Vitamin D3 suppresses immune reactions in atherosclerosis, affecting regulatory T cells and dendritic cell function

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 12, 2010, Pages 2317-2319

  Bobryshev, Yuri V ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

atherosclerosis; dendritic cells; Foxp3; regulatory T cells; vascular biology; vitamin D3

Indexed keywords

CALCITRIOL; COLECALCIFEROL; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TRANSFORMING GROWTH FACTOR BETA; ANTIINFLAMMATORY AGENT; AUTACOID;

ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; CD4+ CD25+ T LYMPHOCYTE; CELL MATURATION; DENDRITIC CELL; EDITORIAL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; AORTA DISEASE; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPH NODE; METABOLISM; MOUSE; NOTE; ORAL DRUG ADMINISTRATION; PATHOLOGY; SMALL INTESTINE; SPLEEN;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; AORTIC DISEASES; ATHEROSCLEROSIS; CALCITRIOL; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; INFLAMMATION MEDIATORS; INTESTINE, SMALL; LYMPH NODES; MICE; SPLEEN; T-LYMPHOCYTES, REGULATORY;

EID: 78650399825     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.217141     Document Type: Editorial

References (29)

1. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010;39:365-379.
2. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. Curr Opin Pharmacol. 2010;10: 482-496.
3. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080S-1086S.
4. Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab. 2010;95:471-478.
5. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503-511.
6. Zittermann A, Koerfer R. Vitamin D in the prevention and treatment of coronary heart disease. Curr Opin Clin Nutr Metab Care. 2008;11: 752-757.
7. Takeda M, Yamashita T, Sasaki N, Nakajima K, Kita T, Shinohara M, Ishida T, Hirata K. Oral administration of an active form vitamin D3 (calcitriol) decreases atherosclerosis in mice via inducing regulatory T cells and immature dendritic cells with tolerogenic functions. Arterioscler Thromb Vasc Biol. 2010;30:2495-2503.
8. Wan YY. Regulatory T cells: immune suppression and beyond. Cell Mol Immunol. 2010;7:204-210.
9. Sakaguchi S, Miyara M, Costantino CM, Hafler DA. Foxp3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010;10: 490-500.
10. Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol. 2010;11:7-13.
11. Langier S, Sade K, Kivity S. Regulatory T cells: the suppressor arm of the immune system. Autoimmun Rev. Epub ahead of print August 31, 2010.
12. Nilsson J, Wigren M, Shah PK. Regulatory T cells and the control of modified lipoprotein autoimmunity-driven atherosclerosis. Trends Cardiovasc Med. 2009;19:272-276.
13. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245-252.
14. nd ed. San Diego, CA: Academic Press; 2001.
15. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685-711.
16. Liu K, Nussenzweig MC. Development and homeostasis of dendritic cells. Eur J Immunol. 2010;40:2099-2102.
17. Bobryshev YV. Dendritic cells and their role in atherogenesis. Lab Invest. 2010;90:970-984.
18. Choi JH, Do Y, Cheong C, Koh H, Boscardin SB, Oh YS, Bozzacco L, Trumpfheller C, Park CG, Steinman RM. Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves. J Exp Med. 2009;206:497-505.
19. Cybulsky MI, Jongstra-Bilen J. Resident intimal dendritic cells and the initiation of atherosclerosis. Curr Opin Lipidol. 2010;21:397-403.
20. Yamazaki S, Steinman RM. Dendritic cells as controllers of antigen-specific Foxp3 + regulatory T cells. J Dermatol Sci. 2009;54:69-75.
21. Cobbold SP, Adams E, Nolan KF, Regateiro FS, Waldmann H. Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link. Immunol Rev. 2010;236:203-218.
22. Van Es T, Van Puijvelde GH, Foks AC, Habets KL, Bot I, Gilboa E, Van Berkel TJ, Kuiper J. Vaccination against Foxp3( + ) regulatory T cells aggravates atherosclerosis. Atherosclerosis. 2010;209:74-80.
23. Adorini L, Giarratana N, Penna G. Pharmacological induction of tolerogenic dendritic cells and regulatory T cells. Semin Immunol. 2004; 16:127-134.
24. 3: basic concepts. J Steroid Biochem Mol Biol. 2005;97:93-101.
25. Sigmundsdottir H, Butcher EC. Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat Immunol. 2008;9:981-987.
26. Bobryshev YV. Dendritic cells and their involvement in atherosclerosis. Curr Opin Lipidol. 2000;11:511-517.
27. Nilsson J, Hansson GK. Autoimmunity in atherosclerosis: a protective response losing control? J Intern Med. 2008;263:464-478.
28. Klingenberg R, Hansson GK. Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies. Eur Heart J. 2009;30: 2838-2844.
29. Wu-Wong JR. Potential for vitamin D receptor agonists in the treatment of cardiovascular disease. Br J Pharmacol. 2009;158:395-412.