Off-label use of aromatase inhibitors to promote taller stature: Is it safe?

Hormone Research in Paediatrics

Volumn 74, Issue 6, 2010, Pages 436-437

  Dunkel, Leo ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANASTROZOLE; CYTOCHROME P450; ESTROGEN; LETROZOLE; TESTOLACTONE;

ADULT; BONE AGE; BONE MATURATION; CASE REPORT; DRUG SAFETY; GENE MUTATION; HUMAN; MALE; NOTE; OFF LABEL DRUG USE; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; TALL STATURE;

ADOLESCENT; AROMATASE INHIBITORS; BODY HEIGHT; GROWTH DISORDERS; HUMANS; MALE; NITRILES; OFF-LABEL USE; TRIAZOLES;

EID: 78650428789     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000317434     Document Type: Note

References (9)

1. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, et al: Estrogen resistance caused by a mutation in the estrogenreceptor gene in a man. N Engl J Med 1994;331:1056-1061.
2. Erratum in: N Engl J Med 1995;332:131.
3. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K: Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 1995;80:3689-3698.
4. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, et al: Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 1997;337:91-95.
5. Wickman S, Sipilä I, Ankarberg-Lindgren C, Norjavaara E, Dunkel L: A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial. Lancet 2001;357:1743-1748.
6. Hero M, Norjavaara E, Dunkel L: Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial. J Clin Endocrinol Metab 2005;90:6396-6402.
7. Mauras N, Gonzalez de Pijem L, Hsiang HY, Desrosiers P, Rapaport R, Schwartz ID, Klein KO, Singh RJ, Miyamoto A, Bishop K: Anastrozole increases predicted adult height of short adolescent males treated with growth hormone: a randomized, placebocontrolled, multicenter trial for one to three years. J Clin Endocrinol Metab 2008;93:823-831.
8. Salehpour S, Alipour P, Razzaghi-Azar M, Ardeshipour L, Shamshiri A, Monfared MF, Gharib A: A double-blind, placebo-controlled comparison of letrozole to oxandrolone effects upon growth and puberty of children with constitutional delay of puberty and idiopathic short stature. Horm Res 2010;74:428-435.
9. Hero M, Toiviainen-Salo S, Wickman S, Mäkitie O, Dunkel L: Vertebral morphology in aromatase inhibitor treated males with idiopathic short stature or constitutional delay of puberty. J Bone Miner Res 2010;25:1536-1543.