Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 49, 2010, Pages 21122-21127

  Nord, Karolin H ^a   Magnusson, Linda ^a   Isaksson, Margareth ^a   Nilsson, Jenny ^a   Lilljebjörn, Henrik ^a   Domanski, Henryk A ^b   Kindblom, Lars Gunnar ^c,d   Mandahl, Nils ^a   Mertens, Fredrik ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c ROYAL ORTHOPAEDIC HOSPITAL   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Adipocytic tumor; Adipose tissue; Lipoma; SNP array; Soft tissue tumor

Indexed keywords

AIP GENE; ARTICLE; BROWN ADIPOSE TISSUE; CARCINOGENESIS; CHROMOSOME BREAKAGE; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HIBERNOMA; HUMAN; HUMAN TISSUE; MEN1 GENE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 78650489189     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013512107     Document Type: Article

References (24)

1. Miettinen MM, Fanburg-Smith JC, Mandahl N (2002) World Health Organization: Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone, eds Fletcher CDM, Unni KK, Mertens F (IARC Press, Lyon), pp 33-34.
2. Gisselsson D, Höglund M, Mertens F, Dal Cin P, Mandahl N (1999) Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics. Am J Pathol 155:61-66.
3. Maire G, et al. (2003) 11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5. Genes Chromosomes Cancer 37:389-395.
4. Timmons JA, et al. (2007) Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci USA 104: 4401-4406.
5. Malumbres M, Barbacid M (2009) Cell cycle, CDKs and cancer: A changing paradigm. Nat Rev Cancer 9:153-166.
6. Seale P, et al. (2008) PRDM16 controls a brown fat/skeletal muscle switch. Nature 454: 961-967.
7. Mitelman F, Johansson B, Mertens F (2007) The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer 7:233-245.
8. Karhu A, Aaltonen LA (2007) Susceptibility to pituitary neoplasia related to MEN-1, CDKN1B and AIP mutations: An update. Hum Mol Genet 16(Spec No 1):R73-R79.
9. Vortmeyer AO, Böni R, Pak E, Pack S, Zhuang Z (1998) Multiple endocrine neoplasia 1 gene alterations in MEN1-associated and sporadic lipomas. J Natl Cancer Inst 90: 398-399.
10. Dong Q, et al. (1997) Loss of heterozygosity at 11q13: Analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 82:1416-1420.
11. Vidal A, Iglesias MJ, Fernández B, Fonseca E, Cordido F (2008) Cutaneous lesions associated to multiple endocrine neoplasia syndrome type 1. J Eur Acad Dermatol Venereol 22:835-838.
12. Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH (2003) Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem 278: 4467-4473.
13. Dreijerink KM, et al. (2009) The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation. Mol Cell Biol 29:5060-5069.
14. Puigserver P, et al. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839.
15. Xue B, et al. (2007) Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 48:41-51.
16. Barberá MJ, et al. (2001) Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J Biol Chem 276:1486-1493.
17. Xue B, Coulter A, Rim JS, Koza RA, Kozak LP (2005) Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol Cell Biol 25:8311-8322.
18. Long GG, Reynolds VL, Dochterman LW, Ryan TE (2009) Neoplastic and non-neoplastic changes in F-344 rats treated with Naveglitazar, a gamma-dominant PPAR alpha/ gamma agonist. Toxicol Pathol 37:741-753.
19. Manieri M, Murano I, Fianchini A, Brunelli A, Cinti S (2009) Morphological and immunohistochemical features of brown adipocytes and preadipocytes in a case of human hibernoma. Nutr Metab Cardiovasc Dis 20:567-574.
20. Mertens F, et al. (1994) Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. Int J Cancer 58:503-505.
21. Bartuma H, et al. (2007) Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype. Genes Chromosomes Cancer 46:594-606.
22. Bartuma H, et al. (2009) Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups. Mol Cancer 8:36.
23. Dahlén A, et al. (2003) Clustering of deletions on chromosome 13 in benign and lowmalignant lipomatous tumors. Int J Cancer 103:616-623.
24. Vierimaa O, et al. (2006) Pituitary adenoma predisposition caused by germline mutations in the AIP gene. Science 312:1228-1230.