Long-term swimming exercise does not modulate the Akt-dependent endothelial nitric oxide synthase phosphorylation in healthy mice

Canadian Journal of Physiology and Pharmacology

Volumn 89, Issue 1, 2011, Pages 72-76

  Pellegrin, Maxime ^a,b   Miguet Alfonsi, Carole ^b   Berthelot, Alain ^a   Laurant, Lucia Mazzolai Pascal ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b Faculté de Médecine Pharmacie   (France)

Author keywords

Akt mediated eNOS phosphorylation; Healthy mice; Long term exercise

Indexed keywords

CD31 ANTIGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXERCISE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITTING; SWIMMING; WESTERN BLOTTING;

ANIMALS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; SWIMMING; TIME FACTORS;

EID: 78650528194     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y10-107     Document Type: Article

References (17)

1. Boo, Y.C., and Jo, H. 2003. Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. Am. J. Physiol. Cell Physiol. 285(3): C499-C508. PMID:12900384.
2. Delp, M.D., and Laughlin, M.H. 1997. Time course of enhanced endothelium-mediated dilation in aorta of trained rats. Med. Sci. Sports Exerc. 29(11): 1454-1461. PMID:9372482.
3. Fleming, I., Fisslthaler, B., Dixit, M., and Busse, R. 2005. Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells. J. Cell Sci. 118(18): 4103-4111. doi:10.1242/jcs.02541. PMID:16118242.
4. Graham, D.A., and Rush, J.W. 2004. Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J. Appl. Physiol. 96(6): 2088-2096. doi:10.1152/japplphysiol. 01252.2003. PMID:14752124.
5. Hambrecht, R., Adams, V., Erbs, S., Linke, A., Kränkel, N., Shu, Y., et al. 2003. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation, 107(25): 3152-3158. doi:10.1161/01.CIR.0000074229.93804.5C. PMID:12810615.
6. Kadoglou, N.P., Iliadis, F., and Liapis, C.D. 2008. Exercise and carotid atherosclerosis. Eur. J. Vasc. Endovasc. Surg. 35(3): 264-272. doi:10.1016/j.ejvs.2007.08.022. PMID:17988901.
7. Kojda, G., Cheng, Y.C., Burchfield, J., and Harrison, D.G. 2001. Dysfunctional regulation of endothelial nitric oxide synthase (eNOS) expression in response to exercise in mice lacking one eNOS gene. Circulation, 103(23): 2839-2844. PMID:11401942.
8. Laufs, U., Wassmann, S., Czech, T., Munzel, T., Eisenhauer, M., Bohm, M., and Nickenig, G. 2005. Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 25(4): 809-814. doi:10.1161/01. ATV.0000158311.24443.af. PMID:15692095.
9. Maiorana, A., O'Driscoll, G., Taylor, R., and Green, D. 2003. Exercise and the nitric oxide vasodilator system. Sports Med. 33(14): 1013-1035. doi:10.2165/00007256-200333140-00001. PMID:14599231.
10. McAllister, R.M., Jasperse, J.L., and Laughlin, M.H. 2005. Nonuniform effects of endurance exercise training on vasodilation in rat skeletal muscle. J. Appl. Physiol. 98(2): 753-761. doi:10.1152/ japplphysiol.01263.2003. PMID:15448126.
11. Moien-Afshari, F., Ghosh, S., Khazaei, M., Kieffer, T.J., Brownsey, R.W., and Laher, I. 2008. Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. Diabetologia, 51(7): 1327-1337. doi:10.1007/s00125-0080996-x. PMID:18437348.
12. pellegrin, M., Berthelot, A., Houdayer, C., Gaume, V., Deckert, V., and Laurant, P. 2007. New insights into the vascular mechanisms underlying the beneficial effect of swimming training on the endothelial vasodilator function in apolipoprotein E-deficient mice. Atherosclerosis, 190(1): 35-42. doi:10.1016/j. atherosclerosis.2006.02.001. PMID:16529753.
13. pellegrin, M., Miguet-Alfonsi, C., Bouzourene, K., Aubert, J.F., Deckert, V., Berthelot, A., et al. 2009. Long-term exercise stabilizes atherosclerotic plaque in ApoE knockout mice. Med. Sci. Sports Exerc. 41(12): 2128-2135. doi:10.1249/MSS.0b013e3181a8d530. PMID:19915507.
14. Spier, S.A., Delp, M.D., Meininger, C.J., Donato, A.J., Ramsey, M.W., and Muller-Delp, J.M. 2004. Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles. J. Physiol. 556(3): 947-958. doi:10.1113/jphysiol.2003.060301. PMID:15004211.
15. Tanabe, T., Maeda, S., Miyauchi, T., Iemitsu, M., Takanashi, M., Irukayama-Tomobe, Y., et al. 2003. Exercise training improves ageing-induced decrease in eNOS expression of the aorta. Acta Physiol. Scand. 178(1): 3-10. doi:10.1046/j.1365-201X.2003. 01100.x. PMID:12713509.
16. Yang, Z., and Ming, X.F. 2006. Recent advances in understanding endothelial dysfunction in atherosclerosis. Clin. Med. Res. 4(1): 53-65. doi:10.3121/cmr.4.1.53. PMID:16595793.
17. Zanesco, A., and Antunes, E. 2007. Effects of exercise training on the cardiovascular system: pharmacological approaches. Pharmacol. Ther. 114(3): 307-317. doi:10.1016/j.pharmthera.2007.03. 010. PMID:17512599.