Automated synthesis of 18F analogue of paclitaxel (PAC): [18F]Paclitaxel (FPAC)

Applied Radiation and Isotopes

Volumn 65, Issue 6, 2007, Pages 696-700

  Kalen, Joseph D ^a   Hirsch, Jerry I ^a   Kurdziel, Karen A ^a   Eckelman, William C ^b   Kiesewetter, Dale O ^c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Molecular Tracer LLC   (United States)

^c NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

18F Paclitaxel; Automated synthesis system; Fluorine 18; Multidrug resistance; PET

Indexed keywords

AUTOMATED SYNTHESIS SYSTEM; FLUORINE-18; MULTIDRUG RESISTANCE;

CHEMOTHERAPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PATIENT TREATMENT; POSITRON EMISSION TOMOGRAPHY; PURIFICATION; TUMORS;

DRUG PRODUCTS;

FLUORINE 18; PACLITAXEL; PACLITAXEL F18; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE; RADIOPHARMACEUTICAL AGENT;

ARTICLE; CANCER CHEMOTHERAPY; DRUG PURIFICATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MULTIDRUG RESISTANCE; POSITRON; PRIORITY JOURNAL; QUALITY CONTROL; RADIOCHEMISTRY; AUTOMATION; CHEMISTRY; DRUG RESISTANCE; HUMAN; INSTRUMENTATION; NEOPLASM; SCINTISCANNING; STANDARD; SYNTHESIS;

AUTOMATION; DRUG RESISTANCE, NEOPLASM; FLUORINE RADIOISOTOPES; HUMANS; NEOPLASMS; PACLITAXEL; QUALITY CONTROL; RADIOCHEMISTRY; RADIOPHARMACEUTICALS;

EID: 34047265021     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2006.10.015     Document Type: Article

References (16)

1. Ambudkar S.V., Dey S., Hrycyna C.A., Ramachandra M., Pastan I., and Gottesman M.M. Biochemical, cellular, and pharmacological aspects of multidrug transporter. Annu. Rev. Pharamacol. Toxicol. 39 (1999) 361-398
2. Ambudkar S.V., Kim I.W., and Sauna Z.E. The power of the pump: mechanisms of action of P-glycoprotein (ABCB1). Eur. J. Pharm. Sci. 27 5 (2006) 392-400
3. Borst P., Evers R., Kool M., and Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst. 92 16 (2000) 1295-1302
4. FDA, 2003. U.S. Food and Drug Administration: International Conference on Harmonization (ICH) Guidance; Guide for Industry: @ -Tables and Literature 11-12-03.
5. FDA, 2005. Draft Guidance PET Drug Products-Current Good Manufacturing Practice (CGMP), U.S. Food and Drug Administration, September 2005.
6. Gottesman M.M., and Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62 (1993) 385-427
7. Kiesewetter D.O., Jagoda E.M., Kao C.H., Ma Y., Ravasi Y.L., Shimoji K., Szajek L.P., and Eckelman W.C. Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation. Nucl. Med. Biol. 30 1 (2003) 11-24
8. 18F-Paclitaxel in nonhuman primates. J. Nucl. Med. 44 8 (2003) 1330-1339
9. Lan L.B., Ayesh S., Lyubimov E., Pashinsky I., and Stein W.D. Kinetic parameters for reversal of the multidrug pump as measured for drug accumulation and cell killing. Cancer Chemother. Pharmacol. 38 2 (1996) 181-190
10. 18F]FDG preparations. Nucl. Med. Biol. 24 2 (1997) 193-195
11. Moins N., Cayre A., Chevillard S., Maublant J., Verrelle P., and Finat-Duclos F. Effects of MDR reversing agent combinations on the H-3-daunomycin accumulation in drug-sensitive and drug-resistant human cancer cells. Anticancer Res. 20 4 (2000) 2617-2623
12. Plumb J.A., Wishart G.C., Setanoians A., Morrison J.G., Hamilton T., Bicknell S.R., and Kaye S.B. Identification of a multidrugresistance modulator with clinical potential by analysis of synergistic activity in-vitro, toxicity in-vivo and growth delay in a solid human tumor xenograft. Biochem. Pharmacol. 47 2 (1994) 257-266
13. 18F reaction. Radiochim. Acta 26 (1979) 21
14. Sharma V. Radiopharmaceuticals for assessment of multidrug resistance P-glycoprotein-mediated drug transport activity. Bioconjugate Chem. 15 6 (2004) 1464-1474
15. Tan B., Piwnica-Worms D., and Ratner L. Multidrug resistance transporters and modulation. Curr. Opin. Oncol. 12 5 (2000) 450-458
16. Thiebaut F., Tsuruo T., Hamada H., Gottesman M.M., Pastan I., and Willingham M.C. Cellular-localization of the multidrug-resistance gene-product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. 84 21 (1987) 7735-7738