Why do we need a trial on the effects of testosterone therapy in older men?

Clinical Pharmacology and Therapeutics

Volumn 89, Issue 1, 2011, Pages 29-31

  Cook, N L ^a   Romashkan, S ^b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE;

AGING; COGNITION; DRUG EFFECT; GROUPS BY AGE; HUMAN; PRIORITY JOURNAL; REVIEW; SEXUAL FUNCTION; SUPPLEMENTATION; TESTOSTERONE BLOOD LEVEL;

AGED; AGED, 80 AND OVER; AGING; CLINICAL TRIALS AS TOPIC; EVIDENCE-BASED MEDICINE; HORMONE REPLACEMENT THERAPY; HUMANS; MALE; MEN'S HEALTH; OFF-LABEL USE; TESTOSTERONE;

EID: 78650507822     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2010.217     Document Type: Review

References (9)

1. Institute of Medicine. Testosterone and Aging: Clinical Research Directions (National Academies Press, Washington, DC, 2004).
2. Harman, S.M., Metter, E.J., Tobin, J.D., Pearson, J. & Blackman, M.R. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J. Clin. Endocrinol. Metab. 86, 724-731 (2001).
3. Hijazi, R.A. & Cunningham, G.R. Andropause: is androgen replacement therapy indicated for the aging male? Annu. Rev. Med. 56, 117-137 (2005).
4. Bhasin, S. The brave new world of function-promoting anabolic therapies: testosterone and frailty. J. Clin. Endocrinol. Metab. 95, 509-511 (2010).
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6. US Food and Drug Administration. Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology. Androgel® (testosterone) BPCA Drug Use Review http://www.Fda.Gov/downloads/AdvisoryCommittees/ CommitteesMeetingMaterials/PediatricAdvisoryCommittee/UCM166697.Pdf (4 February 2009).
7. Stanworth, R.D. & Jones, T.H. Testosterone for the aging male; current evidence and recommended practice. Clin. Interv. Aging 3, 25-44 (2008).
8. Fernández-Balsells, M.M. et al. Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 95, 2560-2575 (2010).
9. Basaria, S. et al. Adverse events associated with testosterone administration in a randomized, Placebo-controlled trial of older men with mobility limitation. N. Engl. J. Med. 363, 109-122 (2010).