Association of androgen receptor CAG repeat polymorphism with VO2max response to hypoxic training in North China Han men

International Journal of Andrology

Volumn 33, Issue 6, 2010, Pages 794-799

  Wang, H Y ^a   Hu, Y ^a   Wang, S H ^b   Shan, Q L ^c   Li, Y C ^a   Nie, J ^d   Yi, L Y ^a   Bao, D P ^a   Xu, C Y ^a   He, Z H ^a  

^a BEIJING SPORT UNIVERSITY   (China)

^b INDIANA UNIVERSITY   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d JIANGXI NORMAL UNIVERSITY   (China)

Author keywords

Androgen receptor; CAG repeat polymorphism; Hypoxic training

Indexed keywords

ANDROGEN RECEPTOR; GENOMIC DNA;

ADULT; ALLELE; ALTITUDE; ARTICLE; BODY MASS; BODY WEIGHT; CAG REPEAT; CHINA; DNA POLYMORPHISM; EXERCISE; EXON; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RECEPTOR GENE;

ALTITUDE; ANOXIA; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; BODY WEIGHT; CHINA; EXERCISE; GENOTYPE; HUMANS; MALE; OXYGEN CONSUMPTION; POLYMORPHISM, GENETIC; RECEPTORS, ANDROGEN; TRINUCLEOTIDE REPEATS; YOUNG ADULT;

EID: 78650446660     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2009.01027.x     Document Type: Article

References (26)

1. Beilin, J., Ball, E. M., Favaloro, J. M. & Zajac, J. D. (2000) Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity: specificity in prostate and non-prostate cell lines. Journal of Molecular Endocrinology 25, 85-96.
2. Callewaert, L., Christiaens, V., Haelens, A., Verrijdt, G., Verhoeven, G. & Claessens, F. (2003) Implications of a polyglutamine tract in the function of the human androgen receptor. Biochemical and Biophysical Research Communications 20, 46-52.
3. Chamberlain, N. L., Driver, E. D. & Miesfeld, R. L. (1994) The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Research 22, 3181-3186.
4. Chang, C. Y. & McDonnell, D. P. (2005) Androgen receptor-cofactor interactions as targets for new drug discovery. Trends in Pharmacological Sciences 26, 225-228.
5. Choong, C. S. & Wilson, E. M. (1998) Trinucleotide repeats in the human androgen receptor: a molecular basis for disease. Journal of Molecular Endocrinology 21, 235-257.
6. Choong, C. S., Kemppainen, J. A., Zhou, Z. X. & Wilson, E. M. (1996) Reduced androgen receptor gene expression with first exon CAG repeat expansion. Journal of Molecular Endocrinology 10, 1527-1535.
7. Dejager, S., Bry-Gauillard, H., Bruckert, E., Eymard, B., Salachas, F., LeGuern, E., Tardieu, S., Chadarevian, R., Giral, P. & Turpin, G. (2002) A comprehensive endocrine description of Kennedy's disease revealing androgen insensitivity linked to CAG repeat length. The Journal of Clinical Endocrinology Metabolism 87, 3893-3901.
8. Edwards, A., Hammond, H. A., Jin, L., Caskey, C. T. & Chakroborty, R. (1992) Genetic variation at five trimeric and tetrameric tandom repeat loci in four human population groups. Genomics 12, 241-253.
9. Griffin, J. E. & Wilson, J. D. (1998) Disorders of the testes and the male reproductive tract. In: Williams Textbook of Endocrinology, 9th edn (eds J. D. Wilson, D. W. Foster, H. M. Kronenberg & P. R. Larsen ), pp. 819-875. WB Saunders Co., Philadelphia.
10. Gustafson, D. R., Wen, M. J. & Koppanati, B. M. (2003) Androgen receptor gene repeats and indices of obesity in older adults. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 27, 75-81.
11. Hartgens, F. & Kuipers, H. (2004) Effects of androgenic-anabolic steroids in athletes. Sports Medicine 34, 513-554.
12. Huhtaniemi, I. T., Pye, S. R., Limer, K. L., Thomson, W., O'Neill, T. W., Platt, H. & European Male Ageing Study Group. (2009) Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats. The Journal of Clinical Endocrinology and Metabolism 94, 277-284.
13. Kazemi-Esfarjani, P., Trifiro, M. A. & Pinsky, L. (1995) Evidence for a recessive function of the long polyglutamine tract in the human androgen receptor: possible pathogenetic relevance for the (CAG)n-expanded neuronopathies. Human Molecular Genetics 4, 523-527.
14. Lapauw, B., Goemaere, S., Crabbe, P., Kaufman, J. M. & Ruige, J. B. (2007) Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men? European Journal of Endocrinology 156, 395-401.
15. Palazzolo, I., Gliozzi, A., Rusmini, P., Sau, D., Crippa, V., Simonini, F., Onesto, E., Bolzoni, E. & Poletti, A. (2008) The role of the polyglutamine tract in androgen receptor. The Journal of Steroid Biochemistry and Molecular Biology 108, 245-253.
16. Preisler, N, Andersen, G, Thøgersen, F, Crone, C, Jeppesen, TD, Wibrand, F & Vissing, J. (2009) Effect of aerobic training in patients with spinal and bulbar muscular atrophy (Kennedy disease). Neurology 72, 317-323.
17. Stanworth, R. D., Kapoor, D., Channer, K. S. & Jones, T. H. (2008) Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes. European Journal of Endocrinology 159, 739-746.
18. Tilley, W. D., Marcelli, M., Wilson, J. D. & McPhaul, M. J. (1989) Characterization and expression of a cDNA encoding the human androgen receptor. Proceedings of the National Academy of Sciences of the United States of America 86, 327-331.
19. Tut, T. G., Ghadeesy, F. G., Trifiro, M. A., Pinsky, L. & Yong, E. L. (1997) Long polyglutamine tracts in the androgen receptor are associated with reduced transactivation, impaired sperm production, and male infertility. The Journal of Clinical Endocrinology and Metabolism 82, 3777-3782.
20. Walsh, S., Zmuda, J. M., Carley, J. A., Shea, P. R., Metter, E. J., Hurley, B. F. & Roth, S. M. (2005) Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men. Journal of Applied Physiology 98, 132-137.
21. Watson, J. D., Baker, T. A., Bell, S. P. & Alexander, G. Editor. Compiled by Yang Huanming. (2005) Molecular Biology of the Gene, 5th edn. Beijing Science Publishing House, Beijing, pp. 128-129.
22. Yeap, B. B., Wilce, J. A. & Leedman, P. J. (2004) The androgen receptor mRNA. BioEssays 26, 672-682.
23. Zitzmann, M. (2009) The role of CAG repeat androgen receptor polymorphism in andrology. Frontiers of Hormone Research 37, 52-61.
24. Zitzmann, M. & Nieschlag, E. (2003) The CAG repeat polymorphism within the androgen receptor gene and maleness. International Journal of Andrology 26, 76-83.
25. Zitzmann, M. & Nieschlag, E. (2007) Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal Men. The Journal of Clinical Endocrinology Metabolism 92, 3844-3853.
26. Zitzmann, M., Gromoll, J., Von Eckardstein, A. & Nieschlag, E. (2003) The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men. Diabetologia 46, 31-39.