Famotidine Is Inferior to Pantoprazole in Preventing Recurrence of Aspirin-Related Peptic Ulcers or Erosions

Gastroenterology

Volumn 138, Issue 1, 2010, Pages 82-88

  Ng, Fook Hong ^a   Wong, Siu Yin ^b   Lam, Kwok Fai ^b   Chu, Wai Ming ^a   Chan, Pierre ^b   Ling, Yuk Hei ^a   Kng, Carolyn ^a   Yuen, Wai Cheung ^a   Lau, Yuk Kong ^a   Kwan, Ambrose ^a   Wong, Benjamin C Y ^b  

^a RUTTONJEE HOSPITAL   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; FAMOTIDINE; PANTOPRAZOLE; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE ESCALATION; DRUG EFFICACY; DYSPEPSIA; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; PEPTIC ULCER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; TREATMENT RESPONSE; ULCER PERFORATION;

EID: 72249102783     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.09.063     Document Type: Article

References (26)

1. Collaborative overview of randomised trials of antiplatelet therapy I. prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308 (1994) 81-106
2. UK-TIA Study Group. The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiatry 54 (1991) 1044-1054
3. Chan F.K.L., Chung S.C., Yuen B.Y., et al. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med 344 (2001) 967-973
4. Lai K.C., Lam S.K., Chu K.M., et al. Lansprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med 346 (2002) 2033-2038
5. Ng F.H., Wong S.Y., Chang C.M., et al. High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease. Aliment Pharmacol Ther 18 (2003) 443-449
6. Chan F.K.L., Ching J.Y.L., Hung L.C.T., et al. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 352 (2005) 238-244
7. Lai K.C., Chu K.M., Hui W.M., et al. Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications. Clin Gastroenterol Hepatol 4 (2006) 860-865
8. Bhatt D.L., Scheiman J., Abraham N.S., et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Am J Gastroenterol 103 (2008) 2890-2907
9. Taha A.S., Hudson N., Hawkey C.J., et al. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal anti-inflammatory drugs. N Engl J Med 334 (1996) 1435-1439
10. Hudson N., Haha A.S., Russell R.I., et al. Famotidine for healing and maintenance in nonsteroidal anti-inflammatory drug-associated gastroduodenal ulceration. Gastroenterology 112 (1997) 1817-1822
11. Rostom A., Dube C., Wells G., et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev 4 (2002) CD002296
12. Yin Q., Chow S.S., and Tomlinson B. Clinical bioequivalence study on two famotidine formulations (Famolta vs Pepcidine) (March 15, 2003), The Chinese University of Hong Kong, Hong Kong
13. Yeomans N.D., Tulassay Z., Juhász L., et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med 338 (1998) 719-726
14. Lwanga S.K., and Lemeshow S. Sample size determination in health studies (1991), World Health Organization, Geneva, Switzerland
15. Rao A.K., Pratt C., Berke A., et al. Thrombolysis in Myocardial Infarction (TIMI) Trial-phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. J Am Coll Cardiol 11 (1988) 1-11
16. Lanas A., Bajador E., Serrano P., et al. Nitrovasodilators, low-dose aspirin, other nonsteroidal anti-inflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med 343 (2000) 834-839
17. Lanas A., García Rodríguez L.A., Arroyo M.T., et al. Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants. Am J Gastroenterol 102 (2007) 507-515
18. Taha A.S., McCloskey C., Prasad R., et al. Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial. Lancet 374 (2009) 119-125
19. Laheij R.J., Van Rossum L.G., Jansen J.B., et al. Proton-pump inhibitor therapy for acetylsalicylic acid associated upper gastrointestinal symptoms: a randomized placebo-controlled trial. Aliment Pharmacol Ther 18 (2003) 109-115
20. Yeomans N., Lanas A., Labenz J., et al. Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin. Am J Gastroenterol 103 (2008) 2465-2473
21. Laheij R.J., van Rossum L.G., Jansen J.B., et al. Quality of life implications in patients with cardiovascular disease and dyspeptic symptoms. Gastroenterology 122 Suppl 1 (2002) 785
22. Pounder R. Silent peptic ulceration: deadly silence or golden silence?. Gastroenterology 96 (1989) 626-631
23. Hilton D., Iman N., Burke G.J., et al. Absence of abdominal pain in older persons with endoscopic ulcers: a prospective study. Am J Gastroenterol 96 (2001) 380-384
24. Famotidine: drug information. Up To Date website. http://www.uptodate.com/online/content/topic.do?topicKey=drug_a_K/102624 Accessed June 1, 2008
25. Hui W.M., Lam S.K., Ho J., et al. Effect of sucralfate and cimetidine on duodenal ulcer-associated antral gastritis and Campylobacter pylori. Am J Med 86 (1989) 60-65
26. Cappell M.S. The safety and clinical utility of esophagogastroduodenoscopy for acute gastrointestinal bleeding after myocardial infarction: a six-year study of 42 endoscopies in 34 consecutive patients at two university teaching hospitals. Am J Gastroenterol 88 (1993) 344-350