메뉴 건너뛰기




Volumn 10, Issue 1, 2011, Pages 45-54

Gastrointestinal bleeding associated with low-dose aspirin use: Relevance and management in clinical practice

Author keywords

anti inflammatory agents; aspirin; bleeding; haemorrhage; non steroidal

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL;

EID: 78650443125     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740338.2010.507629     Document Type: Review
Times cited : (25)

References (58)
  • 1
    • 65849268320 scopus 로고    scopus 로고
    • Antithrombotic Trialists (ATT) Collaboration. Aspirin in the primary and secondary prevention pf vascular disease: Collaborative meta-analysis of individual participant data from randomised trials
    • Antithrombotic Trialists (ATT) Collaboration. Aspirin in the primary and secondary prevention pf vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009;373:1849-69
    • Lancet , vol.2009 , Issue.373 , pp. 1849-1869
  • 2
    • 74549176008 scopus 로고    scopus 로고
    • Aspirin for the primary prevention of stroke and myocardial infarction: Ineffective or wrong dose?
    • Dalen JE. Aspirin for the primary prevention of stroke and myocardial infarction: ineffective or wrong dose? Am J Med 2010;123:101-2
    • Am J Med , vol.2010 , Issue.123 , pp. 101-112
    • Dalen, J.E.1
  • 3
    • 61449176905 scopus 로고    scopus 로고
    • Expanding the recognition and assessment of bleeding events associated with antiplatelet therapy in primary care
    • Cohen M. Expanding the recognition and assessment of bleeding events associated with antiplatelet therapy in primary care. Mayo Clin Proc 2009;84:149-60
    • (2009) Mayo Clin Proc , vol.84 , pp. 149-160
    • Cohen, M.1
  • 4
    • 69349087916 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: A trip from peptic ulcer to colon cancer
    • Lanas A. Nonsteroidal anti-inflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: a trip from peptic ulcer to colon cancer. Am J Med Sci 2009;338:96-106
    • (2009) Am J Med Sci , vol.338 , pp. 96-106
    • Lanas, A.1
  • 5
    • 0033065324 scopus 로고    scopus 로고
    • Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans
    • DOI 10.1016/S0016-5085(99)70545-7
    • Cryer B, Feldman M. Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans. Gastroenterology 1999;117:17-25 (Pubitemid 29297615)
    • (1999) Gastroenterology , vol.117 , Issue.1 , pp. 17-25
    • Cryer, B.1    Feldman, M.2
  • 6
    • 70350223578 scopus 로고    scopus 로고
    • Circadian variations of gastrointestinal mucosal damage detected with transnasal endoscopy in apparently healthy subjects treated with low-dose aspirin (ASA) for a short period
    • Kawai T, Yamagishi T, Goto S. Circadian variations of gastrointestinal mucosal damage detected with transnasal endoscopy in apparently healthy subjects treated with low-dose aspirin (ASA) for a short period. J Atheroscler Thromb 2009;16:155-63
    • (2009) J Atheroscler Thromb , vol.16 , pp. 155-163
    • Kawai, T.1    Yamagishi, T.2    Goto, S.3
  • 7
    • 27644558549 scopus 로고    scopus 로고
    • Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin
    • Yeomans ND, Lanas AI, Talley NJ, et al. Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment Pharmacol Ther 2005;22:795-801
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 795-801
    • Yeomans, N.D.1    Lanas, A.I.2    Talley, N.J.3
  • 8
    • 0034638656 scopus 로고    scopus 로고
    • Risk of gastrointestinal haemorrhage with long term use of aspirin: Meta-analysis
    • Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7
    • (2000) BMJ , vol.321 , pp. 1183-1187
    • Derry, S.1    Loke, Y.K.2
  • 9
    • 0036113540 scopus 로고    scopus 로고
    • Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin
    • DOI 10.1046/j.1365-2036.2002.01230.x
    • Serrano P, Lanas A, Arroyo MT, Ferreira IJ. Risk of upper gastrointestinal bleeding in patients taking low-dose aspirin for the prevention of cardiovascular diseases. Aliment Pharmacol Ther 2002;16:1945-53 (Pubitemid 34407526)
    • (2002) Alimentary Pharmacology and Therapeutics , vol.16 , Issue.4 , pp. 779-786
    • Lanas, A.1    Fuentes, J.2    Benito, R.3    Serrano, P.4    Bajador, E.5    Sainz, R.6
  • 11
    • 85046588922 scopus 로고    scopus 로고
    • Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice
    • Lanas A, Garcia-Rodriguez LA, Polo-Tomas M, et al. Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol 2009;104:1633-41
    • (2009) Am J Gastroenterol , vol.104 , pp. 1633-1641
    • Lanas, A.1    Garcia-Rodriguez, L.A.2    Polo-Tomas, M.3
  • 12
    • 33750609708 scopus 로고    scopus 로고
    • NSAIDs-induced gastrointestinal damage. Review
    • Arroyo M, Lanas A. NSAIDs-induced gastrointestinal damage. Review. Minerva Gastroenterol Dietol 2006;52:249-59
    • (2006) Minerva Gastroenterol Dietol , vol.52 , pp. 249-259
    • Arroyo, M.1    Lanas, A.2
  • 13
    • 33747887675 scopus 로고    scopus 로고
    • Selective Serotonin Reuptake Inhibitors and Risk of Upper GI Bleeding: Confusion or Confounding?
    • DOI 10.1016/j.amjmed.2005.11.006, PII S0002934305010648
    • Yuan Y, Tsoi K, Hunt RH. Selective serotonin reuptake inhibitors and risk of upper GI bleeding: confusion or confounding? Am J Med 2006;119:719-27 (Pubitemid 44291626)
    • (2006) American Journal of Medicine , vol.119 , Issue.9 , pp. 719-727
    • Yuan, Y.1    Tsoi, K.2    Hunt, R.H.3
  • 14
    • 33748099549 scopus 로고    scopus 로고
    • Interaction between selective serotonin reuptake inhibitors and nonsteroidal antiinflammatory drugs: Review of the literature
    • Mort JR, Aparasu RR, Baer RK. Interaction between selective serotonin reuptake inhibitors and nonsteroidal antiinflammatory drugs: review of the literature. Pharmacotherapy 2006;26:1307-13
    • (2006) Pharmacotherapy , vol.26 , pp. 1307-1313
    • Mort, J.R.1    Aparasu, R.R.2    Baer, R.K.3
  • 15
    • 33846803757 scopus 로고    scopus 로고
    • Low-dose aspirin and upper gastrointestinal damage: Epidemiology, prevention and treatment
    • DOI 10.1185/030079907X162656
    • Lanas A, Scheiman J. Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment. Curr Med Res Opin 2007;23:163-73 (Pubitemid 46201599)
    • (2007) Current Medical Research and Opinion , vol.23 , Issue.1 , pp. 163-173
    • Lanas, A.1    Scheiman, J.2
  • 16
    • 33749536913 scopus 로고    scopus 로고
    • Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications
    • DOI 10.1186/1741-7015-4-22
    • Hernandez-Diaz S, Garcia-Rodriguez LA. Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications. BMC Med 2006;4:22 (Pubitemid 44524375)
    • (2006) BMC Medicine , vol.4 , pp. 22
    • Hernandez-Diaz, S.1    Garcia Rodriguez, L.A.2
  • 20
    • 68149112374 scopus 로고    scopus 로고
    • The preventive factors for aspirin-induced peptic ulcer: Aspirin ulcer and corpus atrophy
    • Shiotani A, Sakakibara T, Yamanaka Y, et al. The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy. J Gastroenterol 2009;44:717-25
    • (2009) J Gastroenterol , vol.44 , pp. 717-725
    • Shiotani, A.1    Sakakibara, T.2    Yamanaka, Y.3
  • 21
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee.
    • CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-39
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 23
    • 53149116673 scopus 로고    scopus 로고
    • Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin
    • Yeomans N, Lanas A, Labenz J, et al. Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin. Am J Gastroenterol 2008;103:2465-73
    • (2008) Am J Gastroenterol , vol.103 , pp. 2465-2473
    • Yeomans, N.1    Lanas, A.2    Labenz, J.3
  • 24
    • 72249102783 scopus 로고    scopus 로고
    • Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions
    • Ng FH, Wong SY, Lam KF, et al. Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions. Gastronterology 2010;138:82-8
    • Gastronterology , vol.2010 , Issue.138 , pp. 82-88
    • Ng, F.H.1    Wong, S.Y.2    Lam, K.F.3
  • 25
    • 0034699601 scopus 로고    scopus 로고
    • Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding
    • Lanas A, Bajador E, Serrano P, et al. Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med 2000;343:834-39
    • (2000) N Engl J Med , vol.343 , pp. 834-839
    • Lanas, A.1    Bajador, E.2    Serrano, P.3
  • 28
    • 4544327298 scopus 로고    scopus 로고
    • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction - executive summary
    • Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction - executive summary. J Am Coll Cardiol 2004;44:671-19
    • (2004) J Am Coll Cardiol , vol.44 , pp. 671-619
    • Antman, E.M.1    Anbe, D.T.2    Armstrong, P.W.3
  • 29
    • 0036788546 scopus 로고    scopus 로고
    • ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction - 2002: Summary article: A report of the American College of Cardiology/American Heart Association task force on practice guidelines
    • Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction - 2002: summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation 2002;106:1893-900
    • (2002) Circulation , vol.106 , pp. 1893-1900
    • Braunwald, E.1    Antman, E.M.2    Beasley, J.W.3
  • 30
    • 34547772153 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: The task force for the diagnosis and treatment of non-st-segment elevation acute coronary syndromes of the European Society of Cardiology
    • Task Force Members. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: the task force for the diagnosis and treatment of non-st-segment elevation acute coronary syndromes of the European Society of Cardiology. Eur Heart J 2007;28:1598-660
    • (2007) Eur Heart J , vol.28 , pp. 1598-1660
    • Task Force, Members.1
  • 31
    • 57349189353 scopus 로고    scopus 로고
    • Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation
    • Task Force Members.
    • Task Force Members. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation. Eur Heart J 2008;29:2909-45
    • (2008) Eur Heart J , vol.29 , pp. 2909-2945
  • 32
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • DOI 10.1161/CIRCULATIONAHA.106.612812, PII 0000301720060822000007
    • Eikelboom JW, Mehta SR, Anand SS, et al. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 2006;114:774-82 (Pubitemid 44268228)
    • (2006) Circulation , vol.114 , Issue.8 , pp. 774-782
    • Eikelboom, J.W.1    Mehta, S.R.2    Anand, S.S.3    Xie, C.4    Fox, K.A.A.5    Yusuf, S.6
  • 34
    • 58749093909 scopus 로고    scopus 로고
    • Bleeding risk associated with 1 year of dual antiplatelet therapy after percutaneous coronary intervention: Insights from the Clopidogrel for the Reduction of Events during Observation (CREDO) trial
    • CREDO Investigators
    • Aronow HD, Steinhubl SR, Brennan DM, et al.; CREDO Investigators. Bleeding risk associated with 1 year of dual antiplatelet therapy after percutaneous coronary intervention: insights from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial. Am Heart J 2009;157:369-74
    • (2009) Am Heart J , vol.157 , pp. 369-374
    • Aronow, H.D.1    Steinhubl, S.R.2    Brennan, D.M.3
  • 35
    • 54049118496 scopus 로고    scopus 로고
    • ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the
    • American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents
    • Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol 2008;52:1502-17
    • J Am Coll Cardiol , vol.2008 , Issue.52 , pp. 1502-1517
    • Bhatt, D.L.1    Scheiman, J.2    Abraham, N.S.3
  • 36
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • Gilard M, Arnaud B, Cornily JC, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol 2008;51:256-60
    • (2008) J Am Coll Cardiol , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3
  • 37
    • 61549124132 scopus 로고    scopus 로고
    • Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome
    • Ho PM, Maddox TM, Wang L, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA 2009;301:937-44
    • (2009) JAMA , vol.301 , pp. 937-44
    • Ho, P.M.1    Maddox, T.M.2    Wang, L.3
  • 40
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton pump inhibitor: An analysis of two randomised trials
    • ODonoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton pump inhibitor: an analysis of two randomised trials. Lancet 2009;374:989-97
    • (2009) Lancet , vol.374 , pp. 989-997
    • Odonoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 41
    • 84876992830 scopus 로고    scopus 로고
    • [Last accessed 26 March 2010]
    • Bhatt D, Cryer B, Contant C, et al. The cogent trial. Available from: www.cardiosource.com/clinicaltrials/trial. asp?trialID=1872. [Last accessed 26 March 2010]
    • The Cogent Trial
    • Bhatt, D.1    Cryer, B.2    Contant, C.3
  • 42
    • 71449119996 scopus 로고    scopus 로고
    • Predictors of gastroduodenal erosions in patients taking low-dose aspirin
    • Hart J, Hawkey CJ, Lanas A, et al. Predictors of gastroduodenal erosions in patients taking low-dose aspirin. Aliment Pharmacol Ther 2010;31:143-9
    • Aliment Pharmacol Ther , vol.2010 , Issue.31 , pp. 143-149
    • Hart, J.1    Hawkey, C.J.2    Lanas, A.3
  • 44
    • 34147093105 scopus 로고    scopus 로고
    • Ascorbic acid attenuates aspirin-induced gastric damage: Role of inducible nitric oxide synthase
    • Konturek PC, Kania J, Hahn EG. Konturek JW. Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase. J Physiol Pharmacol 2006;57(Suppl 5):125-36 (Pubitemid 46569789)
    • (2006) Journal of Physiology and Pharmacology , vol.57 , Issue.SUPPL. 5 , pp. 125-136
    • Konturek, P.C.1    Kania, J.2    Hahn, E.G.3    Konturek, J.W.4
  • 45
    • 0033825743 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs
    • Tseng CC, Wolfe MM. Nonsteroidal anti-inflammatory drugs. Med Clin North Am 2000;84:1329-44
    • (2000) Med Clin North Am , vol.84 , pp. 1329-1344
    • Tseng, C.C.1    Wolfe, M.M.2
  • 46
    • 32644444957 scopus 로고    scopus 로고
    • A multi-country economic evaluation of low-dose aspirin in the primary prevention of cardiovascular disease
    • DOI 10.2165/00019053-200624020-00005
    • Lamotte M, Annemans L, Evers T, Kubin M. A multi-country economic evaluation of low-dose aspirin in the primary prevention of cardiovascular disease. Pharmacoeconomics 2006;24:155-69 (Pubitemid 43242197)
    • (2006) PharmacoEconomics , vol.24 , Issue.2 , pp. 155-169
    • Lamotte, M.1    Annemans, L.2    Evers, T.3    Kubin, M.4
  • 47
    • 72249105864 scopus 로고    scopus 로고
    • A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding
    • Hsiao FY, Tsai YW, Huang WF, et al. A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding. Clin Ther 2009;31:2038-47
    • (2009) Clin Ther , vol.31 , pp. 2038-2047
    • Hsiao, F.Y.1    Tsai, Y.W.2    Huang, W.F.3
  • 48
    • 34248157118 scopus 로고    scopus 로고
    • Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
    • DOI 10.1016/S0140-6736(07)60747-8, PII S0140673607607478
    • Flossmann E, Rothwell PM.; British Doctors Aspirin Trial and the UK-TIA Aspirin Trial. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 2007;369:1603-13 (Pubitemid 46710123)
    • (2007) Lancet , vol.369 , Issue.9573 , pp. 1603-1613
    • Flossmann, E.1    Rothwell, P.M.2
  • 51
    • 37349129228 scopus 로고    scopus 로고
    • Aspirin and Folic Acid for the Prevention of Recurrent Colorectal Adenomas
    • DOI 10.1053/j.gastro.2007.10.014, PII S0016508507018136
    • Logan RF, Grainge MJ, Shepherd VC, et al. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology 2008;134:29-38 (Pubitemid 350309319)
    • (2008) Gastroenterology , vol.134 , Issue.1 , pp. 29-38
    • Logan, R.F.A.1    Grainge, M.J.2    Shepherd, V.C.3    Armitage, N.C.4    Muir, K.R.5
  • 54
    • 52649086351 scopus 로고    scopus 로고
    • Aspirin, nonsteroidal anti-inflammatory drugs, and the risks of cancers of the esophagus
    • Sadeghi SC, Bain CJ, Pandeya N, et al. Aspirin, nonsteroidal anti-inflammatory drugs, and the risks of cancers of the esophagus. Cancer Epidemiol Biomarkers Prev 2008;17:1169-78
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 1169-1168
    • Sadeghi, S.C.1    Bain, C.J.2    Pandeya, N.3
  • 56
    • 41349112480 scopus 로고    scopus 로고
    • NSAIDs, Risks, and Gastroprotective Strategies: Current Status and Future
    • DOI 10.1053/j.gastro.2008.02.007, PII S0016508508002412
    • Graham DY, Chan FK. NSAIDs, risks, and gastroprotective strategies: current status and future. Gastroenterology 2008;134:1240-6 (Pubitemid 351451996)
    • (2008) Gastroenterology , vol.134 , Issue.4 , pp. 1240-1246
    • Graham, D.Y.1    Chan, F.K.L.2
  • 57
    • 68849123400 scopus 로고    scopus 로고
    • Aspirin use and survival after diagnosis of colorectal cancer
    • Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA 2009;302:649-58
    • (2009) JAMA , vol.302 , pp. 649-658
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 58
    • 0038748968 scopus 로고    scopus 로고
    • World Health Organization [Last accessed 14 June 2010]
    • World Health Organization. Global cancer rates could increase by 50% to 15 million by 2020. Available from: http://www.who.int/mediacentre/news/ releases/2003/pr27/en/. [Last accessed 14 June 2010]
    • Global Cancer Rates Could Increase by 50% to 15 Million by 2020


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.