Immunization with newly transformed Schistosoma mansoni schistosomula tegument elicits tegument damage, reduction in egg and parasite burden

Parasite Immunology

Volumn 32, Issue 11-12, 2010, Pages 749-759

  Teixeira De Melo, T ^a   Michel De Araujo, J ^a   Do Valle Duraes F ^b   Caliari, M V ^b   Oliveira, S C ^b,c   Coelho, P M Z ^a   Fonseca, C T ^a,c  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c Inst Nacional de Ciência e Tecnologia em Doenças Tropicais   (Brazil)

Author keywords

Schistosoma mansoni; Schistosomula tegument; Vaccine

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; INTERLEUKIN 10; INTERLEUKIN 4; SCHISTOSOMA VACCINE; SCHISTOSOMULA TEGUMENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; EGG PARASITOID; FECES ANALYSIS; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHISTOSOMULUM; WORM TEGUMENT;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; FECES; FEMALE; FREUND'S ADJUVANT; LIVER; MICE; MICE, INBRED C57BL; PARASITE EGG COUNT; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; TH1 CELLS; VACCINES, SUBUNIT;

MUS; SCHISTOSOMA MANSONI;

EID: 78650507905     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2010.01244.x     Document Type: Article

References (52)

1. El Ridi R & Tallima H. Schistosoma mansoni ex vivo lung-stage larvae excretory-secretory antigens as vaccine candidates against schistosomiasis. Vaccine 2009; 27: 666-673.
2. Steinmann P, Keiser J, Bos J, Tanner M & Utzinger J. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis 2006; 6: 411-425.
3. Gryseels B, Polman K, Clerinx J & Kestens L. Human schistosomiasis. Lancet 2006; 368: 1106-1118.
4. Harder A. Chemotherapeutic approaches to schistosomes current knowledge and outlook. Parasitol Res 2002; 88: 395-397.
5. Fenwick A & Webster JP. Schistosomiasis: challenges for control, treatment and drug resistence. Curr Opin Infect Dis 2006; 19: 577-582.
6. Bergquist NR. Schistosomiasis vaccine development: appro-aches and prospects. Mem Inst Oswaldo Cruz 1995; 90: 221-227.
7. Thomas PG, Carter MR, Atochina O, et al. Maturation of dendritic cell 2 phenotype by a helminth glycan uses a toll-like receptor 4-dependent mechanism. J Immunol 2003; 171: 5837-5841.
8. Durães FV, Carvalho NB, Melo TT, Oliveira SC & Fonseca CT. IL-12 and TNF- α production by dendritic cells stimulated with Schistosoma mansoni schistosomula tegument is TLR4- and MyD88-dependent. Immunol Lett 2009; 125: 72-77.
9. + T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections. Immunology 1989; 67: 466-472.
10. Smythies LE, Coulson PS & Wilson RA. Monoclonal antibody to IFN-gamma modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae. J Immunol 1992; 149: 3654-3658.
11. Wilson RA, Coulson PS, Betis C, Dowking MA & Smythies LE. Impaired immunity and altered pulmonary response in mice with a disrupted interferon-γ receptor gene exposed to the irradiated Schistosoma mansoni vaccine. Immunology 1996; 87: 275-282.
12. Jankovic D, Wynn TA, Kullberg MC, et al. Optimal vaccination against Schistosoma mansoni requires the induction of both B cell and IFN-γ dependent effector mechanisms. J Immunol 1999; 162: 345-351.
13. Fonseca CT, Brito CF, Alves JB & Oliveira SC. IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN- γ and TNF- α dependent pathway. Vaccine 2004; 22: 503-510.
14. Wynn TA & Cheever AW. Cytokine regulation of granuloma formation in schistosomiasis. Curr Opin Immunol 1995; 7: 505-511.
15. Wynn TA, Cheever AW, Jankovic D, et al. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 1995; 376: 594-596.
16. Foley M, Kussel JR & Garland PB. Changes in the organization of the surface membrane upon transformation of cercariae to schistosomula of helminth parasite Schistosoma mansoni. Parasitology 1988; 96(Pt 1): 85-97.
17. James SL. In vitro proliferative response to living schistosomula by T lymphocytes from mice infected with Schistosoma mansoni. Parasitology 1981; 83(Pt 1): 147-162.
18. Simpson AJ, James SL & Sher A. Identification of surface antigens of schistosomula of Schistosoma mansoni recognized by antibodies from mice immunized by chronic infection and by exposure to highly irradiated cercariae. Infect Immun 1983; 41: 591-597.
19. Jones MK, Gobert GN, Zhang L, Sunderland P & McManaus DP. The cytoskeleton and motor proteins of human schistosomes and their roles in surface maintenance and host-parasite interactions. Bioessays 2004; 26: 752-765.
20. Van Hellemond JJ, Retra K, Brouwers JF, et al. Functions of the tegument of schistosomes: clues from the proteome and lipidome. Int J Parasitol 2006; 36: 691-699.
21. Tran MH, Pearson MS, Bethony JM, et al. Tetraspanin on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Nat Med 2006; 12: 835-840.
22. Cardoso FC, Macedo GC, Gava E, et al. Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection. Plos Negl Trop Dis 2008; 2: e308.
23. Ramalho-Pinto FJ, Gazzinelli G, Howells RE, Mota-Santos TA, Figueiredo EA & Pelegrino J. Schistosoma mansoni: defined system for stepwise transformation of cercariae to schistossomule in vitro. Exp Parasitol 1974; 36: 360-372.
24. Caldas IR, Correa-Oliveira R, Colosimo E, et al. Susceptibility and resistence to Schistosoma mansoni reinfection: parallel cellular and isotypic immunologic assessment. Am J Trop Med Hyg 2000; 62: 57-64.
25. Cardoso FC, Pacífico RN, Mortara RA & Oliveira SC. Human antibody responses of patients living in endemic áreas for schistosomiasis to the tegumental protein Sm29 identified through genomic studies. Clin Exp Immunol 2006; 144: 382-391.
26. Smithers SR & Terry RJ. The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adults worms. Parasitology 1965; 55: 695-700.
27. Pellegrino J & Siqueira AF. Técnica de perfusão para colheita de Schistosoma mansoni em cobaias experimentalmente infestadas. Rev Bras Malariol Doenças Trop 1956; 8: 589-597.
28. Hoffman WA, Pons JA & Janer JL. The sedimentation concentration method in schistosomiasis mansoni. Puerto Rico J Public Health 1934; 9: 281-298.
29. Jurberg AD, Oliveira AA, Lenzi HA & Coelho PMZ. A new miracidia hatching device for diagnosing schistosomiasis. Mem Inst Oswaldo Cruz 2008; 103: 112-114.
30. Sarvel AK, Kusel JR, Araújo N, Coelho PMZ & Katz N. Comparrison between morphological and staining characteristics of live and dead eggs of Schistosoma mansoni. Mem Inst Oswaldo Cruz 2006; 101(Suppl. 1): 289-292.
31. Jurberg AD, Gonçalves T, Costa TA, et al. The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system. Dev Genes Evol 2009; 219: 219-234.
32. Hewitson JP, Hamblin PA & Mountford AP. In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni. Infect Immun 2007; 75: 3539-3547.
33. Mountford AP, Anderson S & Wilson RA. Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co- administration of larval antigens and IL-12 as an adjuvant. J Immunol 1996; 156: 4739-4745.
34. James SL, Pearce EJ & Sher A. Induction of protective immunity against Schistosoma mansoni by a non living vaccine. I. Partial characterization of antigens recognized by antibodies from mice immunized with soluble schistosome extracts. J Immunol 1985; 134: 3432-3438.
35. Smithers SR, Hackett F, Omer AliP & Simpson AJG. Protective immunization of mice against Schistosoma mansoni with purified adult worm membranes. Parasite Immunol 1989; 11: 301-318.
36. Khalife J, Capron M, Grzych JM, Butterworth AE, Dunne DW & Ouma JH. Immunity in human schistosomiasis mansoni: regulation of protective immune mechanism by IgM blocking antibodies. J Exp Med 1986; 164: 1626-1640.
37. Capron A, Dessaint JP, Capron M & Bazin H. Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules. Nature 1975; 253: 474-475.
38. Joseph M, Auriault C, Capron A, Vorng H & Viens P. A new function for platelets: IgE dependent killing of schistosomules. Nature 1983; 303: 810-812.
39. Von Lichtenberg F, Correa-Oliveira R & Sher A. The fate of challenge schistosomula in the murine anti-schistosome vaccine model. Am J Trop Med Hyg 1985; 34: 96-106.
40. Wilson RA, Coulson PS & Dixon B. Migration of the schistosomula of Schistosoma mansoni in mice vaccinated with radiation-attenuated cercariae and normal mice: an attempt to identify the timing and site of parasite death. Parasitology 1986; 92: 101-116.
41. James SL, Cheever AW, Caspar P & Wynn TA. Inducible nitric oxide synthase-deficient mice develop enhanced Th1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistence. Infect Immun 1998; 66: 3510-3518.
42. Crabtree JE & Wilson RA. The role of pulmonary cellular reactions in the resistence of vaccinated mice to Schistosoma mansoni. Parasite Immunol 1986; 8: 265-285.
43. Coulson PS & Wilson RA. Examination of mechanisms of pulmonary phase resistance to Schistosoma mansoni in vaccinated mice. Am J Trop Med Hyg 1988; 38: 529-539.
44. Kassim OO, Dean DA, Mangold BL & Von Lichtenberg F. Combined microautoradiographic and histopathologic analysis of the fate of challenge Schistosoma mansoni schistosomula in mice immunized with irradiated cercariae. Am J Trop Med Hyg 1992; 47: 231-237.
45. Allam G. Vasoactive intestinal peptide inhibits liver pathology in acute murine schistosomiasis mansoni and modulates IL-10, IL-12 and TNF-alpha production. Immunobiology 2007; 212: 603-612.
46. Sadler CH, Rutitzky LI, Miguel JS & Wilson RA. IL-10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni. Eur J Immunol 2003; 33: 880-888.
47. DeKruyff RH, Mosmann RR & Umetsu DT. Induction of antibody synthesis by CD4+ T cells:IL-5 is essential for induction of antigen specific antibody response by Th2 but not Th1 clones. Eur J Immunol 1990; 20: 2219-2227.
48. Hewitson JP, Hamblin PA & Mountford AP. Immunity induced by the radiation-attenuated schistosome vaccine. Parasite Immunol 2005; 27: 271-280.
49. Fonseca CT, Pacífico LG, Barsante MM, Rassi T, Cassali GD & Oliveira SC. Co-administration of plasmid expressing IL-12 with 14-kDa Schistosoma mansoni fatty acid-binding protein cDNA alters immune response profiles and fails to enhance protection induced by Sm14 DNA vaccine alone. Microbes Infect 2006; 8: 2509-2516.
50. Garcia TC, Fonseca CT, Pacífico LG, et al. Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in mice. Acta Trop 2008; 106: 162-167.
51. McLaren DJ, Cleeg JA & Smithers SR. Acquisition of host antigens by young Schistosoma mansoni in mice: correlation with failure to bind antibody in vitro. Parasitology 1975; 70: 67-75.
52. Simpson AJ, Singer D, McCutchan TF, Sacks DL & Sher A. Evidence that schistosome MHC antigens are not synthesized by the parasite but are acquired from the host as intact glycoproteins. J Immunol 1983; 131: 962-965.