Redundancy of the influenza A virus-specific cytotoxic T lymphocyte response in HLA-B*2705 transgenic mice limits the impact of a mutation in the immunodominant NP383-391 epitope on influenza pathogenesis

Virus Research

Volumn 155, Issue 1, 2011, Pages 123-130

  Bodewes, R ^a   Geelhoed Mieras, M M ^a   Nieuwkoop, N J ^a   Hanson, J A ^b   David, C S ^b   Fouchier, R A M ^a   Osterhaus, A D M E ^a   Rimmelzwaan, G F ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

2705 Transgenic mice; Cytotoxic T lymphocytes; HLA B; Influenza

Indexed keywords

ARGININE; EPITOPE; GLYCINAMIDE; HLA B ANTIGEN; HLA B2705 ANTIGEN; NUCLEOPROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; IN VIVO STUDY; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS A; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; VIRAL CLEARANCE; VIRUS MUTATION; VIRUS VIRULENCE; WEIGHT REDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; BODY WEIGHT; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; HLA-B27 ANTIGEN; IMMUNODOMINANT EPITOPES; INFLUENZA A VIRUS, H3N2 SUBTYPE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION, MISSENSE; ORTHOMYXOVIRIDAE INFECTIONS; RNA-BINDING PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VIRAL CORE PROTEINS;

INFLUENZA A VIRUS; MUS; MUS MUSCULUS; ORTHOMYXOVIRIDAE;

EID: 78650551800     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2010.09.008     Document Type: Article

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