Radiolabeling and preliminary biological evaluation of a 99mTc(CO)3 labeled 3,3′-(benzylidene)-bis-(1H- indole-2-carbohydrazide) derivative as a potential SPECT tracer for in vivo visualization of necrosis

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 502-505

  Prinsen, Kristof ^a   Jin, Lixin ^a,b   Vunckx, Kathleen ^a,b   De Saint Hubert, Marijke ^a,b   Zhou, Lin ^a,b   Cleynhens, Jan ^a   Nuyts, Johan ^a,b   Bormans, Guy ^a   Ni, Yicheng ^a,b   Verbruggen, Alfons ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

99mTc(CO)3; Benzylidene bis indole; Cell death; Necrosis; SPECT

Indexed keywords

ALCOHOL; FAS LIGAND; N',N' BIS(DIETHYLENETRIAMINE PENTAACETIC ACID) 3,3' (BENZYLIDENE) BIS (1H INDOLE 2 CARBOHYDRAZIDE) CARBON TRIOXIDE TC 99M; TRACER; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; DRUG UPTAKE; IN VIVO STUDY; ISOTOPE LABELING; LIVER NECROSIS; LIVER PERFUSION; MUSCLE NECROSIS; NONHUMAN; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; APOPTOSIS; HEPATOCYTES; INDOLES; ISOTOPE LABELING; MICE; NECROSIS; ORGANOTECHNETIUM COMPOUNDS; PENTETIC ACID; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

RATTUS NORVEGICUS;

EID: 78650516124     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.102     Document Type: Article

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