The effects of flubendazole and its metabolites on the larval development of Haemonchus contortus (Nematoda: Trichostrongylidae): An in vitro study

Helminthologia

Volumn 47, Issue 4, 2010, Pages 269-272

  Bartikova H ^a   Skalova L ^a   Lamka, J ^a   Szotakova B ^a   Varady M ^b  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b PARASITOLOGICAL INSTITUTE   (Slovakia)

Author keywords

anthelmintic resistance; benzimidazoles; biotransformation; larval development test

Indexed keywords

HAEMONCHUS CONTORTUS; NEMATODA; TRICHOSTRONGYLIDAE;

EID: 78650295294     PISSN: 04406605     EISSN: None     Source Type: Journal    
DOI: 10.2478/s11687-010-0042-7     Document Type: Article

References (14)

1. Álvarez-Sánchez, M. A., Pérez-García, J., Cruzrojo, M. A., Rojo-Vázquez, F. A. (2005): Real time PCR for the diagnosis of benzimidazole resistance in trichostrongylids of sheep. Vet. Parasitol., 129: 291-298.
2. Coles, G., Bauer, C., Borgsteede, F. H. M., Geerts, S., Klei, T. R., Taylor, M. A., Waller, P. J. (1992): World Association for the Advancement of Veterinary Parasitology (W. A. A. V. P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol., 44: 35-44.
3. Cvilink, V., Kubíček, V., Nobilis, M., Křížová, V., Szotáková, B., Lamka, J., Várady, M., Kuběnová, M., Novotná, R., Gavelová, M., Skálová, L. (2008): Biotransformation of flubendazole and selected model xenobiotics in Haemonchus contortus. Vet. Parasitol., 151: 242-248.
4. Dayan, A. D. (2003): Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics. Acta Tropica, 86: 141-159.
5. Dobson, R. J., Griffiths, D. A., Donald, A. D., Waller, P. J. (1987): A genetic model describing the evolution of levamisole resistance in Trichostrongylus colubriformis, a nematode parasite of sheep. IMA J. Appl. Math., 4: 279-293.
6. Hubert, J., Kerboeuf, D. (1992): A microlarval development assay for the detection of anthelmintic resistance in sheep nematodes. Vet. Rec., 130: 442-446.
7. Křížová, V., Nobilis, M., Prušková, L., Chládek, J., Szotáková, B., Cvilink, V., Skálová, L., Lamka, J. (2009): Pharmacokinetics of flubendazole and its metabolites in lambs and adult sheep (Ovis aries). J. Vet. Pharmacol. Ther., 32: 606-612.
8. Meuldermans, W. E., Hurkmans, R. M., Lauwers, W. F., Heykants, J. J. (1976): The in vitro metabolism of mebendazole by pig, rat and dog liver fractions. Eur. J. Drug Metab. Pharmacokinet., 1: 35-40.
9. Moreno L., Alvarez L., Mottier L., Virkel G., Sanches Bruni S., Lanusse C. (2004): Integrated pharmacological assessment of flubendazole potencial for use in sheep: disposition kinetics, liver metabolism and parasite diffusion. J. Vet. Pharmacol. Ther., 27: 299-308.
10. Roos, M. H., Otsen, M., Hoekstra, R., Veenstra, J. G., Lenstra, J. A. (2004): Genetic analysis of inbreeding of two strains of the parasitic nematode Haemonchus contortus. Int. J. Parasitol., 34: 109-115.
11. van Wyk, J. A., Malan, F. S. (1988): Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa. Vet. Rec., 123: 226-228.
12. Várady, M., Bjørn, H., Nansen, P. (1996): In vitro characterization of anthelmintic susceptibility of field isolates of the pig nodular worm Oesophagostomum sp. susceptible or resistant to various anthelmintics. Int. J. Parasitol., 26: 733-740.
13. Várady, M., Čudeková, P., Čorba, J. (2007): In vitro detection of benzimidazole resistance in Haemonchus contortus: Egg hatch test versus larval development test. Vet. Parasitol. 149: 104-110.
14. Von Samson-himmelstjerna, G., Walsh, T. K., Donnan, A. A., Carriére, S., Jackson, F., Skuce, P. J., Rohn, K., Woltenholme, A. J. (2009): Molecular detection of benzimidazoleresistance in Haemonchus contortus using real-time PCR and pyrosequencing. Parasitology, 136: 349-358.