Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue

Neurochemistry International

Volumn 58, Issue 1, 2011, Pages 9-13

  Schröder, Helmut ^a   Höllt, Volker ^a   Becker, Axel ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Binding assay; Brain; Cannabinoid receptor; COX 2 inhibitor; HEK 293 cells

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 AMINOBUTYRIC ACID; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR; CYCLIC AMP; CYCLOOXYGENASE 2 INHIBITOR; GLUTAMIC ACID; PARECOXIB; VALDECOXIB;

ANIMAL TISSUE; ARTICLE; BRAIN; CELL STRAIN HEK293; DRUG EFFECT; EX VIVO STUDY; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACIDS; ANIMALS; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CYCLIC AMP; CYCLOHEXANOLS; CYCLOOXYGENASE 2 INHIBITORS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEK293 CELLS; HUMANS; ISOXAZOLES; MALE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; SULFONAMIDES; TRANSFECTION;

RATTUS; RATTUS NORVEGICUS;

EID: 78650419539     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.10.018     Document Type: Article

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