The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate

Brazilian Journal of Medical and Biological Research

Volumn 43, Issue 12, 2010, Pages 1178-1183

  Cechetti, F ^a   Worm, P V ^a   Pereira, L O ^a   Siqueira, I R ^a   Netto, C A ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Chronic cerebral hypoperfusion; Hippocampus; Spatial memory; Striatum; Water maze

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY LIGATION; ARTICLE; BRAIN BLOOD FLOW; COGNITION; COGNITIVE DEFECT; COMMON CAROTID ARTERY; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; ISCHEMIA; LEARNING; MALE; MAZE TEST; MORPHOLOGY; NONHUMAN; OUTCOME ASSESSMENT; PERFORMANCE; RAT; SPATIAL MEMORY; STANDARD; SURVIVAL RATE;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 78650593063     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2010007500124     Document Type: Article

References (40)

1. de la Torre JC. Impaired brain microcirculation may trigger Alzheimer's disease. Neurosci Biobehav Rev 1994; 18: 397-401.
2. Kalaria RN. The role of cerebral ischemia in Alzheimer's disease. Neurobiol Aging 2000; 21: 321-330.
3. Sopala M, Danysz W. Chronic cerebral hypoperfusion in the rat enhances age-related deficits in spatial memory. J Neural Transm 2001; 108: 1445-1456.
4. Ohta H, Nishikawa H, Kimura H, Anayama H, Miyamoto M. Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats. Neuroscience 1997; 79: 1039-1050.
5. Komatani A, Yamaguchi K, Sugai Y, Takanashi T, Kera M, Shinohara M, et al. Assessment of demented patients by dynamic SPECT of inhaled xenon-133. J Nucl Med 1988; 29: 1621-1626.
6. Farkas E, Luiten PG, Bari F. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev 2007; 54: 162-180.
7. Pulsinelli WA, Brierley JB, Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 1982; 11: 491-498.
8. Smith ML, Auer RN, Siesjo BK. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol 1984; 64: 319-332.
9. Freund TF, Buzsaki G, Leon A, Baimbridge KG, Somogyi P. Relationship of neuronal vulnerability and calcium binding protein immunoreactivity in ischemia. Exp Brain Res 1990; 83: 55-66.
10. Otori T, Katsumata T, Muramatsu H, Kashiwagi F, Katayama Y, Terashi A. Long-term measurement of cerebral blood flow and metabolism in a rat chronic hypoperfusion model. Clin Exp Pharmacol Physiol 2003; 30: 266-272.
11. Tsuchiya M, Sako K, Yura S, Yonemasu Y. Cerebral blood flow and histopathological changes following permanent bilateral carotid artery ligation in Wistar rats. Exp Brain Res 1992; 89: 87-92.
12. Ulrich PT, Kroppenstedt S, Heimann A, Kempski O. Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats. Stroke 1998; 29: 2412-2420.
13. Sarti C, Pantoni L, Bartolini L, Inzitari D. Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models. J Neurol Sci 2002; 203-204: 263-266.
14. Sarti C, Pantoni L, Bartolini L, Inzitari D. Persistent impair- ment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat. Behav Brain Res 2002; 136: 13-20.
15. Pereira LO, Nabinger PM, Strapasson AC, Nardin P, Goncalves CA, Siqueira IR, et al. Long-term effects of environmental stimulation following hypoxia-ischemia on the oxidative state and BDNF levels in rat hippocampus and frontal cortex. Brain Res 2009; 1247: 188-195.
16. Valentim LM, Michalowski CB, Gottardo SP, Pedroso L, Gestrich LG, Netto CA, et al. Effects of transient cerebral ischemia on glial fibrillary acidic protein phosphorylation and immunocontent in rat hippocampus. Neuroscience 1999; 91: 1291-1297.
17. Farkas E, Timmer NM, Domoki F, Mihaly A, Luiten PG, Bari F. Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. Neurosci Lett 2005; 387: 168-172.
18. Farkas E, Institoris A, Domoki F, Mihaly A, Bari F. The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat. Brain Res 2006; 1087: 168-174.
19. Institoris A, Farkas E, Berczi S, Sule Z, Bari F. Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats. Eur J Pharmacol 2007; 574: 29-38.
20. Netto CA, Hodges H, Sinden JD, Le Peillet E, Kershaw T, Sowinski P, et al. Effects of fetal hippocampal field grafts on ischaemic-induced deficits in spatial navigation in the water maze. Neuroscience 1993; 54: 69-92.
21. Pereira LO, Strapasson AC, Nabinger PM, Achaval M, Netto CA. Early enriched housing results in partial recovery of memory deficits in female, but not in male, rats after neonatal hypoxia-ischemia. Brain Res 2008; 1218: 257-266.
22. Rodrigues AL, Arteni NS, Abel C, Zylbersztejn D, Chazan R, Viola G, et al. Tactile stimulation and maternal separation prevent hippocampal damage in rats submitted to neonatal hypoxia-ischemia. Brain Res 2004; 1002: 94-99.
23. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 2nd edn. Sydney: Academic Press; 1986.
24. Zhao Q, Murakami Y, Tohda M, Watanabe H, Matsumoto K. Preventive effect of chotosan, a Kampo medicine, on transient ischemia-induced learning deficit is mediated by stimulation of muscarinic M1 but not nicotinic receptor. Biol Pharm Bull 2005; 28: 1873-1878.
25. Ni J, Ohta H, Matsumoto K, Watanabe H. Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats. Brain Res 1994; 653: 231-236.
26. Pappas BA, de la Torre JC, Davidson CM, Keyes MT, Fortin T. Chronic reduction of cerebral blood flow in the adult rat: late-emerging CA1 cell loss and memory dysfunction. Brain Res 1996; 708: 50-58.
27. De Jong GI, Farkas E, Stienstra CM, Plass JR, Keijser JN, de la Torre JC, et al. Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment. Neuroscience 1999; 91: 203-210.
28. Nunn J, Hodges H. Cognitive deficits induced by global cerebral ischaemia: relationship to brain damage and reversal by transplants. Behav Brain Res 1994; 65: 1-31.
29. Xiong Z, Liu C, Wang F, Li C, Wang W, Wang J, et al. Protective effects of breviscapine on ischemic vascular dementia in rats. Biol Pharm Bull 2006; 29: 1880-1885.
30. Jaspers RM, Block F, Heim C, Sontag KH. Spatial learning is affected by transient occlusion of common carotid arteries (2VO): comparison of behavioural and histopathological changes after '2VO' and 'four-vessel-occlusion' in rats. Neurosci Lett 1990; 117: 149-153.
31. Lyeth BG, Jenkins LW, Hamm RJ, Dixon CE, Phillips LL, Clifton GL, et al. Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain Res 1990; 526: 249-258.
32. Olsen GM, Scheel-Kruger J, Moller A, Jensen LH. Does neuronal damage of CA1 relate to spatial memory performance of rats subjected to transient forebrain ischemia? Acta Neurol Scand 1994; 89: 204-209.
33. Murakami Y, Zhao Q, Harada K, Tohda M, Watanabe H, Matsumoto K. Choto-san, a Kampo formula, improves chronic cerebral hypoperfusion-induced spatial learning deficit via stimulation of muscarinic M1 receptor. Pharmacol Biochem Behav 2005; 81: 616-625.
34. Brandeis R, Brandys Y, Yehuda S. The use of the Morris Water Maze in the study of memory and learning. Int J Neurosci 1989; 48: 29-69.
35. McNamara RK, Skelton RW. The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res Brain Res Rev 1993; 18: 33-49.
36. Kalaria RN, Harik SI. Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease. J Neurochem 1989; 53: 1083-1088.
37. Simpson IA, Chundu KR, Davies-Hill T, Honer WG, Davies P. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann Neurol 1994; 35: 546-551.
38. Henneberry RC, Novelli A, Cox JA, Lysko PG. Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons. An hypothesis for cell death in aging and disease. Ann N Y Acad Sci 1989; 568: 225-233.
39. Vicente E, Degerone D, Bohn L, Scornavaca F, Pimentel A, Leite MC, et al. Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat. Brain Res 2009; 1251: 204-212.
40. Kaliszewski C, Fernandez LA, Wicke JD. Differences in mortality rate between abrupt and progressive carotid ligation in the gerbil: role of endogenous angiotensin II. J Cereb Blood Flow Metab 1988; 8: 149-154.