Human leukocyte antigen class II DQ alpha and beta epitopes identified from sera of kidney allograft recipients

Transplantation

Volumn 86, Issue 3, 2008, Pages 452-459

  Deng, Chun Tsan ^a,c   El Awar, Nadim ^a   Ozawa, Miyuki ^a   Cai, Junchao ^b   Lachmann, Nils ^b   Terasaki, Paul I ^b  

^a One Lambda Inc   (United States)

^b TERASAKI FOUNDATION LABORATORY   (United States)

^c NONE   (United States)

Author keywords

DQ antibodies; HLA class II antigens; HLA DQ epitopes

Indexed keywords

EPITOPE; HLA ANTIBODY; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; MONOCLONAL ANTIBODY; ALLOANTIBODY; HLA DQ ANTIGEN;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; B LYMPHOBLAST; CONTROLLED STUDY; ELUTION; GRAFT RECIPIENT; HUMAN; HUMAN CELL; IMMUNOADSORPTION; IMMUNOGENICITY; KIDNEY ALLOGRAFT; KIDNEY TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ALLOTRANSPLANTATION; ANIMAL; ANTIBODY SPECIFICITY; B LYMPHOCYTE; BLOOD; CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; GRAFT REJECTION; HISTOCOMPATIBILITY TEST; IMMUNOLOGY; TIME;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; B-LYMPHOCYTES; CELL LINE; EPITOPE MAPPING; GRAFT REJECTION; HISTOCOMPATIBILITY TESTING; HLA-DQ ANTIGENS; HUMANS; IMMUNOSORBENT TECHNIQUES; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MICE; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 50549104856     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181804cd2     Document Type: Article

References (27)

1. El-Awar N, Lee JH, Tarsitani C, et al. HLA class I epitopes: Recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens. Hum Immunol 2007; 68: 170.
2. El-Awar N, Akaza T, Terasaki PI, et al. Human Leukicyte Antigen class I epitopes: Update to 103 total epitopes, including the C locus. Transplantation 2007; 84: 532.
3. El-AwarN, CookD,Terasaki PI. HLA class I epitopes:A and B Loci. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 79.
4. Akaza T, El-AwarN, HguyenA,etal. HLA classIepitopes: C-Locus. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 95.
5. Cai J, Terasaki PI, Mao Q, et al. Development of nondonor-specific HLA-DR antibodies in allograft recipients is associated with shared epitopes with mismatched donor DR antigens. Am J Transplant 2006; 6: 2947.
6. Cai J, Kohanof S, Terasaki PI. HLA-DR antibody epitopes. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 103.
7. Lee J-H, Lias M, Deng C-T, et al. A one-step monoclonal antibody typing procedure that simplifies HLA class I and class II typing. Tissue Antigens 1994; 44: 34.
8. Anthony Nolan Research Institute: IMGT/HLA Sequence Database. Available at: http://www.anthonynolan.org.uk/HIG/data.html.
9. NCBI Entrez structure website. Available at: http://www.ncbi.nlm.nih. gov/Structure/CN3D/cn3d.shtml.
10. Ozawa M, Rebellato LM, Terasaki PI, et al. Longitudinal testing of 266 renal allograft patients for HLA and MICA antibodies: Greenville experience. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 265.
11. KinukawaT,Kato M,Terasaki PI, et al. Retrospective antibody analysis of thirty patients with kidney graft failure. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 291.
12. Van den Berg-Loonen EM, Terasaki PI, Kohanof S, et al. Longitudianl testingof seventy-six renal allograft patients for HLA antibodies: Maastricht experience. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 305.
13. Piazza A, Poggi E, Ozzella G, et al. Post-transplant donor-specific antibody production and graft outcome in kidney transplantation: Results of sixteen-year monitoring by flow cytometry. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 323.
14. Lachmann N, Terasaki PI, Schönemann C. Donor-specific HLA antibodies in chronic renal allograft rejection: A prospective trial with a four-year follow-up. In: Terasaki PI, ed. Clinical transplantation l 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 171.
15. Rebellato LM, Ozawa M, Verbanac KM, et al. Clinical and anti-HLA antibody profile of nine renal transplant recipients with failed grafts: Donor-specific and nondonor-specific antibody development. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 241.
16. Mizutani K, Shibata L, Ozawa M, et al. Detection of HLA and MICA antibodies before kidney graft failure. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 255.
17. Worthington JE, Martin S, Barker AJ, et al. The role of HLA-specific antibodies in kidney transplant rejection: Published studies and local data. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006, pp 349.
18. Wade E, Goral S, Kearns J, et al. Experience with antibody-Mediated rejection in kidney allograft recipients. In: Terasaki PI, ed. Clinical transplantation 2006. Los Angeles, CA, Terasaki Foundation Laboratory 2006: pp 439.
19. Hourmant M, Cesbron-Gautier A, Terasaki PI, et al. Frequency and clinical implications of development of donor-specific and nondonor-specific HLA antibodies after kidney transplantation. J Am Soc Nephrol 2005; 16: 2804.
20. Mizutani K, Terasaki PI, Rosen A, et al. Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure.Am J Transplant 2005; 5: 2265.
21. Terasaki PI, Ozawa M. Predicting kidney graft failure by HLA antibodies: A prospective trial. Am J Transplant 2004; 4: 438.
22. Worthington JE, Martin S, Al-Husseini DM, el al. Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome. Transplantation 2003; 75: 1034.
23. Piazza A, Poggi E, Ozzella G, et al. Public epitope specificity of HLA class I antibodies induced by a failed kidney transplant: Alloantibody characterization by flow cytometric techniques. Transplantation 2006; 81: 1298.
24. Igarashi M, Gebhard DH, Chen YX, etal. Identification with the monoclonal antibody 26.163ofadeterminant sharedbythe beta chainsofthe gene products of the HLA-DR, DQ, and DP loci. Hum Immunol 1986; 16: 347.
25. McMichael AJ, Parham P, Rust N, et al. A monoclonal antibody that recognizes an antigenic determinant shared by HLA A2 and B17. Hum Immunol 1980; 1: 121.
26. Parham P, McLean J. Characterization, evolution and molecular basis of a polymorphic antigenic determinant shared by HLA-A and B products. Hum Immunol 1980; 1: 131.
27. Viken HD, Thorsby E, Gaudernack G. Characterization and epitope mapping of four HLA class II reactive mouse mAbs using transfected L cells and human cells transfected with mutants of DQB1*0302. Tissue Antigens 1995; 45: 250.