Andrasi, J.4
Zemlin, C.5
Vu, H.L.6
Schelonka, R.L.7
Schroeder Jr., H.W.8
Mestecky, J.9
-
36
-
-
76249088918
-
Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide alpha-1, 3 dextran
-
Mahmoud, T. I., and J. F. Kearney. 2010. Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide alpha-1, 3 dextran. J. Immunol. 184:851-858.
-
(2010)
J. Immunol.
, vol.184
, pp. 851-858
-
-
Mahmoud, T.I.1
Kearney, J.F.2
-
37
-
-
0035884989
-
Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas (lpr) mice
-
Feeney, A. J., B. R. Lawson, D. H. Kono, and A. N. Theofilopoulos. 2001. Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas (lpr) mice. J. Immunol. 167:3486-3493.
-
(2001)
J. Immunol.
, vol.167
, pp. 3486-3493
-
-
Feeney, A.J.1
Lawson, B.R.2
Kono, D.H.3
Theofilopoulos, A.N.4
-
38
-
-
1642358542
-
Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas (lpr) mice
-
Robey, I. F., M. Peterson, M. S. Horwitz, D. H. Kono, T. Stratmann, A. N. Theofilopoulos, N. Sarvetnick, L. Teyton, and A. J. Feeney. 2004. Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas (lpr) mice. J. Immunol. 172:4624-4629.
-
(2004)
J. Immunol.
, vol.172
, pp. 4624-4629
-
-
Robey, I.F.1
Peterson, M.2
Horwitz, M.S.3
Kono, D.H.4
Stratmann, T.5
Theofilopoulos, A.N.6
Sarvetnick, N.7
Teyton, L.8
Feeney, A.J.9
-
39
-
-
0033984311
-
Effect of a genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production by C57BL6 Fas (lpr) mice
-
Molano, I. D., M. K. Wloch, A. A. Alexander, H. Watanabe, and G. S. Gilkeson. 2000. Effect of a genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production by C57BL6 Fas (lpr) mice. Clin. Immunol. 94:24-32.
-
(2000)
Clin. Immunol.
, vol.94
, pp. 24-32
-
-
Molano, I.D.1
Wloch, M.K.2
Alexander, A.A.3
Watanabe, H.4
Gilkeson, G.S.5
-
40
-
-
0037527668
-
Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice
-
Molano, I. D., S. Redmond, H. Sekine, X. K. Zhang, C. Reilly, F. Hutchison, P. Ruiz, and G. S. Gilkeson. 2003. Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice. Clin. Immunol. 107:186-197.
-
(2003)
Clin. Immunol.
, vol.107
, pp. 186-197
-
-
Molano, I.D.1
Redmond, S.2
Sekine, H.3
Zhang, X.K.4
Reilly, C.5
Hutchison, F.6
Ruiz, P.7
Gilkeson, G.S.8
-
41
-
-
0032534606
-
Terminal deoxynucleotidyl transferase deficiency reduces the incidence of autoimmune nephritis in (New Zealand Black x New Zealand White) F1 mice
-
Conde, C., S. Weller, S. Gilfillan, L. Marcellin, T. Martin, and J. L. Pasquali. 1998. Terminal deoxynucleotidyl transferase deficiency reduces the incidence of autoimmune nephritis in (New Zealand Black x New Zealand White) F1 mice. J. Immunol. 161:7023-7030.
-
(1998)
J. Immunol.
, vol.161
, pp. 7023-7030
-
-
Conde, C.1
Weller, S.2
Gilfillan, S.3
Marcellin, L.4
Martin, T.5
Pasquali, J.L.6
-
42
-
-
0025017688
-
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
-
Shlomchik, M. J., M. A. Mascelli, H. Shan, M. Z. Radic, D. S. Pisetsky, A. Marshak-Rothstein, and M. G. Weigert. 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171:265-292.
-
(1990)
J. Exp. Med.
, vol.171
, pp. 265-292
-
-
Shlomchik, M.J.1
Mascelli, M.A.2
Shan, H.3
Radic, M.Z.4
Pisetsky, D.S.5
Marshak-Rothstein, A.6
Weigert, M.G.7
|