Development of gelatin microspheres loaded with diclofenac sodium for intra-articular administration

Journal of Drug Targeting

Volumn 19, Issue 2, 2011, Pages 96-103

  Saravanan, Muniyandy ^a   Bhaskar, Kesavan ^b   Maharajan, Gomathinayagam ^c   Pillai, Kalathil Sadasivan ^d  

^a MONASH UNIVERSITY MALAYSIA   (Malaysia)

^b VELS INSTITUTE OF SCIENCE   (India)

^c CHETTINAD HOSPITAL AND RESEARCH INSTITUTE   (India)

^d Frontier Tissueline Pvt Ltd   (India)

Author keywords

Depot injection; Diclofenac sodium; Gelatin microspheres; Intra articular administration; Targeted delivery

Indexed keywords

DICLOFENAC; GELATIN; GLUTARALDEHYDE; MICROSPHERE;

ARTICLE; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; EMULSION; GAS CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DICLOFENAC; DRUG DELIVERY SYSTEMS; GELATIN; GLUTARAL; INJECTIONS, INTRA-ARTICULAR; MICROSPHERES; PARTICLE SIZE; RABBITS; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 78650564215     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/10611861003733979     Document Type: Article

References (16)

1. Bozdag S, Calis S, Kas HS, Ercan MT, Peksoy I, Hincal AA. (2001). In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium. J Microencapsul, 18, 443-456. (Pubitemid 32577120)
2. Brown KE, Leong K, Huang CH, Dalal R, Green GD, Haimes HB, Jimenez PA, Bathon J. (1998). Gelatin/chondroitin 6-sulfate microspheres for the delivery of therapeutic proteins to the joint. Arthritis Rheum, 41, 2185-2195. (Pubitemid 29009376)
3. Carson J, Notis WM, Orris ES. (1990). Colonic ulceration and bleeding during diclofenac therapy. N Engl J Med, 323, 135. (Pubitemid 20221664)
4. Costa P, Sousa Lobo JM. (2001). Modeling and comparison of dissolution profiles. Eur J Pharm Sci, 13, 123-133. (Pubitemid 32288781)
5. Larsen C, Ostergaard J, Larsen SW, Jensen H, Jacobsen S, Lindegaard C, Andersen PH. (2008). Intra-articular depot formulation principles: Role in the management of postoperative pain and arthritic disorders. J Pharm Sci, 97, 4622-4654.
6. Öner L, Groves MJ. (1993). Optimization of conditions for preparing 2- to 5-micron-range gelatin microparticles by using chilled dehydration agents. Pharm Res, 10, 621-626. (Pubitemid 23113060)
7. Patrick JS. (2006). Martins Physical Pharmacy and Pharmaceutical Sciences. 5th ed. Baltimore, MD: Lippincott Williams & Wilkins.
8. Pavanetto F, Genta I, Giunchedi P, Conti B, Conte U. (1994). Spraydried albumin microspheres for the intra-articular delivery of dexamethasone. J Microencapsul, 11, 445-454. (Pubitemid 24209459)
9. Ratcliffe JH, Hunneyball IM, Smith A, Wilson CG, Davis SS. (1984). Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs. J Pharm Pharmacol, 36, 431-436. (Pubitemid 14076429)
10. Ratcliffe JH, Hunneyball IM, Wilson CG, Smith A, Davis SS. (1987). Albumin microspheres for intra-articular drug delivery: Investigation of their retention in normal and arthritic knee joints of rabbits. J Pharm Pharmacol, 39, 290-295.
11. Saravanan M, Akhilesh Vijay V, Pradeep Kumar PD, Sushma A, Priya S, Maharajan G, Sadasivan Pillai K, Pandey S. (2008a). Comparative studies on diclofenac sodium loaded albumin/gelatin magnetic microspheres for intra-arterial administration. Acta Pharm Sciencia, 50, 189-195. (Pubitemid 351935734)
12. Saravanan M, Anbu J, Maharajan G, Pillai KS. (2008b). Targeted delivery of diclofenac sodium via gelatin magnetic microspheres formulated for intra-arterial administration. J Drug Target, 16, 366-378. (Pubitemid 351935734)
13. Saravanan M, Bhaskar K, Maharajan G, Pillai KS. (2004). Ultrasonically controlled release and targeted delivery of diclofenac sodium via gelatin magnetic microspheres. Int J Pharm, 283, 71-82. (Pubitemid 39200928)
14. Saravanan M, Bhaskar K, Narayanan NV, Maharajan G, Pillai KS. (2003). Diclofenac sodium loaded gelatin magnetic microspheres for intra-arterial administration: Formulation, characterization and in vitro release studies. Boll Chim Farm, 142, 347-351.
15. Tunçay M, Calis S, Kas HS, Ercan MT, Peksoy I, Hincal AA. (2000a). In vitro and in vivo evaluation of diclofenac sodium loaded albumin microspheres. J Microencapsul, 17, 145-155. (Pubitemid 30135792)
16. Tunçay M, Calis S, Kas HS, Ercan MT, Peksoy I, Hincal AA. (2000b). Diclofenac sodium incorporated PLGA (50:50) microspheres: Formulation considerations and in vitro/in vivo evaluation. Int J Pharm, 195, 179-188. (Pubitemid 30089502)