The identification of cellular targets of 17β estradiol using a lytic (T7) cDNA phage display approach

Toxicology in Vitro

Volumn 25, Issue 1, 2011, Pages 388-393

  Van Dorst Bieke, B ^a,b   Mehta, Jaytry ^a,b   Rouah Martin, Elsa ^a,b   Coen, Wim De ^a   Blust, Ronny ^a   Robbens, Johan ^a,b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b INSTITUTE FOR AGRICULTURAL AND FISHERIES RESEARCH ILVO   (Belgium)

Author keywords

17 estradiol; CDNA phage display; Cellular targets; Lytic (T7) phage; Mechanism of action

Indexed keywords

ATP SYNTHASE F0 SUBUNIT 6; BECLIN 1; BINDING PROTEIN; COMPLEMENTARY DNA; ESTRADIOL; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; BINDING AFFINITY; BREAST; COMPLEMENTARY DNA PHAGE LIBRARY; CONTROLLED STUDY; DISSOCIATION CONSTANT; ESTROGEN BINDING; HUMAN; HUMAN TISSUE; PHAGE DISPLAY; PROTEIN ANALYSIS; PROTEIN TARGETING; SURFACE PLASMON RESONANCE;

APOPTOSIS REGULATORY PROTEINS; BACTERIOPHAGE T7; DNA, COMPLEMENTARY; DRUG EVALUATION, PRECLINICAL; ESTRADIOL; ESTROGENS; FEMALE; HUMANS; KINETICS; MAMMARY GLANDS, HUMAN; MEMBRANE PROTEINS; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MOLECULAR TARGETED THERAPY; PEPTIDE LIBRARY; PROTEIN BINDING;

EID: 78650524459     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.10.012     Document Type: Article

References (25)

1. Aita V.M., Liang X.H., Murty V., Pincus D.L., Yu W.P., Cayanis E., Kalachikov S., Gilliam T.C., Levine B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999, 59:59-65.
2. Baker K., Sengupta D., Salazar-Jimenez G., Cornish V.W. An optimized dexamethasone-methotrexate yeast 3-hybrid system for high-throughput screening of small molecule-protein interactions. Analytical Biochemistry 2003, 315:134-137.
3. Bidlingmaier S., Liu B. Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins. Molecular & Cellular Proteomics 2007, 6:2012-2020.
4. Bradner J.E., McPherson O.M., Mazitschek R., Barnes-Seeman D., Shen J.P., Dhaliwal J., Stevenson K.E., Duffner J.L., Park S.B., Neuberg D.S., Nghiem P., Schreiber S.L., Koehler A.N. A robust small-molecule microarray platform for screening cell lysates. Chemistry & Biology 2006, 13:493-504.
5. Caligiuri M., Molz L., Liu Q., Kaplan F., Xu J.P., Majeti J.Z., Ramos-Kelsey R., Murthi K., Lievens S., Tavernier J., Kley N. Maspit: three-hybrid trap for quantitative proteome fingerprinting of small molecule-protein interactions in mammalian cells. Chemistry & Biology 2006, 13:711-722.
6. Jin Y., Yu J., Yu Y.G. Identification of hnopp140 as a binding partner for doxorubicin with a phage display cloning method. Chemistry & Biology 2002, 9:157-162.
7. John S., Nayvelt I., Hsu H.C., Yang P.A., Liu W.S., Das G.M., Thomas T., Thomas T.J. Regulation of estrogenic effects by beclin 1 in breast cancer cells. Cancer Research 2008, 68:7855-7863.
8. Kley N. Chemical dimerizers and three-hybrid systems: scanning the proteome for targets of organic small molecules. Chemistry & Biology 2004, 11:599-608.
9. Kroemer G., Levine B. Autophagic cell death: the story of a misnomer. Nature Reviews Molecular Cell Biology 2008, 9:1004-1010.
10. Liang X.H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676.
11. Makowski L., Rodi D.J. Genome-wide characterisation of the binding repertoire of small molecule drugs. Human Genomics 2003, 1:41-51.
12. Malmborg A.C. Phage display method. In real-time analysis of biomolecular interactions. Applications of Biacore 2000, 187-194. Springer, Tokyo. K. Nagata, H. Handa (Eds.).
13. Massart F., Paolini S., Piscitelli E., Brandi M.L., Solaini G. Dose-dependent inhibition of mitochondrial atp synthase by 17 beta-estradiol. Gynecological Endocrinology 2002, 16:373-377.
14. 0 proton channel of rat-liver mitochondria - rapid purification of a functional complex and a study of its interaction with the unique probe diethylstilbestrol. Journal of Biological Chemistry 1989, 264:12029-12036.
15. McEnery M.W., Pedersen P.L. Diethylstilbestrol - a novel fo-directed probe of the mitochondrial proton atpase. Journal of Biological Chemistry 1986, 261:1745-1752.
16. Ramanov V.I. Phage display selection and evaluation of cancer drug targets. Cancer drug targets 2003, 3:119-129.
17. Rix U., Superti-Furga G. Target profiling of small molecules by chemical proteomics. Nature Chemical Biology 2009, 5:616-624.
18. Sche P.P., McKenzie K.M., White J.D., Austin D.J. Display cloning: functional identification of natural product receptors using cDNA-phage display. Chemistry & Biology 1999, 6:707-716.
19. Takakusagi Y., Takakusagi K., Sugawara F., Sakaguchi K. Use of phage display technology for the determination of the targets for small-molecule therapeutics. Expert Opinion on Drug Discovery 2010, 5:361-389.
20. Van Dorst B., Mehta J., Rouah-Martin E., Somers V., De Coen W., Blust R., Robbens J. cDNA phage display as a novel tool to screen for cellular targets of chemical compounds. Toxicology in Vitro 2010, 24:1435-1440.
21. Yu X.M., Zhao P., Zhang W.B., Zhang L.H., Zhang Y.K. Screening of phage displayed human liver cDNA library against dexamethasone. Journal of Pharmaceutical and Biomedical Analysis 2007, 45:701-705.
22. Zhang C.C., Glenn K.A., Kuntz M.A., Shapiro D.J. High level expression of full-length estrogen receptor in Escherichia coli is facilitated by the uncoupler of oxidative phosphorylation, cccp. Journal of Steroid Biochemistry and Molecular Biology 2000, 74:169-178.
23. Zhang Y.Z., Lv Z.B., Chen J., Chen Q., Quan Y.P., Kong L.Y., Zhang H.H., Li S., Zheng Q.L., Chen J.Q., Nie Z.M., Wang J., Jin Y.F., Wu X.F. A novel method for isolation of membrane proteins: a baculovirus surface display system. Proteomics 2008, 8:4178-4185.
24. 1-atp synthase/atpase. Journal of Steroid Biochemistry and Molecular Biology 1999, 68:65-75.
25. +-atpase of porcine cortex. European Journal of Pharmacology 1999, 368:95-102.