Effects of siRNA-targeting BMP-2 on the abilities of migration and invasion of human liver cancer SMMC7721 cells and its mechanism

Cancer Gene Therapy

Volumn 18, Issue 1, 2011, Pages 20-25

  Wu, J B ^a,b   Fu, H Q ^a,b   Huang, L Z ^a,b   Liu, A W ^a,b   Zhang, J X ^a,b  

^a NANCHANG UNIVERSITY   (China)

^b Key Laboratory of Molecular Medicine   (China)

Author keywords

bone morphogenetic protein; invasion; liver cancer; migration; RNA interference

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; GELATINASE A; GELATINASE B; LIPOFECTAMINE; LIPOSOME; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; PROTEIN C JUN; SMALL INTERFERING RNA; SYNAPTOPHYSIN;

ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; GENE EXPRESSION; GENE SYNTHESIS; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; LIVER CANCER; METASTASIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CELL LINE, TUMOR; CELL MOVEMENT; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 78650308689     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2010.55     Document Type: Article

References (13)

1. Langenfeld EM, Langenfeld J. Bone morphogenetic protein-2 stimulates angiogenesis in developing tumors. Mol Cancer Res 2004; 2: 141-149.
2. Davies SR, Watkins G, Douglas-Jones A, Mansel RE, Jiang WG. Bone morphogenetic proteins 1 to 7 in human breast cancer, expression pattern and clinical/prognostic relevance. J Exp Ther Oncol 2008; 7: 327-338.
3. Tuschl T, Zamore PD, Lehman R, Bartel DP, Sharp PA. Targeted mRNA degradation by double-strand RNA in vitro. Genes & Dev 1999; 13: 3191-3197.
4. Langenfeld EM, Calvano SE, Abou-Nukta F, Lowry SF, Amenta P, Langenfeld J. The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 2003; 24: 1445-1454.
5. Busch C, Drews U, Eisele SR, Garbe C, Oppitz M. Noggin blocks invasive growth of murine B16-F1 melanoma cells in the optic cup of the chick embryo. Int J Cancer 2008; 122: 526-533.
6. Rothhammer T, Poser I, Soncin F, Bataille F, Moser M, Bosserhoff AK. Bone morphogenic proteins are over-expressed in malignant melanoma and promote cell invasion and migration. Cancer Res 2005; 65: 448-456.
7. Montesano R. Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth. Biochem Biophys Res Commun 2007; 353: 817-822.
8. Deng H, Makizumi R, Ravikumar TS, Dong H, Yang W, Yang W. Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells. Exp Cell Res 2007; 313: 1033-1044.
9. Langenfeld EM, Bojnowski J, Perone J, Langenfeld J. Expression of bone morphogenetic proteins in human lung carcinomas. Ann Thorac Surg 2005; 80: 1028-1032.
10. Darby S, Cross SS, Brown NJ, Hamdy FC, Robson CN. BMP-6 over-expression in prostate cancer is associated with increased Id-1 protein and a more invasive phenotype. J Pathol 2008; 214: 394-404.
11. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006; 444: 761-765.
12. Busch C, Drews U, Eisele SR, Garbe C, Oppitz M. Noggin blocks invasive growth of murine B16-F1 melanoma cells in the optic cup of the chick embryo. Int J Cancer 2008; 122: 526-533.
13. Jian-bing W, Hua-qun F, Long-zhang H, An-wen L, Ji-xiang Z. Expression of bone morphogenetic protein 2 and 6 and clinical significance in liver carcinoma. World Chinese J Digestol 2009; 17: 834-837.