Vertebral morphology in aromatase inhibitor-treated males with idiopathic short stature or constitutional delay of puberty

Journal of Bone and Mineral Research

Volumn 25, Issue 7, 2010, Pages 1536-1543

  Hero, Matti ^a   Toiviainen Salo, Sanna ^b   Wickman, Sanna ^a   Mäkitie, Outi ^a   Dunkel, Leo ^c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Aromatase inhibitor; Bone; Estrogen; Osteoporosis; Vertebral compression

Indexed keywords

LETROZOLE; PLACEBO; TESTOSTERONE;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED PUBERTY; HUMAN; IDIOPATHIC DISEASE; INTERVERTEBRAL DISK; LOW DRUG DOSE; MALE; NERVE ENDING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREPUBERTY; PREVALENCE; PUBERTY; RANDOMIZED CONTROLLED TRIAL; SHORT STATURE; VERTEBRA; VERTEBRA BODY; VERTEBRA MALFORMATION;

ADOLESCENT; AROMATASE INHIBITORS; CHILD; GROWTH DISORDERS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NITRILES; PUBERTY; PUBERTY, DELAYED; SPINE; TESTOSTERONE; TRIAZOLES;

EID: 77954116468     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.56     Document Type: Article

References (25)

1. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab. 1995;80:3689-3698.
2. Carani C, Qin K, Simoni M, et al. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med. 1997;337:91-95.
3. Bilezikian JP, Morishima A, Bell J, Grumbach MM. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med. 1998;339:599-603.
4. Herrmann BL, Saller B, Janssen OE, et al. Impact of estrogen replacement therapy in a male with congenital aromatase deficiency caused by a novel mutation in the CYP19 gene. J Clin Endocrinol Metab. 2002;87:5476-5484.
5. Smith EP, Boyd J, Frank GR, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med. 1994;331:1056-1061.
6. Wickman S, Sipila I, Ankarberg-Lindgren C, Norjavaara E, Dunkel L. A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial. Lancet. 2001;357:1743-1748.
7. Hero M, Norjavaara E, Dunkel L. Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial. J Clin Endocrinol Metab. 2005;90:6396-6402. (Pubitemid 41759291)
8. Hero M, Wickman S, Dunkel L. May Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty. Clin Endocrinol (Oxf). 2006;64:510-513.
9. Mauras N, Gonzalez de Pijem L, Hsiang HY, et al. Anastrozole increases predicted adult height of short adolescent males treated with growth hormone: a randomized, placebo-controlled, multicenter trial for one to three years. J Clin Endocrinol Metab. 2008;93:823-831.
10. Hero M, Makitie O, Kroger H, Nousiainen E, Toiviainen-Salo S, Dunkel L. Impact of Aromatase Inhibitor Therapy on Bone Turnover, Cortical Bone Growth and Vertebral Morphology in Pre- and Peripubertal Boys with Idiopathic Short Stature. Horm Res. 2009;71:290-297.
11. Greulich WW, Pyle SI. Radiographic atlas of skeletal development of the hand and wrist 2nd ed vol 1st Stanford University Press, Stanford: 1959.
12. Bayley NPS. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr. 1952;40:423-441.
13. Makitie O, Doria AS, Henriques F, et al. Mar Radiographic vertebral morphology: a diagnostic tool in pediatric osteoporosis. J Pediatr. 2005;146:395-401.
14. Stadnik TW, Lee RR, Coen HL, Neirynck EC, Buisseret TS, Osteaux MJ. Annular tears and disk herniation: prevalence and contrast enhancement on MR images in the absence of low back pain or sciatica. Radiology. 1998;206:49-55.
15. Masharawi Y, Rothschild B, Peled N, Hershkovitz I. A simple radiological method for recogninizing osteoporotic thoracic vertebral compression fractures and distinguishing them from Scheuermann disease. Spine. 2009;34:1995-1999.
16. Caruso-Nicoletti M, Cassorla F, Skerda M, Ross JL, Loriaux DL, Cutler GB Jr. Short term, low dose estradiol accelerates ulnar growth in boys. J Clin Endocrinol Metab. 1985;61:896-898. (Pubitemid 16218487)
17. Weise M, De-Levi S, Barnes KM, Gafni RI, Abad V, Baron J. Effects of estrogen on growth plate senescence and epiphyseal fusion. Proc Natl Acad Sci U S A. 2001;98:6871-6876. (Pubitemid 32538309)
18. Eshet R, Maor G, Ben Ari T, Ben Eliezer M, Gat-Yablonski G, Phillip M. The aromatase inhibitor letrozole increases epiphyseal growth plate height and tibial length in peripubertal male mice. J Endocrinol. 2004;182:165-172. (Pubitemid 39076912)
19. Ascani E, La Rosa G, Ascani C., Scheuermann kyphosis. In: Weinstein S, (ed) The Pediatric Spine: Principles and Practise 2nd edition ed, Lippincott, Williams & Wilkins, Philadelphia, USA, pp. 2001; 413-431.
20. Mauras N, O'Brien KO, Klein KO, Hayes V. Estrogen suppression in males metabolic effects. J Clin Endocrinol Metab. 2000;85:2370-2377. (Pubitemid 32269188)
21. Nakhla M, Scuccimarri R, Duffy KN, et al. Prevalence of Vertebral Fractures in Children with Chronic Rheumatic Diseases at Risk for Osteopenia. J Pediatr. 2009;154:438-443.
22. Valta H, Lahdenne P, Jalanko H, Aalto K, Makitie O. Bone health and growth in glucocorticoid-treated patients with juvenile idiopathic arthritis. J Rheumatol. 2007;34:831-836.
23. Valta H, Jalanko H, Holmberg C, Helenius I, Makitie O. Impaired bone health in adolescents after liver transplantation. Am J Transplant. 2008;8:150-157.
24. Valta H, Makitie O, Ronnholm K, Jalanko H. Bone Health in Children and Adolescents after Renal Transplantation. J Bone Miner Res. 2009;24:1699-1708.
25. Niemelainen R, Battie MC, Gill K, Videman T. The prevalence and characteristics of thoracic magnetic resonance imaging findings in men. Spine. 2008;33:2552-2559.