Reduced expression of Mad2 and Bub1 proteins is associated with spontaneous miscarriages

Molecular Human Reproduction

Volumn 17, Issue 1, 2011, Pages 14-21

  Shi, Qiong ^a   Hu, Min ^a   Luo, Min ^a   Liu, Qiang ^a   Jiang, Fengbing ^a   Zhang, Yan ^a   Wang, Sujia ^a   Yan, Chen ^a   Weng, Yaguang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Bub1; Chromosomal abnormality; Mad2; siRNA; Spontaneous miscarriage

Indexed keywords

BUB1 RELATED PROTEIN; PROTEIN MAD2;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; EMBRYO DEVELOPMENT; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SPONTANEOUS ABORTION;

ABORTION, SPONTANEOUS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; KARYOTYPING; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TROPHOBLASTS;

EID: 78650413662     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gaq065     Document Type: Article

References (23)

1. Bartel DP, Chen C-Z. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 2004; 5:396-400.
2. Byrne J, Warburton D, Kline J, Blanc W, Stein Z. Morphology of early fetal death and their chromosomal characteristics. Teratology 1985;32:297-315.
3. Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 2000;101:635-645.
4. Fritz B, Hallermann C, Olert J, Fuchs B, Bruns M, Aslan M, Schmidt S, Coerdt W, Müntefering H, Rehder H et al. Cytogenetic analysis of culture failures by comparative genomic hybridization (CGH) revaluation of chromosome aberrations. Eur J Hum Genet 2001; 9:539-547.
5. Hassold T, Hall H, Hunt P. The origin of human aneuploidy: where we have been, where we are going. Hum Mol Genet 2007;16:R203-R208.
6. Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2001;2:280-291.
7. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004;5:522-531.
8. Hernando E, Orlow I, Liberal V, Nohales G, Benezra R, Cordon-Cardo C. Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer. Int J Cancer 2001;95:223-227.
9. Kanellopoulou C, Muljo SA, Kung AL, Ganesan S, Drapkin R, Jenuwein T, Livingston DM, Rajewsky K. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev 2005;19:489-501.
10. Leland S, Nagarajan P, Polyzos A, Thomas S, Samaan G, Donnell R Marchetti F, Venkatachalam S. Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice. PNAS 2009; 106:12776-12781.
11. Masuda A, Takahashi T. Chromosome instability in human lung cancer: possible underlying mechanism and potential consequences in the pathogenesis. Oncogene 2002;21:6884-6897.
12. Mineno J, Okamoto S, Ando T, Sato M, Chono H, Izu H, Takayama M, Asada K, Mirochnitchenko O, Inouye M et al. The expression profile of microRNAs in mouse embryos. Nucleic Acids Res 2006; 34:1765-1771.
13. Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K. Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS ONE 2007;11:1-9.
14. Perera D, Tilston V, Hopwood JA, Barchi M, Boot-Handford RP, Taylor SS. Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. Dev Cell 2007;11:566-579.
15. Qumsiyeh MB, Kim KR, Ahmed MN, Bradford W. Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi. Cytogent Cell Genet 2000;88:230-235.
16. Sharp-Baker H, Chen R-H. Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity. J Cell Biol 2001;153:1239-1249.
17. Shichiri M, Yoshinaga K, Hisatomi H, Sugihara K, Hirata Y. Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res 2002; 62:13-17.
18. Stefani G, Slack FJ. Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol 2008;9:219-230.
19. Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY et al. Human embryonic stem cells express a unique set of microRNAs. Dev Biol 2004;270:488-498.
20. Tang Z, Sun Y, Harley SE, Zou H, Yu H. Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. PNAS 2004;101:18012-18017.
21. Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U. Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error. Mutat Res 2000;651: 14-29.
22. Yu H. Regulation of APC-Cdc20 by the spindle checkpoint. Cell Biol 2002; 14:706-714.
23. Yu HT. Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Md2 template model. J Cell Biol 2006; 173:153-157.