Lissencephaly-1 controls germline stem cell self- renewal through modulating bone morphogenetic protein signaling and niche adhesion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 46, 2010, Pages 19939-19944

  Chen, Shuyi ^a,b   Kaneko, Satoshi ^c   Ma, Xing ^a,b   Chen, Xiaochu ^c   Ip, Y Tony ^c   Xu, Lan ^a,c   Xie, Ting ^a,b  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BRAIN DEVELOPMENT; CELL ADHESION; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CONFERENCE PAPER; CONTROLLED STUDY; DROSOPHILA; GENE; GENE CONTROL; GERM LINE; IMMUNOHISTOCHEMISTRY; LISSENCEPHALY 1 GENE; MUTANT; NERVE CELL; NEUROMODULATION; NONHUMAN; OVARY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; STEM CELL; WILD TYPE;

MAMMALIA;

EID: 78650533560     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008606107     Document Type: Article

References (32)

1. Morrison SJ, Spradling AC (2008) Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life. Cell 132:598-611.
2. Li L, Xie T (2005) Stem cell niche: Structure and function. Annu Rev Cell Dev Biol 21:605-631.
3. Xi R, Kirilly D, Xie T (2005) Molecular mechanisms controlling germline and somatic stem cells: Similarities and differences. Curr Opin Genet Dev 15:381-387.
4. Fuchs E, Tumbar T, Guasch G (2004) Socializing with the neighbors: Stem cells and their niche. Cell 116:769-778.
5. Kirilly D, Xie T (2007) The Drosophila ovary: An active stem cell community. Cell Res 17:15-25.
6. Xie T, Spradling AC (2000) A niche maintaining germ line stem cells in the Drosophila ovary. Science 290:328-330.
7. Xie T, Spradling AC (1998) Decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94:251-260.
8. Decotto E, Spradling AC (2005) The Drosophila ovarian and testis stem cell niches: Similar somatic stem cells and signals. Dev Cell 9:501-510.
9. Lin H, Yue L, Spradling AC (1994) The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation. Development 120:947-956.
10. Song X, et al. (2004) Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development 131:1353-1364.
11. Chen D, McKearin D (2003) Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Curr Biol 13:1786-1791.
12. Song X, Zhu CH, Doan C, Xie T (2002) Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science 296:1855-1857.
13. Jin Z, et al. (2008) Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell 2:39-49.
14. Wynshaw-Boris A, Gambello MJ (2001) LIS1 and dynein motor function in neuronal migration and development. Genes Dev 15:639-651.
15. Feng Y, Walsh CA (2001) Protein-protein interactions, cytoskeletal regulation and neuronal migration. Nat Rev Neurosci 2:408-416.
16. Siller KH, Doe CQ (2008) Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts. Dev Biol 319:1-9.
17. Liu Z, Steward R, Luo L (2000) Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. Nat Cell Biol 2:776-783.
18. Liu Z, Xie T, Steward R (1999) Lis1 ,theDrosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation. Development 126:4477-4488.
19. Lei Y, Warrior R (2000) The Drosophila Lissencephaly1 (DLis1) gene is required for nuclear migration. Dev Biol 226:57-72.
20. Swan A, Nguyen T, Suter B (1999) Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Nat Cell Biol 1:444-449.
21. Hebbar S, et al. (2008) Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. J Cell Biol 182:1063-1071.
22. Yingling J,et al. (2008) Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell 132:474-486.
23. Cheng J, et al. (2008) Centrosome misorientation reduces stem cell division during ageing. Nature 456:599-604.
24. Deng W, Lin H (1997) Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila. Dev Biol 189:79-94.
25. Affolter M, Basler K (2007) The Decapentaplegic morphogen gradient: From pattern formation to growth regulation. Nat Rev Genet 8:663-674.
26. Penton A, et al. (1994) Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell 78:239-250.
27. Nellen D, Affolter M, Basler K (1994) Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78:225-237.
28. Shen R, Weng C, Yu J, Xie T (2009) eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. Proc Natl Acad Sci USA 106:11623-11628.
29. Shimmi O, Umulis D, Othmer H, O'Connor MB (2005) Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. Cell 120:873-886.
30. Letsou A, et al. (1995) Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGF beta receptor family. Cell 80:899-908.
31. Ruberte E, Marty T, Nellen D, Affolter M, Basler K (1995) An absolute requirement for both the type II and type I receptors, punt and thick veins,fordpp signaling in vivo. Cell 80:889-897.
32. Zhu CH, Xie T (2003) Clonal expansion of ovarian germline stem cells during niche formation in Drosophila. Development 130:2579-2588.