The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10- diones: Synthesis and anti-proliferative characteristics

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 423-428

  Shchekotikhin, Andrey E ^a   Glazunova, Valeria A ^b   Dezhenkova, Lyubov G ^a   Shevtsova, Elena K ^c   Traven', Valery F ^c   Balzarini, Jan ^d   Huang, Hsu Shan ^e   Shtil, Alexander A ^b   Preobrazhenskaya, Maria N ^a  

^a GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c MENDELEEV UNIVERSITY OF CHEMICAL TECHNOLOGY OF RUSSIA   (Russian Federation)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Anthra 2,3 b furan 5,10 diones; Cytotoxicity; Drug resistance; Topoisomerase I; Tumor cells

Indexed keywords

2 METHYL 4,11 BIS[2 (METHYLAMINO)ETHYLAMINO]ANTHRA[2,3 B]FURAN 5,10 DIONE DIHYDROCHLORIDE; 2 TERT BUTYL 4,11 BIS[2 (DIMETHYLAMINO)ETHYLAMINO]ANTHRA[2,3 B]FURAN 5,10 DIONE; 2 TERT BUTYL 4,11 BIS[2 (METHYLAMINO)ETHYLAMINO]ANTHRA[2,3 B]FURAN 5,10 DIONE; 4,11 BIS(2 AMINOETHYLAMINO) 2 METHYLANTHRA[2,3 B]FURAN 5,10 DIONE DIHYDROCHLORIDE; 4,11 BIS[(2 AMINOETHYL)AMINO]ANTHRA[2,3 B]FURAN 5,10 DIONE DERIVATIVE; 4,11 BIS[(2 GUANIDINOETHYL)AMINO] 2 METHYLANTHRA[2,3 B]FURAN 5,10 DIONE DIHYDROCHLORIDE; 4,11 BIS[2 (2 HYDROXYETHYLAMINO)ETHYLAMINO] 2 METHYLANTHRA[2,3 B]FURAN 5,10 DIONE DIHYDROCHLORIDE; 4,11 BIS[2 (DIMETHYLAMINO)ETHYLAMINO] 2 METHYLANTHRA[2,3 B]FURAN 5,10 DIONE DIHYDROCHLORIDE; 4,11 DIAMINOANTHRATHRA[2,3 B]FURAN 5,10 DIONE DERIVATIVE; 4,11 DIPROPOXYANTHRA[2,3 B]FURAN 5,10 DIONE DERIVATIVE; AMETANTRONE; ANTHRA[2,3 B]FURAN 5,10 DIONE DERIVATIVE; ANTHRAFURANDIONE DERIVATIVE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA; DNA TOPOISOMERASE; DOXORUBICIN; ETHYLENEDIAMINE DERIVATIVE; FURAN DERIVATIVE; GLYCOPROTEIN P; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONCENTRATION (PARAMETERS); CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE DELETION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE I; DRUG RESISTANCE, NEOPLASM; FURANS; HUMANS; INHIBITORY CONCENTRATION 50; NUCLEIC ACID CONFORMATION; PYRROLES; THIOPHENES;

EID: 78650516622     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.017     Document Type: Article

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