BCL2L10 protein regulates apoptosis/proliferation through differential pathways in gastric cancer cells

Journal of Pathology

Volumn 223, Issue 3, 2011, Pages 400-409

  Xu, Jing Da ^a   Cao, Xi Xi ^a   Long, Zi Wen ^b   Liu, Xiu Ping ^a   Furuya, Tomoko ^c   Xu, Jia Wen ^a   Liu, Xiao Li ^a   Xu, Zu De ^a   Sasaki, Kohsuke ^c   Li, Qing Quan ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; BCL2L10; Cancer; Hypermethylation; Proliferation; Stomach

Indexed keywords

BCL2L10 PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; IMMUNOBLOTTING; IN VITRO STUDY; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 78650591943     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2811     Document Type: Article

References (41)

1. Parkin DM, Bray F, Ferlay J, et al., Global cancer statistics, 2002. CA Cancer J. Clin 2005; 55: 74-108. (Pubitemid 40372904)
2. Xu JD, Furuya T, Cao XX, et al., Loss of BCL2L10 protein expression as prognostic predictor for poor clinical outcome in gastric carcinoma. Histopathology 2010; (in press); DOI: HISTOP-11-09-0662.
3. Mikata R, Yokosuka O, Fukai K, et al., Analysis of genes upregulated by the demethylating agent 5-aza-2′ - deoxycytidine in gastric cancer cell lines. Int J Cancer 2006; 119: 1616-1622. (Pubitemid 44258767)
4. Inohara N, Gourley TS, Carrio R, et al., Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. J Biol Chem 1998; 273: 32479-32486. (Pubitemid 28557622)
5. Luciano F, Krajewska M, Ortiz-Rubio P, et al., Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood 2007; 109: 3849-3855. (Pubitemid 46641736)
6. Kang Y, Lee DC, Han J, et al., NM23-H2 involved in negative regulation of Diva and Bcl2L10 in apoptosis signaling. Biochem Biophys Res Commun 2007; 359: 76-82. (Pubitemid 46836672)
7. Kim JH, Yoon S, Won M, et al., HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. Cell Physiol Biochem 2009; 23: 43-52.
8. Song Q, Kuang Y, Dixit VM, et al., Boo, a novel negative regulator of cell death, interacts with Apaf-1. EMBO J 1999; 18: 167-178. (Pubitemid 29005033)
9. Ke N, Godzik A, Reed JC,. Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. J Biol Chem 2001; 276: 12481-12484. (Pubitemid 37385152)
10. Naumann U, Weit S, Wischhusen J, et al., Diva/Boo is a negative regulator of cell death in human glioma cells. FEBS Lett 2001; 505: 23-26. (Pubitemid 32831023)
11. Zhang H, Holzgreve W, De Geyter C,. Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway. Hum Mol Genet 2001; 10: 2329-2339. (Pubitemid 33069539)
12. Zhai D, Ke N, Zhang H, et al., Characterization of the anti-apoptotic mechanism of Bcl-B. Biochem J 2003; 376: 229-236. (Pubitemid 37487218)
13. Beverly LJ, Varmus HE,. MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene 2009; 28: 1274-1279.
14. Guillemin Y, Lalle P, Gillet G, et al., Oocytes and early embryos selectively express the survival factor BCL2L10. J Mol Med 2009; 87: 923-940.
15. Adams JM, Cory S,. The Bcl-2 protein family: arbiters of cell survival. Science 1998; 281: 1322-1326. (Pubitemid 28406819)
16. Gross A, McDonnell JM, Korsmeyer SJ,. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13: 1899-1911. (Pubitemid 29407357)
17. Cory S, Adams JM,. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002; 2: 647-656. (Pubitemid 37328916)
18. Cory S, Huang DC, Adams JM,. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22: 8590-8607. (Pubitemid 38028528)
19. Krajewska M, Kitada S, Winter JN, et al., Bcl-B expression in human epithelial and nonepithelial malignancies. Clin Cancer Res 2008; 14: 3011-3021.
20. Sato F, Meltzer SJ,. CpG island hypermethylation in progression of esophageal and gastric cancer. Cancer 2006; 106: 483-493. (Pubitemid 43157610)
21. Hamilton JP, Meltzer SJ,. A review of the genomics of gastric cancer. Clin Gastroenterol Hepatol 2006; 4: 416-425.
22. Leung WK, Yu J, To KF, et al., Apoptosis and proliferation in Helicobacter pylori-associated gastric intestinal metaplasia. Aliment Pharmacol Ther 2001; 15: 1467-1472. (Pubitemid 32835556)
23. Wambura C, Aoyama N, Shirasaka D, et al., Effect of Helicobacter pylori-induced cyclooxygenase-2 on gastric epithelial cell kinetics: implication for gastric carcinogenesis. Helicobacter 2002; 7: 129-138. (Pubitemid 34507080)
24. Wambura C, Aoyama N, Shirasaka D, et al., Cell kinetic balance in gastric mucosa with intestinal metaplasia after Helicobacter pylori eradication: 2-year follow-up study. Dig Liver Dis 2004; 36: 178-186. (Pubitemid 41130635)
25. Tang C, Liu C, Zhou X, et al., Enhanced inhibitive effects of combination of rofecoxib and octreotide on the growth of human gastric cancer. Int J Cancer 2004; 112: 470-474. (Pubitemid 39390613)
26. Liu X, Kim CN, Yang J, et al., Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996; 86: 147-157. (Pubitemid 26256586)
27. Luo JL, Kamata H, Karin M,. IKK/NF-κB signaling: balancing life and death - a new approach to cancer therapy. J Clin Invest 2005; 115: 2625-2632. (Pubitemid 41434385)
28. Micheau O, Tschopp J,. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003; 114: 181-190. (Pubitemid 36936912)
29. Han Z, Wu K, Shen H, et al., Akt1/protein kinase Bα is involved in gastric cancer progression and cell proliferation. Dig Dis Sci 2008; 53: 1801-1810. (Pubitemid 351748978)
30. Chang F, Lee JT, Navolanic PM, et al., Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 2003; 17: 590-603. (Pubitemid 36395654)
31. Liang J, Slingerland JM,. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003; 2: 339-345.
32. Drudi Metalli V, Mancino MG, Mancino A, et al., Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system. Dig Liver Dis 2007; 39: 654-662. (Pubitemid 46900088)
33. Davis RJ,. Signal transduction by the JNK group of MAP kinases. Cell 2000; 103: 239-252.
34. Coen L, Le Blay K, Rowe I, et al., Caspase-9 regulates apoptosis/proliferation balance during metamorphic brain remodeling in Xenopus. Proc Natl Acad Sci USA 2007; 104: 8502-8507. (Pubitemid 47175517)
35. Li RJ, Qiu SD, Wang HX, et al., Androgen receptor: a new player associated with apoptosis and proliferation of pancreatic β-cell in type 1 diabetes mellitus. Apoptosis 2008; 13: 959-971.
36. McMurtry MS, Bonnet S, Wu X, et al., Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 2004; 95: 830-840. (Pubitemid 39390586)
37. Efrati S, Berman S, Goldfinger N, et al., Enhanced angiotensin II production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertension. J Hypertens 2007; 25: 1041-1052. (Pubitemid 46573124)
38. Arici M, Chana R, Lewington A, et al., Stimulation of proximal tubular cell apoptosis by albumin-bound fatty acids mediated by peroxisome proliferator activated receptor-γ. J Am Soc Nephrol 2003; 14: 17-27. (Pubitemid 36026293)
39. Parker JE, Mufti GJ, Rasool F, et al., The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood 2000; 96: 3932-3938.
40. Schmitz KJ, Lang H, Wohlschlaeger J, et al., Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma. Virchows Arch 2007; 450: 135-141. (Pubitemid 46295237)
41. Sinicrope FA, Rego RL, Garrity-Park MM, et al., Alterations in cell proliferation and apoptosis in colon cancers with microsatellite instability. Int J Cancer 2007; 120: 1232-1238. (Pubitemid 46256775)