Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4- dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 145-149

  De Jonghe, Steven ^a   Marchand, Arnaud ^a   Gao, Ling Jie ^a   Calleja, Agnes ^a   Cuveliers, Eva ^a   Sienaert, Ilse ^a   Herman, Jean ^a   Clydesdale, Gavin ^a   Sefrioui, Hassane ^a   Lin, Yuan ^a   Pfleiderer, Wolfgang ^b   Waer, Mark ^c   Herdewijn, Piet ^d  

^a 4AZA Bioscience   (Belgium)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anti inflammatory drugs; Immunosuppressive drugs; Pteridine

Indexed keywords

2 AMINO 4 ALKOXY 6 CHLORO PTERIDINE; 2 AMINO 4 ALKOXY PTERIDINE; 2 AMINO 4 N PIPERAZINYL 6 (3,4 DIMETHOXYPHENYL) PTERIDINE; 2,6 DIAMINO 4 HYDROXY PYRIMIDINE; 6 (3,4 DIMETHOXYPHENYL) PTERIDINE; OXIDE; PTERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; DRUG SYNTHESIS; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; OXIDATION; T LYMPHOCYTE;

ANTI-INFLAMMATORY AGENTS; DRUG EVALUATION, PRECLINICAL; IMMUNOSUPPRESSIVE AGENTS; PTERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650512644     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.053     Document Type: Article

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