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The isochroman was obtained in 22% yield showing that H2O has a direct impact on the reaction
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The same reaction catalyzed by Bi(OTf)3 was performed with an other dehydrating reagent such as MgSO4 (2 eq) in the light of the basicity of 4 Å MS (See: Hasegawa, M.; Ono, F.; Kanemasa, S. Molecular sieves 4 Å work to mediate the catalytic metal enolization of nucleophile precursors: application to catalyzed enantioselective Michael addition reactions. Tetrahedron Lett. 2008, 49, 5220). The isochroman was obtained in 22% yield showing that H2O has a direct impact on the reaction.
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