메뉴 건너뛰기




Volumn 107, Issue 48, 2010, Pages 20602-20609

Imbalance of ionic conductances contributes to diverse symptoms of demyelination

Author keywords

Axon; Hodgkin Huxley model; Leak conductance; Morris Lecar model; Multiple sclerosis

Indexed keywords

POTASSIUM CHANNEL;

EID: 78650580180     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013798107     Document Type: Article
Times cited : (39)

References (48)
  • 1
    • 0020043188 scopus 로고
    • Can neuralgias arise from minor demyelination? Spontaneous firing, mechanosensitivity, and afterdischarge from conducting axons
    • Calvin WH, Devor M, Howe JF (1982) Can neuralgias arise from minor demyelination? Spontaneous firing, mechanosensitivity, and afterdischarge from conducting axons. Exp Neurol 75:755-763.
    • (1982) Exp Neurol , vol.75 , pp. 755-763
    • Calvin, W.H.1    Devor, M.2    Howe, J.F.3
  • 2
    • 0030987951 scopus 로고    scopus 로고
    • Slow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons
    • Kapoor R, Li YG, Smith KJ (1997) Slow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons. Brain 120:647-652.
    • (1997) Brain , vol.120 , pp. 647-652
    • Kapoor, R.1    Li, Y.G.2    Smith, K.J.3
  • 3
    • 0035207990 scopus 로고    scopus 로고
    • Trigeminal neuralgia: Pathology and pathogenesis
    • Love S, Coakham HB (2001) Trigeminal neuralgia: Pathology and pathogenesis. Brain 124:2347-2360.
    • (2001) Brain , vol.124 , pp. 2347-2360
    • Love, S.1    Coakham, H.B.2
  • 4
    • 58149357046 scopus 로고    scopus 로고
    • Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: Thalamic hyperexcitability after spinothalamic tract lesions
    • Wang G, Thompson SM (2008) Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: Thalamic hyperexcitability after spinothalamic tract lesions. J Neurosci 28:11959-11969.
    • (2008) J Neurosci , vol.28 , pp. 11959-11969
    • Wang, G.1    Thompson, S.M.2
  • 5
    • 0033391029 scopus 로고    scopus 로고
    • Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia
    • Song XJ, Hu SJ, Greenquist KW, Zhang JM, LaMotte RH (1999) Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol 82:3347-3358.
    • (1999) J Neurophysiol , vol.82 , pp. 3347-3358
    • Song, X.J.1    Hu, S.J.2    Greenquist, K.W.3    Zhang, J.M.4    Lamotte, R.H.5
  • 6
    • 0034175686 scopus 로고    scopus 로고
    • Tactile allodynia in the absence of C-fiber activation: Altered firing properties of DRG neurons following spinal nerve injury
    • Liu CN, et al. (2000) Tactile allodynia in the absence of C-fiber activation: Altered firing properties of DRG neurons following spinal nerve injury. Pain 85:503-521.
    • (2000) Pain , vol.85 , pp. 503-521
    • Liu, C.N.1
  • 8
    • 0036260539 scopus 로고    scopus 로고
    • The clinico-radiological paradox in multiple sclerosis revisited
    • Barkhof F (2002) The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin Neurol 15:239-245.
    • (2002) Curr Opin Neurol , vol.15 , pp. 239-245
    • Barkhof, F.1
  • 9
    • 0018886528 scopus 로고
    • Paroxysmal symptoms as the first manifestations of multiple sclerosis
    • Twomey JA, Espir MLE (1980) Paroxysmal symptoms as the first manifestations of multiple sclerosis. J Neurol Neurosurg Psychiatry 43:296-304.
    • (1980) J Neurol Neurosurg Psychiatry , vol.43 , pp. 296-304
    • Twomey, J.A.1    Espir, M.L.E.2
  • 10
    • 0019762239 scopus 로고
    • Hyperexcitability of pathologically myelinated axons and positive symptoms in multiple sclerosis
    • Rasminsky M (1981) Hyperexcitability of pathologically myelinated axons and positive symptoms in multiple sclerosis. Adv Neurol 31:289-297.
    • (1981) Adv Neurol , vol.31 , pp. 289-297
    • Rasminsky, M.1
  • 11
    • 0020489848 scopus 로고
    • Membranes, myelin, and the pathophysiology of multiple sclerosis
    • Waxman SG (1982) Membranes, myelin, and the pathophysiology of multiple sclerosis. N Engl J Med 306:1529-1533.
    • (1982) N Engl J Med , vol.306 , pp. 1529-1533
    • Waxman, S.G.1
  • 13
    • 0020959632 scopus 로고
    • The optic nerve in MS: A morphological study with retrospective clinicopathological correlation
    • Ulrich J, Groebke-LorenzW (1983) The optic nerve in MS: A morphological study with retrospective clinicopathological correlation. Neuro-Ophthalmology 3:149-159.
    • (1983) Neuro-Ophthalmology , vol.3 , pp. 149-159
    • Ulrich, J.1    Groebke-Lorenz, W.2
  • 14
    • 0017902740 scopus 로고
    • The internodal axon membrane: Electrical excitability and continuous conduction in segmental demyelination
    • Bostock H, Sears TA (1978) The internodal axon membrane: Electrical excitability and continuous conduction in segmental demyelination. J Physiol 280:273-301.
    • (1978) J Physiol , vol.280 , pp. 273-301
    • Bostock, H.1    Sears, T.A.2
  • 15
    • 33947546463 scopus 로고    scopus 로고
    • Sodium channels and multiple sclerosis: Roles in symptom production, damage and therapy
    • Smith KJ (2007) Sodium channels and multiple sclerosis: Roles in symptom production, damage and therapy. Brain Pathol 17:230-242.
    • (2007) Brain Pathol , vol.17 , pp. 230-242
    • Smith, K.J.1
  • 16
    • 33751180140 scopus 로고    scopus 로고
    • Axonal conduction and injury in multiple sclerosis: The role of sodium channels
    • Waxman SG (2006) Axonal conduction and injury in multiple sclerosis: The role of sodium channels. Nat Rev Neurosci 7:932-941.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 932-941
    • Waxman, S.G.1
  • 17
    • 42349085463 scopus 로고    scopus 로고
    • Plasticity of intrinsic neuronal properties in CNS disorders
    • Beck H, Yaari Y (2008) Plasticity of intrinsic neuronal properties in CNS disorders. Nat Rev Neurosci 9:357-369.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 357-369
    • Beck, H.1    Yaari, Y.2
  • 18
    • 0021891177 scopus 로고
    • Activity-dependent excitability changes in normal and demyelinated rat spinal root axons
    • Bostock H, Grafe P (1985) Activity-dependent excitability changes in normal and demyelinated rat spinal root axons. J Physiol 365:239-257.
    • (1985) J Physiol , vol.365 , pp. 239-257
    • Bostock, H.1    Grafe, P.2
  • 19
    • 0026773253 scopus 로고
    • Ectopic activity in demyelinated spinal root axons of the rat
    • Baker M, Bostock H (1992) Ectopic activity in demyelinated spinal root axons of the rat. J Physiol 451:539-552.
    • (1992) J Physiol , vol.451 , pp. 539-552
    • Baker, M.1    Bostock, H.2
  • 20
    • 0034333301 scopus 로고    scopus 로고
    • Axonal flip-flops and oscillators
    • Baker MD
    • Baker MD (2000) Axonal flip-flops and oscillators. Trends Neurosci 23:514-519.
    • (2000) Trends Neurosci , vol.23 , pp. 514-519
  • 21
    • 0025836349 scopus 로고
    • A computational test of the requirements for conduction in demyelinated axons
    • Hines M, Shrager P (1991) A computational test of the requirements for conduction in demyelinated axons. Restor Neurol Neurosci 3:81-93.
    • (1991) Restor Neurol Neurosci , vol.3 , pp. 81-93
    • Hines, M.1    Shrager, P.2
  • 22
    • 0029584238 scopus 로고
    • A model of spike initiation in neocortical pyramidal neurons
    • Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-1439.
    • (1995) Neuron , vol.15 , pp. 1427-1439
    • Mainen, Z.F.1    Joerges, J.2    Huguenard, J.R.3    Sejnowski, T.J.4
  • 24
    • 33847126550 scopus 로고    scopus 로고
    • Seizure-like afterdischarges simulated in a model neuron
    • Kager H, Wadman WJ, Somjen GG (2007) Seizure-like afterdischarges simulated in a model neuron. J Comput Neurosci 22:105-128.
    • (2007) J Comput Neurosci , vol.22 , pp. 105-128
    • Kager, H.1    Wadman, W.J.2    Somjen, G.G.3
  • 25
    • 0017879728 scopus 로고
    • Conduction through demyelinated plaques in multiple sclerosis: Computer simulations of facilitation by short internodes
    • Waxman SG, Brill MH (1978) Conduction through demyelinated plaques in multiple sclerosis: Computer simulations of facilitation by short internodes. J Neurol Neurosurg Psychiatry 41:408-416.
    • (1978) J Neurol Neurosurg Psychiatry , vol.41 , pp. 408-416
    • Waxman, S.G.1    Brill, M.H.2
  • 26
    • 63849291098 scopus 로고    scopus 로고
    • From working memory to epilepsy: Dynamics of facilitation and inhibition in a cortical network
    • Verduzco-Flores S, Ermentrout B, BodnerM (2009) From working memory to epilepsy: Dynamics of facilitation and inhibition in a cortical network. Chaos 19:015115.
    • (2009) Chaos , vol.19 , pp. 015115
    • Verduzco-Flores, S.1    Ermentrout, B.2    Bodner, M.3
  • 27
    • 40549117895 scopus 로고    scopus 로고
    • Current management of pain associated with multiple sclerosis
    • Pöllmann W, Feneberg W (2008) Current management of pain associated with multiple sclerosis. CNS Drugs 22:291-324.
    • (2008) CNS Drugs , vol.22 , pp. 291-324
    • Pöllmann, W.1    Feneberg, W.2
  • 28
    • 57049166472 scopus 로고    scopus 로고
    • Tuning of synaptic integration in the medial entorhinal cortex to the organization of grid cell firing fields
    • Garden DLF, Dodson PD, O'Donnell C, White MD, Nolan MF (2008) Tuning of synaptic integration in the medial entorhinal cortex to the organization of grid cell firing fields. Neuron 60:875-889.
    • (2008) Neuron , vol.60 , pp. 875-889
    • Garden, D.L.F.1    Dodson, P.D.2    O'Donnell, C.3    White, M.D.4    Nolan, M.F.5
  • 29
    • 57449106633 scopus 로고    scopus 로고
    • The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice
    • Meuth SG, et al. (2009) The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice. Neurobiol Dis 33:1-11.
    • (2009) Neurobiol Dis , vol.33 , pp. 1-11
    • Meuth, S.G.1
  • 30
    • 0028223075 scopus 로고
    • Muscarinic inhibition of two potassium currents in guinea-pig prevertebral neurons: Differentiation by extracellular cesium
    • Coggan JS, Purnyn SL, Knoper SR, Kreulen DL (1994) Muscarinic inhibition of two potassium currents in guinea-pig prevertebral neurons: Differentiation by extracellular cesium. Neuroscience 59:349-361.
    • (1994) Neuroscience , vol.59 , pp. 349-361
    • Coggan, J.S.1    Purnyn, S.L.2    Knoper, S.R.3    Kreulen, D.L.4
  • 31
    • 0000783215 scopus 로고
    • The action of acetylcholine on conduction in mammalian non-myelinated fibres and its prevention by an anticholinesterase
    • Armett CJ, Ritchie JM (1960) The action of acetylcholine on conduction in mammalian non-myelinated fibres and its prevention by an anticholinesterase. J Physiol 152:141-158.
    • (1960) J Physiol , vol.152 , pp. 141-158
    • Armett, C.J.1    Ritchie, J.M.2
  • 33
    • 0036158792 scopus 로고    scopus 로고
    • Oscillatory mechanism in primary sensory neurones
    • Amir R, Liu CN, Kocsis JD, Devor M (2002) Oscillatory mechanism in primary sensory neurones. Brain 125:421-435.
    • (2002) Brain , vol.125 , pp. 421-435
    • Amir, R.1    Liu, C.N.2    Kocsis, J.D.3    Devor, M.4
  • 34
    • 0022657941 scopus 로고
    • Different effects of 4-aminopyridine on sensory and motor fibers: Pathogenesis of paresthesias
    • Kocsis JD, Bowe CM, Waxman SG (1986) Different effects of 4-aminopyridine on sensory and motor fibers: Pathogenesis of paresthesias. Neurology 36:117-120.
    • (1986) Neurology , vol.36 , pp. 117-120
    • Kocsis, J.D.1    Bowe, C.M.2    Waxman, S.G.3
  • 35
    • 33646776060 scopus 로고    scopus 로고
    • Potassium channel blockers in multiple sclerosis: Neuronal Kv channels and effects of symptomatic treatment
    • Judge SI, Bever CT, Jr. (2006) Potassium channel blockers in multiple sclerosis: Neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther 111: 224-259.
    • (2006) Pharmacol Ther , vol.111 , pp. 224-259
    • Judge, S.I.1    Bever Jr., C.T.2
  • 36
    • 0029087706 scopus 로고
    • Trigeminal neuralgia in multiple sclerosis
    • Hooge JP, Redekop WK (1995) Trigeminal neuralgia in multiple sclerosis. Neurology 45:1294-1296.
    • (1995) Neurology , vol.45 , pp. 1294-1296
    • Hooge, J.P.1    Redekop, W.K.2
  • 37
    • 0033556582 scopus 로고    scopus 로고
    • Positive symptoms in multiple sclerosis: Their treatment with sodium channel blockers, lidocaine and mexiletine
    • Sakurai M, Kanazawa I (1999) Positive symptoms in multiple sclerosis: Their treatment with sodium channel blockers, lidocaine and mexiletine. J Neurol Sci 162:162-168.
    • (1999) J Neurol Sci , vol.162 , pp. 162-168
    • Sakurai, M.1    Kanazawa, I.2
  • 38
    • 0031571202 scopus 로고    scopus 로고
    • The NEURON simulation environment
    • Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-1209.
    • (1997) Neural Comput , vol.9 , pp. 1179-1209
    • Hines, M.L.1    Carnevale, N.T.2
  • 39
    • 21344448644 scopus 로고    scopus 로고
    • Development of a model for microphysiological simulations: Small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography
    • Sosinsky GE, et al. (2005) Development of a model for microphysiological simulations: Small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography. Neuroinformatics 3:133-162.
    • (2005) Neuroinformatics , vol.3 , pp. 133-162
    • Sosinsky, G.E.1
  • 40
    • 0025817191 scopus 로고
    • Two types of fast K+ channels in rat myelinated nerve fibres and their sensitivity to dendrotoxin
    • Corrette BJ, Repp H, Dreyer F, Schwarz JR (1991) Two types of fast K+ channels in rat myelinated nerve fibres and their sensitivity to dendrotoxin. Pflugers Arch 418: 408-416.
    • (1991) Pflugers Arch , vol.418 , pp. 408-416
    • Corrette, B.J.1    Repp, H.2    Dreyer, F.3    Schwarz, J.R.4
  • 41
    • 0037780537 scopus 로고    scopus 로고
    • Kv3.1b is a novel component of CNS nodes
    • Devaux J, et al. (2003) Kv3.1b is a novel component of CNS nodes. J Neurosci 23: 4509-4518.
    • (2003) J Neurosci , vol.23 , pp. 4509-4518
    • Devaux, J.1
  • 42
    • 0032523747 scopus 로고    scopus 로고
    • Contribution of the Kv3.1 potassium channel to high frequency firing in mouse auditory neurones
    • DOI 10.1111/j.1469-7793.1998.183bo.x
    • Wang LY, Gan L, Forsythe ID, Kaczmarek LK (1998) Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. J Physiol 509:183-194. (Pubitemid 28252021)
    • (1998) Journal of Physiology , vol.509 , Issue.1 , pp. 183-194
    • Wang, L.-Y.1    Gan, L.2    Forsythe, I.D.3    Kaczmarek, L.K.4
  • 44
    • 0036090017 scopus 로고    scopus 로고
    • Modeling the excitability of mammalian nerve fibers: Influence of afterpotentials on the recovery cycle
    • McIntyre CC, Richardson AG, Grill WM (2002) Modeling the excitability of mammalian nerve fibers: Influence of afterpotentials on the recovery cycle. J Neurophysiol 87: 995-1006.
    • (2002) J Neurophysiol , vol.87 , pp. 995-1006
    • McIntyre, C.C.1    Richardson, A.G.2    Grill, W.M.3
  • 45
    • 0019405994 scopus 로고
    • Voltage oscillations in the barnacle giant muscle fiber
    • Morris C, Lecar H (1981) Voltage oscillations in the barnacle giant muscle fiber. Biophys J 35:193-213.
    • (1981) Biophys J , vol.35 , pp. 193-213
    • Morris, C.1    Lecar, H.2
  • 46
    • 0002453062 scopus 로고    scopus 로고
    • Analysis of neural excitability and oscillations
    • eds Koch C, Segev I (MIT Press, Cambridge, MA)
    • Rinzel J, Ermentrout GB (1998) Analysis of neural excitability and oscillations. Methods in Neuronal Modeling: From Ions to Networks, eds Koch C, Segev I (MIT Press, Cambridge, MA), pp 251-291.
    • (1998) Methods in Neuronal Modeling: From Ions to Networks , pp. 251-291
    • Rinzel, J.1    Ermentrout, G.B.2
  • 47
    • 55449122549 scopus 로고    scopus 로고
    • Biophysical basis for three distinct dynamical mechanisms of action potential initiation
    • Prescott SA, De Koninck Y, Sejnowski TJ (2008) Biophysical basis for three distinct dynamical mechanisms of action potential initiation. PLOS Comput Biol 4:e1000198.
    • (2008) PLOS Comput Biol , vol.4
    • Prescott, S.A.1    De Koninck, Y.2    Sejnowski, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.