Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology

Chemical Engineering Journal

Volumn 166, Issue 2, 2011, Pages 726-737

  Lau, Sie Yon ^a   Gonawan, Fadzil Noor ^a   Bhatia, Subhash ^a   Kamaruddin, Azlina Harun ^a   Uzir, Mohamad Hekarl ^a  

^a SCHOOL OF CHEMICAL ENGINEERING   (Malaysia)

Author keywords

Dynamic kinetic resolution; Enzyme mediated membrane reactor; Ibuprofen; Lipase; Simulation

Indexed keywords

A PLANTS; ASPEN PLUS; CHIRAL DRUGS; DESIGN AND SIMULATION; DYNAMIC KINETIC RESOLUTION; HIGH PURITY; IBUPROFEN; MASS AND ENERGY BALANCE; MEMBRANE REACTOR; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; OPTIMUM OPERATING CONDITIONS; PHARMACEUTICAL PRODUCTS; PILOT-SCALE PRODUCTION; PROCESS SIMULATION SOFTWARE; PRODUCT CRYSTALS; PRODUCT PURIFICATION; SIMULATION; SUBSTRATE PREPARATION; TEMPERATURE RANGE; THREE-STEP PROCESS;

BIOREACTORS; COMPUTER SOFTWARE; CONCEPTUAL DESIGN; DRUG PRODUCTS; ENZYMES; ESTERIFICATION; ESTERS; INNOVATION; MEMBRANE TECHNOLOGY;

SUBSTRATES;

EID: 78650514640     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cej.2010.11.072     Document Type: Article

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