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Volumn 12, Issue 8, 2010, Pages 825-833

Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: A 31-phosphorus magnetic resonance spectroscopy study at 4T

Author keywords

Bipolar disorder; Epilepsy; Magnetic resonance spectroscopy; Phospholipids; Uridine

Indexed keywords

GLYCEROPHOSPHOETHANOLAMINE; GLYCEROPHOSPHORYLCHOLINE; MEMBRANE PHOSPHOLIPID; PHOSPHOETHANOLAMINE; PHOSPHORYLCHOLINE; URIDINE;

EID: 78650552248     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/j.1399-5618.2010.00884.x     Document Type: Article
Times cited : (11)

References (42)
  • 1
    • 0033791814 scopus 로고    scopus 로고
    • Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids
    • Klein J. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids. J Neural Transm 2000; 107: 1027-1063.
    • (2000) J Neural Transm , vol.107 , pp. 1027-1063
    • Klein, J.1
  • 2
    • 0031553042 scopus 로고    scopus 로고
    • CTP:phosphocholine cytidylyltransferase
    • Kent C. CTP:phosphocholine cytidylyltransferase. Biochim Biophys Acta 1997; 1348: 79-90.
    • (1997) Biochim Biophys Acta , vol.1348 , pp. 79-90
    • Kent, C.1
  • 3
    • 50949084838 scopus 로고    scopus 로고
    • Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids
    • Vance JE. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. J Lipid Res 2008; 49: 1377-1387.
    • (2008) J Lipid Res , vol.49 , pp. 1377-1387
    • Vance, J.E.1
  • 4
    • 33847378878 scopus 로고    scopus 로고
    • The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist
    • Eyster KM. The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist. Adv Physiol Educ 2007; 31: 5-16.
    • (2007) Adv Physiol Educ , vol.31 , pp. 5-16
    • Eyster, K.M.1
  • 5
    • 2342572271 scopus 로고    scopus 로고
    • Phospholipid biosynthesis in mammalian cells
    • Vance JE, Vance DE. Phospholipid biosynthesis in mammalian cells. Biochem Cell Biol 2004; 82: 113-128.
    • (2004) Biochem Cell Biol , vol.82 , pp. 113-128
    • Vance, J.E.1    Vance, D.E.2
  • 6
    • 61449152986 scopus 로고    scopus 로고
    • Phosphatidylinositol metabolism and membrane fusion
    • Poccia D, Larijani B. Phosphatidylinositol metabolism and membrane fusion. Biochem J 2009; 418: 233-246.
    • (2009) Biochem J , vol.418 , pp. 233-246
    • Poccia, D.1    Larijani, B.2
  • 7
    • 61449226468 scopus 로고    scopus 로고
    • Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand
    • Gohil VM, Greenberg ML. Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand. J Cell Biol 2009; 184: 469-472.
    • (2009) J Cell Biol , vol.184 , pp. 469-472
    • Gohil, V.M.1    Greenberg, M.L.2
  • 8
    • 0031026288 scopus 로고    scopus 로고
    • Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases
    • Exton JH. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases. Eur J Biochem 1997; 243: 10-20.
    • (1997) Eur J Biochem , vol.243 , pp. 10-20
    • Exton, J.H.1
  • 9
    • 0035688703 scopus 로고    scopus 로고
    • Lipid metabolism and vesicle trafficking: more than just greasing the transport machinery
    • McMaster CR. Lipid metabolism and vesicle trafficking: more than just greasing the transport machinery. Biochem Cell Biol 2001; 79: 681-692.
    • (2001) Biochem Cell Biol , vol.79 , pp. 681-692
    • McMaster, C.R.1
  • 10
    • 0032521171 scopus 로고    scopus 로고
    • How is membrane phospholipid biosynthesis controlled in neural tissues?
    • Araki W, Wurtman RJ. How is membrane phospholipid biosynthesis controlled in neural tissues?. J Neurosci Res 1998; 51: 667-674.
    • (1998) J Neurosci Res , vol.51 , pp. 667-674
    • Araki, W.1    Wurtman, R.J.2
  • 11
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipides
    • Kennedy EP, Weiss SB. The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem 1956; 222: 193-214.
    • (1956) J Biol Chem , vol.222 , pp. 193-214
    • Kennedy, E.P.1    Weiss, S.B.2
  • 12
    • 42649145405 scopus 로고    scopus 로고
    • Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation
    • Lecca D, Ceruti S. Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation. Biochem Pharmacol 2008; 75: 1869-1881.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1869-1881
    • Lecca, D.1    Ceruti, S.2
  • 13
    • 0028835448 scopus 로고
    • Effect of cytidine on membrane phospholipid synthesis in rat striatal slices
    • Savci V, Wurtman RJ. Effect of cytidine on membrane phospholipid synthesis in rat striatal slices. J Neurochem 1995; 64: 378-384.
    • (1995) J Neurochem , vol.64 , pp. 378-384
    • Savci, V.1    Wurtman, R.J.2
  • 14
    • 0026637566 scopus 로고
    • Enhancement by cytidine of membrane phospholipid synthesis
    • G-Coviella IL, Wurtman RJ. Enhancement by cytidine of membrane phospholipid synthesis. J Neurochem 1992; 59: 338-343.
    • (1992) J Neurochem , vol.59 , pp. 338-343
    • G-Coviella, I.L.1    Wurtman, R.J.2
  • 15
    • 0020326450 scopus 로고
    • Choline administration elevates brain phosphorylcholine concentrations
    • Millington WR, Wurtman RJ. Choline administration elevates brain phosphorylcholine concentrations. J Neurochem 1982; 38: 1748-1752.
    • (1982) J Neurochem , vol.38 , pp. 1748-1752
    • Millington, W.R.1    Wurtman, R.J.2
  • 16
    • 37549068147 scopus 로고    scopus 로고
    • Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release
    • Ulus IH, Watkins CJ, Cansev M, Wurtman RJ. Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cell Mol Neurobiol 2006; 26: 563-577.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 563-577
    • Ulus, I.H.1    Watkins, C.J.2    Cansev, M.3    Wurtman, R.J.4
  • 17
    • 0034308088 scopus 로고    scopus 로고
    • Effect of oral CDP-choline on plasma choline and uridine levels in humans
    • Wurtman RJ, Regan M, Ulus I, Yu L. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol 2000; 60: 989-992.
    • (2000) Biochem Pharmacol , vol.60 , pp. 989-992
    • Wurtman, R.J.1    Regan, M.2    Ulus, I.3    Yu, L.4
  • 18
    • 33747886010 scopus 로고    scopus 로고
    • Uridine and cytidine in the brain: their transport and utilization
    • Cansev M. Uridine and cytidine in the brain: their transport and utilization. Brain Res Rev 2006; 52: 389-397.
    • (2006) Brain Res Rev , vol.52 , pp. 389-397
    • Cansev, M.1
  • 19
    • 55949089964 scopus 로고    scopus 로고
    • High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides
    • Schwarz E, Prabakaran S, Whitfield P et al. High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides. J Proteome Res 2008; 7: 4266-4277.
    • (2008) J Proteome Res , vol.7 , pp. 4266-4277
    • Schwarz, E.1    Prabakaran, S.2    Whitfield, P.3
  • 20
    • 67349265673 scopus 로고    scopus 로고
    • Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: implications for pathophysiology
    • Green P, Anyakoha N, Yadid G, Gispan-Herman I, Nicolaou A. Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: implications for pathophysiology. Prostaglandins Leukot Essent Fatty Acids 2009; 80: 213-220.
    • (2009) Prostaglandins Leukot Essent Fatty Acids , vol.80 , pp. 213-220
    • Green, P.1    Anyakoha, N.2    Yadid, G.3    Gispan-Herman, I.4    Nicolaou, A.5
  • 21
    • 0035972848 scopus 로고    scopus 로고
    • 31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis
    • Yildiz A, Sachs GS, Dorer DJ, Renshaw PF. 31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis. Psychiatry Res 2001; 106: 181-191.
    • (2001) Psychiatry Res , vol.106 , pp. 181-191
    • Yildiz, A.1    Sachs, G.S.2    Dorer, D.J.3    Renshaw, P.F.4
  • 22
    • 0026453704 scopus 로고
    • Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy
    • Kato T, Takahashi S, Shioiri T, Inubushi T. Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord 1992; 26: 223-230.
    • (1992) J Affect Disord , vol.26 , pp. 223-230
    • Kato, T.1    Takahashi, S.2    Shioiri, T.3    Inubushi, T.4
  • 23
    • 0029036333 scopus 로고
    • Abnormal frontal lobe phosphorous metabolism in bipolar disorder
    • Deicken RF, Fein G, Weiner MW. Abnormal frontal lobe phosphorous metabolism in bipolar disorder. Am J Psychiatry 1995; 152: 915-918.
    • (1995) Am J Psychiatry , vol.152 , pp. 915-918
    • Deicken, R.F.1    Fein, G.2    Weiner, M.W.3
  • 24
    • 0027339579 scopus 로고
    • Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy
    • Kato T, Takahashi S, Shioiri T, Inubushi T. Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. J Affect Disord 1993; 27: 53-59.
    • (1993) J Affect Disord , vol.27 , pp. 53-59
    • Kato, T.1    Takahashi, S.2    Shioiri, T.3    Inubushi, T.4
  • 25
    • 13444254125 scopus 로고    scopus 로고
    • Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats
    • Carlezon WA Jr, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Biol Psychiatry 2005; 57: 343-350.
    • (2005) Biol Psychiatry , vol.57 , pp. 343-350
    • Carlezon Jr, W.A.1    Mague, S.D.2    Parow, A.M.3    Stoll, A.L.4    Cohen, B.M.5    Renshaw, P.F.6
  • 26
    • 78650527962 scopus 로고    scopus 로고
    • Note
    • Repligen Corp. RG2417: Targeting a novel mechanism to treat bipolar depression. Last accessed 18 November 2010.
  • 27
    • 33744498912 scopus 로고    scopus 로고
    • Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
    • Epperson CN, Gueorguieva R, Czarkowski KA et al. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology 2006; 186: 425-433.
    • (2006) Psychopharmacology , vol.186 , pp. 425-433
    • Epperson, C.N.1    Gueorguieva, R.2    Czarkowski, K.A.3
  • 28
    • 67349196438 scopus 로고    scopus 로고
    • Decreased glutamate/glutamine levels may mediate cytidine's efficacy in treating bipolar depression: a longitudinal proton magnetic resonance spectroscopy study
    • Yoon SJ, Lyoo IK, Haws C, Kim TS, Cohen BM, Renshaw PF. Decreased glutamate/glutamine levels may mediate cytidine's efficacy in treating bipolar depression: a longitudinal proton magnetic resonance spectroscopy study. Neuropsychopharmacology 2009; 34: 1810-1818.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 1810-1818
    • Yoon, S.J.1    Lyoo, I.K.2    Haws, C.3    Kim, T.S.4    Cohen, B.M.5    Renshaw, P.F.6
  • 29
    • 0028434609 scopus 로고
    • A novel sampling method for 31P spectroscopic imaging with improved sensitivity, resolution, and sidelobe suppression
    • Ponder SL, Twieg DB. A novel sampling method for 31P spectroscopic imaging with improved sensitivity, resolution, and sidelobe suppression. J Magn Reson B 1994; 104: 85-88.
    • (1994) J Magn Reson B , vol.104 , pp. 85-88
    • Ponder, S.L.1    Twieg, D.B.2
  • 30
    • 0036687942 scopus 로고    scopus 로고
    • In vivo brain (31)P-MRS: measuring the phospholipid resonances at 4 Tesla from small voxels
    • Jensen JE, Drost DJ, Menon RS, Williamson PC. In vivo brain (31)P-MRS: measuring the phospholipid resonances at 4 Tesla from small voxels. NMR Biomed 2002; 15: 338-347.
    • (2002) NMR Biomed , vol.15 , pp. 338-347
    • Jensen, J.E.1    Drost, D.J.2    Menon, R.S.3    Williamson, P.C.4
  • 31
    • 0024269943 scopus 로고
    • Kinetic and biochemical properties of CTP:choline-phosphate cytidylyltransferase from the rat brain
    • Mages F, Rey C, Fonlupt P, Pacheco H. Kinetic and biochemical properties of CTP:choline-phosphate cytidylyltransferase from the rat brain. Eur J Biochem 1988; 178: 367-372.
    • (1988) Eur J Biochem , vol.178 , pp. 367-372
    • Mages, F.1    Rey, C.2    Fonlupt, P.3    Pacheco, H.4
  • 32
    • 0344500821 scopus 로고    scopus 로고
    • Cytidine diphosphate choline administration activates brain cytidine triphosphate: phosphocholine cytidylytransferase in aged rats
    • Gimenez R, Soler S, Aguilar J. Cytidine diphosphate choline administration activates brain cytidine triphosphate: phosphocholine cytidylytransferase in aged rats. Neurosci Lett 1999; 273: 163-166.
    • (1999) Neurosci Lett , vol.273 , pp. 163-166
    • Gimenez, R.1    Soler, S.2    Aguilar, J.3
  • 33
    • 0025134479 scopus 로고
    • Boehringer Mannheim Award lecture Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly
    • Vance DE. Boehringer Mannheim Award lecture Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly. Biochem Cell Biol 1990; 68: 1151-1165.
    • (1990) Biochem Cell Biol , vol.68 , pp. 1151-1165
    • Vance, D.E.1
  • 34
    • 0026500225 scopus 로고
    • Evidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a decrease in cellular diacylglycerol levels in cultured rat hepatocytes
    • Jamil H, Utal AK, Vance DE. Evidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a decrease in cellular diacylglycerol levels in cultured rat hepatocytes. J Biol Chem 1992; 267: 1752-1760.
    • (1992) J Biol Chem , vol.267 , pp. 1752-1760
    • Jamil, H.1    Utal, A.K.2    Vance, D.E.3
  • 35
    • 0033515558 scopus 로고    scopus 로고
    • Cellular responses to excess phospholipid
    • Baburina I, Jackowski S. Cellular responses to excess phospholipid. J Biol Chem 1999; 274: 9400-9408.
    • (1999) J Biol Chem , vol.274 , pp. 9400-9408
    • Baburina, I.1    Jackowski, S.2
  • 36
    • 59849104558 scopus 로고    scopus 로고
    • Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy
    • Silveri MM, Dikan J, Ross AJ et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed 2008; 21: 1066-1075.
    • (2008) NMR Biomed , vol.21 , pp. 1066-1075
    • Silveri, M.M.1    Dikan, J.2    Ross, A.J.3
  • 37
    • 0035991074 scopus 로고    scopus 로고
    • Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study
    • Babb SM, Wald LL, Cohen BM et al. Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology 2002; 161: 248-254.
    • (2002) Psychopharmacology , vol.161 , pp. 248-254
    • Babb, S.M.1    Wald, L.L.2    Cohen, B.M.3
  • 38
    • 44949161985 scopus 로고    scopus 로고
    • Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients
    • Jensen JE, Daniels M, Haws C et al. Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients. Exp Clin Psychopharmacol 2008; 16: 199-206.
    • (2008) Exp Clin Psychopharmacol , vol.16 , pp. 199-206
    • Jensen, J.E.1    Daniels, M.2    Haws, C.3
  • 39
    • 27144492384 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research
    • Stork C, Renshaw PF. Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol Psychiatry 2005; 10: 900-919.
    • (2005) Mol Psychiatry , vol.10 , pp. 900-919
    • Stork, C.1    Renshaw, P.F.2
  • 40
    • 77952670205 scopus 로고    scopus 로고
    • MRI-related anxiety levels change within and between repeated scanning sessions
    • Chapman HA, Bernier D, Rusak B. MRI-related anxiety levels change within and between repeated scanning sessions. Psychiatry Res 2010; 182: 160-164.
    • (2010) Psychiatry Res , vol.182 , pp. 160-164
    • Chapman, H.A.1    Bernier, D.2    Rusak, B.3
  • 41
    • 0029738515 scopus 로고    scopus 로고
    • Cerebral glucose metabolism during pharmacologic studies: test-retest under placebo conditions
    • Schmidt ME, Ernst M, Matochik JA et al. Cerebral glucose metabolism during pharmacologic studies: test-retest under placebo conditions. J Nucl Med 1996; 37: 1142-1149.
    • (1996) J Nucl Med , vol.37 , pp. 1142-1149
    • Schmidt, M.E.1    Ernst, M.2    Matochik, J.A.3
  • 42
    • 23444445642 scopus 로고    scopus 로고
    • Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats
    • Wang L, Pooler AM, Albrecht MA, Wurtman RJ. Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci 2005; 27: 137-145.
    • (2005) J Mol Neurosci , vol.27 , pp. 137-145
    • Wang, L.1    Pooler, A.M.2    Albrecht, M.A.3    Wurtman, R.J.4


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