3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: Hit to lead studies

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 195-199

  Gilbert, Adam M ^a   Bursavich, Matthew G ^a   Lombardi, Sabrina ^a   Adedoyin, Adedayo ^a   Dwyer, Jason M ^a   Hughes, Zoe ^a   Kern, Jeffrey C ^a   Khawaja, Xavier ^a   Rosenzweig Lipson, Sharon ^a   Moore, William J ^a   Neal, Sarah J ^a   Olsen, Michael ^a   Rizzo, Stacey J Sukoff ^a   Springer, Dane ^a  

^a PFIZER INC   (United States)

Author keywords

Anxiolytic; LipE; mGluR5; Negative allosteric modulator

Indexed keywords

3 (PYRIDIN 2 YLETHYNYL)BENZAMIDE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; DOG; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; RAT;

ALLOSTERIC REGULATION; ANIMALS; ANXIETY DISORDERS; BENZAMIDES; DISEASE MODELS, ANIMAL; HIGH-THROUGHPUT SCREENING ASSAYS; MICE; PYRIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE;

RATTUS;

EID: 78650515367     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.038     Document Type: Article

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