Association between angiotensin-converting enzyme insertion/deletion genetic polymorphism and hypertension in a sample of Lebanese patients

Genetic Testing and Molecular Biomarkers

Volumn 14, Issue 6, 2010, Pages 787-792

  Akra Ismail, Maya ^a   Makki, Rajaa Fakhoury ^a   Chmaisse, Hania Nakkash ^a   Kazma, Alia ^b   Zgheib, Nathalie Khoueiry ^b  

^a BEIRUT ARAB UNIVERSITY   (Lebanon)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DNA ISOLATION; FEMALE; GEL ELECTROPHORESIS; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERTENSION; LEBANON; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PREVALENCE; RISK FACTOR;

AGE FACTORS; AGED; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERTENSION; INDEL MUTATION; LEBANON; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; RISK;

EID: 78650387774     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2010.0096     Document Type: Article

References (46)

1. Abbud ZA, Wilson AC, Cosgrove NM, et al. (1998) Angiotensinconverting enzyme gene polymorphism in systemic hypertension. Am J Cardiol 81:244-246.
2. Adrogue HJ, Madias NE (2007) Sodium and potassium in the pathogenesis of hypertension. N Engl J Med 356:1966-1978.
3. Al-Eisa A, Haider MZ, Srivastva BS (2000) Angiotensinconverting enzyme gene insertion/deletion polymorphism and renal damage in childhood uropathies. Pediatr Int 42:348-353.
4. Al-Eisa A, Haider MZ, Srivastva BS (2001) Angiotensin converting enzyme gene insertion/deletion polymorphism in idiopathic nephrotic syndrome in Kuwaiti Arab children. Scand J Urol Nephrol 35:239-242.
5. Al-Gasham A, Ismail H, Dewaidar M, et al. (2009) Methylenetetrahydrofolate reductase and angiotensin-converting enzyme gene polymorphisms among Saudi population from Qassim region. Genet Test Mol Biomarkers 13:817-820.
6. Bayoumi RA, Simsek M, Yahya TM, et al. (2006) Insertiondeletion polymorphism in the angiotensin-converting enzyme (ACE) gene among Sudanese, Somalis, Emiratis, and Omanis. Hum Biol 78:103-108.
7. Bianchi G, Tripodi G, Casari G, et al. (1994) Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 91:3999-4003.
8. Bouba I, Makrydimas G, Kalaitzidis R, et al. (2003) Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia. Eur J Obstet Gynecol Reprod Biol 110:8-11.
9. Boulpaep EL (2003) Regulation of arterial pressure and cardiac output. In: Boron WF, Boulpaep EL (eds) Medical Physiology, 1st Edition. Saunders, Philadephia, pp 534-557.
10. Chiang FT, Chern TH, Lai ZP, et al. (1996) Age-and genderdependent association of the angiotensin-converting enzyme gene with essential hypertension in a Chinese population. J Hum Hypertens 10:823-826.
11. Companioni NO, Sautie CM, Leal L, et al. (2007) ACE I/D polymorphism study in a Cuban hypertensive population. Clin Chim Acta 378:112-116.
12. Das M, Pal S, Ghosh A (2008) Angiotensin converting enzyme gene polymorphism (insertion/deletion) and hypertension in adult Asian Indians: a population-based study from Calcutta, India. Hum Biol 80:303-312.
13. El-Sibai M, Platt DE, Haber M, et al. (2009) Geographical structure of the Y-chromosomal genetic landscape of the Levant: a coastal-inland contrast. Ann Hum Genet 73:568-581.
14. Fatini C, Gensini F, Sticchi E, et al. (2003) ACE DD genotype: an independent predisposition factor to venous thromboembolism. Eur J Clin Invest 33:642-647.
15. Frossard PM, Obineche EN, Elshahat YI, et al. (1997) Deletion polymorphism in the angiotensin-converting enzyme gene is not associated with hypertension in a Gulf Arab population. Clin Genet 51:211-213.
16. Gensini F, Padeletti L, Fatini C, et al. (2003) Angiotensinconverting enzyme and endothelial nitric oxide synthase polymorphisms in patients with atrial fibrillation. Pacing Clin Electrophysiol 26:295-298.
17. Gesang L, Liu G, Cen W, et al. (2002) Angiotensin-converting enzyme gene polymorphism and its association with essential hypertension in a Tibetan population. Hypertens Res 25: 481-485.
18. Gonzalez-Ordonez AJ, Fernandez Carreira JM, Medina Rodriguez JM, et al. (2000) Risk of venous thromboembolism associated with the insertion/deletion polymorphism in the angiotensin-converting enzyme gene. Blood Coagul Fibrinolysis 11:485-490.
19. Gunes HV, Ata N, Degirmenci I, et al. (2004) Frequency of angiotensin-converting enzyme gene polymorphism in Turkish hypertensive patients. Int J Clin Pract 58:838-843. (Pubitemid 39462205)
20. Higaki J, Baba S, Katsuya T, et al. (2000) Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: the Suita Study. Circulation 101:2060-2065.
21. Hoffman BB (2007) Therapy of hypertension. In: Brunton L, Lazo J, Parker K (eds) The Pharmacological Basis of Therapeutics. Mc Graw Hill, La Jolla, CA, pp 845-868.
22. Hubert C, Houot AM, Corvol P, et al. (1991) Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J Biol Chem 266:15377-15383.
23. Ismail M, Akhtar N, Nasir M, et al. (2004) Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and essential hypertension in young Pakistani patients. J Biochem Mol Biol 37:552-555.
24. Jackson A, Brown K, Langdown J, et al. (2000) Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism. Br J Haematol 111: 562-564.
25. Kainulainen K, Perola M, Terwilliger J, et al. (1999) Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension. Hypertension 33:844-849.
26. Kotchen TA (2009) Hypertensive vascular disease. In: Fauci AS, Braunwald E, Kasper DL, et al. (eds) Harrisons Principles of Internal Medicine. Available at www.access medicine.com/content.aspx?aID=2872428, accessed January 5, 2009.
27. Kunes J, Zicha J (2009) The interaction of genetic and environmental factors in the etiology of hypertension. Physiol Res 58:S33-S41.
28. La Valle CJ, Issack PS, Baitner A, et al. (2001) The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty. BMC Musculoskelet Disord 2:1.
29. Marchlinski F (2009) The tachyarrhythmias. In: Fauci AS, Braunwald E, Kasper DL, et al. (eds) Harrisons Principles of Internal Medicine. Available at www.accessmedicine.com/content.aspx?aID=2901807, accessed January 5, 2009.
30. Mastana S, Nunn J (1997) Angiotensin-converting enzyme deletion polymorphism is associated with hypertension in a Sikh population. Hum Hered 47:250-253.
31. Morshed M, Khan H, Akhteruzzaman S (2002) Association between angiotensin I-converting enzyme gene polymorphism and hypertension in selected individuals of the Bangladeshi population. J Biochem Mol Biol 35:251-254.
32. Philipp CS, Dilley A, Saidi P, et al. (1998) Deletion polymorphism in the angiotensin-converting enzyme gene as a thrombophilic risk factor after hip arthroplasty. Thromb Haemost 80: 869-873.
33. Popov V, Fomicheva E, Kovalev J, et al. (1996) Absence of association between the angiotensin-converting enzyme gene polymorphism and borderline hypertension in men of St Petersburg, Russia. J Hum Hypertens 10:557-559.
34. Ravn LS, Benn M, Nordestgaard BG, et al. (2008) Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population. Pharmacogen Genomics 18:525-533.
35. Rice GI, Foy CA, Grant PJ (1999) Angiotensin converting enzyme and angiotensin II type 1-receptor gene polymorphisms and risk of ischaemic heart disease. Cardiovasc Res 41: 746-753.
36. Rigat B, Hubert C, Henc-Gelas F, et al. (1990) An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343-1346.
37. Sabbagh AS, Otrock ZK, Mahfoud ZR, et al. (2007) Angiotensinconverting enzyme gene polymorphism and allele frequencies in the Lebanese population: prevalence and review of the literature. Mol Biol Rep 34:47-52.
38. Salem AH, Batzer MA (2009) High frequency of the D allele of the angiotensin-converting enzyme gene in Arabic populations. BMC Res Notes 2:99.
39. Schmidt S, van HI, Grobbee DE, et al. (1993) Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study. J Hypertens 11:345-348.
40. Staessen JA, Wang JG, Ginocchio G, et al. (1997) The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk. J Hypertens 15:1579-1592.
41. Stanković A, Zivkovic M, Alavantic D (2002) Angiotensin Iconverting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension. Scand J Clin Lab Invest 62:469-475.
42. Tohme RA, Jurjus AR, Estephan A (2005) The prevalence of hypertension and its association with other cardiovascular disease risk factors in a representative sample of the Lebanese population. J Hum Hypertens 19:861-868.
43. Vassilikioti S, Doumas M, Douma S, et al. (1996) Angiotensin converting enzyme gene polymorphism is not related to essential hypertension in a Greek population. Am J Hypertens 9:700-702.
44. Von Depka M, Czwalinna A, Wermes C, et al. (2003) The deletion polymorphism in the angiotensin-converting enzyme gene is a moderate risk factor for venous thromboembolism. Thromb Haemost 89:847-852.
45. Zalloua PA, Xue Y, Khalife J, et al. (2008) Y-chromosomal diversity in Lebanon is structured by recent historical events. Am J Hum Genet 82:873-882.
46. Zaman MM, Yoshiike N, Date C, et al. (2001) Angiotensin converting enzyme genetic polymorphism is not associated with hypertension in a cross-sectional sample of a Japanese population: the Shibata Study. J Hypertens 19:47-53.