The complexity of human leukocyte antigen (HLA)-DQ antibodies and its effect on virtual crossmatching

Transplantation

Volumn 90, Issue 10, 2010, Pages 1117-1124

  Tambur, Anat R ^a   Leventhal, Joseph R ^b   Friedewald, John J ^a   Ramon, Daniel S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

HLA antibodies; HLA DQ ; Virtual crossmatch

Indexed keywords

ANTIBODY; HLA ANTIGEN CLASS 2; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HUMAN LEUKOCYTE ANTIGEN DQ ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; BETA CHAIN; BLOOD GROUP TYPING; HUMAN; HYBRIDIZATION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; AGED; ALLELES; AUTOANTIBODIES; AUTOANTIGENS; EPITOPES; FEMALE; HISTOCOMPATIBILITY TESTING; HLA-DQ ANTIGENS; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MODELS, MOLECULAR; USER-COMPUTER INTERFACE; YOUNG ADULT;

EID: 78650295833     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181f89c6d     Document Type: Article

References (34)

1. Ho EK, Vlad G, Colovai AI, et al. Alloantibodies in heart transplantation. Hum Immunol 2009;70:825.
2. Campos EF, Tedesco-Silva H, Machado PG, et al. Post-transplant anti-HLA class II antibodies as risk factor for late kidney allograft failure. Am J Transplant 2006;6:2316.
3. Cosio FG, Gloor JM, Sethi S, et al. Transplant glomerulopathy. Am J Transplant 2008;8:492.
4. Duquesnoy RJ. Human leukocyte antigen class II antibodies and transplant outcome. Transplantation 2008;86:638.
5. Duquesnoy RJ, Awadalla Y, Lomago J, et al. Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR, DQ, DP epitopes. Transpl Immunol 2008;18:352.
6. Girnita AL, McCurry KR, Iacono AT, et al. HLA-specific antibodies are associated with high-grade and persistent-recurrent lung allograft acute rejection. J Heart Lung Transplant 2004;23:1135.
7. Pollinger HS, Stegall MD, Gloor JM, et al. Kidney transplantation in patients with antibodies against donor HLA class II. Am J Transplant 2007;7:857.
8. Tambur AR, Bray RA, Takemoto SK, et al. Flow cytometric detection of HLA-specific antibodies as a predictor of heart allograft rejection. Transplantation 2000;70:1055.
9. Mach B. Genetics of histocompatibility. Curr Opin Hematol 1994;1:4.
10. Anthony Nolan Research Institute. IMGT/HLA Sequence Database. Available at: http://www.anthonynolan.org.uk/HIG/data.html. Accessed January 31, 2010.
11. Fernandez-Vina MA, Gao XJ, Moraes ME, et al. Alleles at four HLA class II loci determined by oligonucleotide hybridization and their associations in five ethnic groups. Immunogenetics 1991;34:299.
12. Pei R, Lee J, Chen T, et al. Flow cytometric detection of HLA antibodies using a spectrum of microbeads. Hum Immunol 1999;60:1293.
13. Pei R, Lee JH, Shih NJ, et al. Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 2003;75:43.
14. Pei R, Wang G, Tarsitani C, et al. Simultaneous HLA class I and class II antibodies screening with flow cytometry. Hum Immunol 1998;59:313.
15. Barabanova Y, Ramon DS, Tambur AR. Antibodies against HLA-DQ alpha-chain and their role in organ transplantation. Hum Immunol 2009;70:410.
16. Tambur AR, Ramon DS, Kaufman DB, et al. Perception versus reality? Virtual crossmatch-How to overcome some of the technical and logistic limitations. Am J Transplant 2009;9:1886.
17. Klitz W, Maiers M, Spellman S, et al. New HLA haplotype frequency reference standards: High-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans. Tissue Antigens 2003;62:296.
18. Tambur AR, Leventhal J, Kaufman DB, et al. Tailoring antibody testing and how to use it in the calculated panel reactive antibody era: The Northwestern University experience. Transplantation 2008;86:1052.
19. Zachary AA, Montgomery RA, Leffell MS. Defining unacceptable HLA antigens. Curr Opin Organ Transplant 2008;13:405.
20. Zachary AA, Leffell MS. Detecting and monitoring human leukocyte antigen-specific antibodies. Hum Immunol 2008;69:591.
21. Brown JH, Jardetzky TS, Gorga JC, et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993;364:33.
22. Bjorkman PJ, Saper MA, Samraoui B, et al. Structure ofthe human class I histocompatibility antigen, HLA-A2. Nature 1987;329:506.
23. Duquesnoy RJ, Askar M. HLAMatchmaker: A molecularly based algorithm for histocompatibility determination. V. Eplet matching for HLA-DR, HLA-DQ, and HLA-DP. Hum Immunol 2007;68:12.
24. Duquesnoy RJ, Marrari M. HLAMatchmaker-based definition of structural human leukocyte antigen epitopes detected by alloantibod-ies. Curr Opin Organ Transplant 2009;14:403.
25. El-Awar N, Cook D, Terasaki PI. HLA class Iepitopes: A and Bloci. Clin Transpl 2006:79.
26. Akaza T, El-Awar N, Nguyen A, et al. HLA class I epitopes: C-locus. Clin Transpl 2006:95.
27. Deng CT, Cai J, Tarsitani C, et al. HLA class II DQ epitopes. Clin Transpl 2006:115.
28. Deng CT, Cai J, Ozawa M, et al. HLA class II DP epitopes. Clin Transpl 2007:195.
29. Deng CT, El-Awar N, Ozawa M, et al. Human leukocyte antigen class II DQ alpha and beta epitopes identified from sera of kidney allograft recipients. Transplantation 2008;86:452.
30. Stroynowski I, Clark S, Henderson LA, et al. Interaction of alpha 1 with alpha 2 region in class I MHC proteins contributes determinants recognized by antibodies and cytotoxic T cells. J Immunol 1985;135:2160.
31. Germain RN, Ashwell JD, Lechler RI, et al. "Exon-shuffling" maps control of antibody-and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. Proc Natl Acad Sci USA 1985;82:2940.
32. Koeller D, Lieberman R, Miyazaki J, et al. Introduction of H-2Dd determinants into the H-2Ld antigen by site-directed mutagenesis. J Exp Med 1987;166:744.
33. HLA matchmaker. Available at: http://www.HLAMatchmaker.net. Accessed April 1, 2010.
34. NCBI Entrez structure. Available at: http://www.ncbi.nlm.nih.gov/ Structure/CN3D/cn3d.shtml. Accessed May 5, 2010.