Structural characterization of a high affinity mononuclear site in the copper(II)-α-synuclein complex

Journal of the American Chemical Society

Volumn 132, Issue 51, 2010, Pages 18057-18066

  Bortolus, Marco ^a   Bisaglia, Marco ^a   Zoleo, Alfonso ^a   Fittipaldi, Maria ^b   Benfatto, Maurizio ^c   Bubacco, Luigi ^a   Maniero, Anna Lisa ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c INFN LABORATORI NAZIONALI DI FRASCATI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION PROCESS; AMINO ACID PROTEINS; AMINO TERMINUS; AXIAL LIGAND; BINDING MODES; CONTINUOUS WAVE; COPPER (II); COPPER COMPLEXES; COPPER IONS; CORRELATION SPECTROSCOPY; DIVALENT COPPER; ELECTRON NUCLEAR DOUBLE RESONANCE; ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY; ELECTRON SPIN-ECHO ENVELOPE MODULATIONS; EPR PARAMETERS; HIGH AFFINITY; HIGH AFFINITY BINDING; HYPERFINES; K-EDGE ABSORPTION; LEWY BODIES; MAGNETIC PARAMETERS; METAL-BINDING PROTEIN; MULTI FREQUENCY; OXYGEN LIGANDS; PARKINSON'S DISEASE; SQUARE PLANAR GEOMETRY; STOICHIOMETRIC RATIO; STRUCTURAL CHARACTERIZATION; STRUCTURAL FEATURE; STRUCTURAL MODELS; SYNUCLEIN; WATER MOLECULE;

AGGLOMERATION; AMINO ACIDS; BINDING ENERGY; COPPER; COPPER COMPOUNDS; EXPERIMENTS; GEOMETRY; HEAVY METALS; LIGANDS; METAL IONS; MODEL STRUCTURES; OLIGOMERIZATION; OLIGOMERS; OXYGEN; PARAMAGNETIC RESONANCE; PARAMAGNETISM; PROTEINS; RESONANCE; SPECTROSCOPY; SPIN DYNAMICS;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

ALPHA SYNUCLEIN; COPPER COMPLEX; COPPER ION;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; OLIGOMERIZATION; PH; STRUCTURE ANALYSIS;

ALPHA-SYNUCLEIN; COORDINATION COMPLEXES; COPPER; ELECTRON SPIN RESONANCE SPECTROSCOPY; HISTIDINE; HUMANS; LEWY BODIES; METALLOPROTEINS; PROTEIN BINDING;

EID: 78650606731     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja103338n     Document Type: Article

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