Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 546-549

  Dong, Yizhou ^a   Nakagawa Goto, Kyoko ^a   Lai, Chin Yu ^a   Morris Natschke, Susan L ^a   Bastow, Kenneth F ^a   Lee, Kuo Hsiung ^a,b  

^a University of North Carolina   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

4 Amino 7,8,9,10 tetrahydro 2H benzo h chromen 2 ones (ATBO); Cytotoxic activity; Neo tanshinlactone

Indexed keywords

4 AMINO 2H BENZO[H]CHROMEN 2 ONE; 4 AMINO 7,8,9,10 TETRAHYDRO 2H BENZO[H]CHROMEN 2 ONE; ANTINEOPLASTIC AGENT; NEO TANSHINLACTONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHROMONES; COUMARINS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650520385     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.074     Document Type: Article

References (15)

1. H. Bleicher Konrad, H.-J. Bohm, K. Muller, and I. Alanine Alexander Nat. Rev. Drug Disc. 2 2003 369
2. P. Vallance, P. Williams, and C. Dollery Clin. Pharmacol. Ther. 87 2010 525
3. B. Hughes Nat. Rev. Drug Disc. 9 2010 89
4. D. Crommelin, P. Stolk, L. Besancon, V. Shah, K. Midha, and H. Leufkens Nat. Rev. Drug Disc. 9 2010 99
5. X. Wang, K.F. Bastow, C.M. Sun, Y.L. Lin, H.J. Yu, M.J. Don, T.S. Wu, S. Nakamura, and K.H. Lee J. Med. Chem. 47 2004 5816
6. X. Wang, K. Nakagawa-Goto, K.F. Bastow, M.J. Don, Y.L. Lin, T.S. Wu, and K.H. Lee J. Med. Chem. 49 2006 5631
7. D.S. Kim, C.G. Dong, J.T. Kim, H. Guo, J. Huang, P.S. Tiseni, and Y. Kishi J. Am. Chem. Soc. 131 2009 15636
8. Y. Dong, Q. Shi, Y.-N. Liu, X. Wang, K.F. Bastow, and K.-H. Lee J. Med. Chem. 52 2009 3586
9. Y. Dong, Q. Shi, K. Nakagawa-Goto, P.-C. Wu, S.L. Morris-Natschke, A. Brossi, K.F. Bastow, J.-Y. Lang, M.-C. Hung, and K.-H. Lee Bioorg. Med. Chem. 18 2010 803
10. Y. Dong, Q. Shi, K. Nakagawa-Goto, P.C. Wu, K.F. Bastow, S.L. Morris-Natschke, and K.H. Lee Bioorg. Med. Chem. Lett. 19 2009 6289
11. Y. Dong, K. Nakagawa-Goto, C.Y. Lai, S.L. Morris-Natschke, K.F. Bastow, and K.H. Lee Bioorg. Med. Chem. Lett. 20 2010 4085
12. M. Di Braccio, G. Grossi, G. Roma, C. Marzano, F. Baccichetti, M. Simonato, and F. Bordin Farmaco 58 2003 1083
13. A. Alberola, R. Alvaro, A.G. Ortega, M.L. Sadaba, and M.C. Sanudo Tetrahedron 55 1999 13211
14. Solubility of 12-14 and 16-18 in DMSO is not very great. Work is ongoing to solve the solubility issue and results will be reported in due course.
15. +-1). 4-(cyclohexylamino)-7, 8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (11)