Spina bifida: A diagnostic dilemma in paleopathology

Clinical Anatomy

Volumn 24, Issue 1, 2011, Pages 19-33

  Kumar, A ^a   Tubbs, R Shane ^b  

^a UNIVERSITY OF ARKANSAS   (United States)

^b CHILDREN S HOSPITAL   (United States)

Author keywords

neural tube defects; paleopathology; spina bifida; spinal dysraphisms; vertebral defects

Indexed keywords

HUMAN; NEURAL TUBE DEFECT; NUCLEAR MAGNETIC RESONANCE IMAGING; PALEOPATHOLOGY; PRIORITY JOURNAL; REVIEW; SKELETON MALFORMATION; SPINA BIFIDA;

ABNORMALITIES, MULTIPLE; BONE AND BONES; DOCUMENTATION; FEMALE; FOSSILS; HUMANS; MALE; PALEOPATHOLOGY; SPINAL DYSRAPHISM; TERMINOLOGY AS TOPIC;

EID: 78650290528     PISSN: 08973806     EISSN: 10982353     Source Type: Journal    
DOI: 10.1002/ca.21058     Document Type: Review

References (179)

1. Albrecht TL, Scutter SD, Henneberg M,. 2007. Radiographic method to assess the prevalence of sacral spina bifida occulta. Clin Anat 20: 170-174. (Pubitemid 46254456)
2. Arts MP, de Jong TH,. 2004. Thoracic meningocele, meningomyelocele or myelocystocele? Diagnostic difficulties, consequent implications and treatment. Pediatr Neurosurg 40: 75-79.
3. Aufderheide AC, Rodríguez-Martín C,. 1998. The Cambridge Encyclopedia of Paleopathology. Cambridge: Cambridge University Press.
4. Avrahami E, Frishman E, Fridman Z, Azor M,. 1994. Spina bifida occulta of S1 is not an innocent finding. Spine 19: 12-15. (Pubitemid 24039174)
5. Baker BJ, Dupras TL, Tocheri MW,. 2005. The Osteology of Infants and Children. College Station: Texas A & M University Press. 178 p.
6. Banerjee T,. 1977. Nonhealing myelomeningocele in an adult. South Med J 70: 367-368. (Pubitemid 8082531)
7. Barkovich AJ,. 2005. Pediatric Neuroimaging. 4th Ed. Philadelphia: Lippincott, Williams and Wilkins. 976 p.
8. Barnes E,. 1994. Developmental Defects of the Axial Skeleton in Paleopathology. Colorado: University Press of Colorado. 360 p.
9. Beaudin AE, Stover PJ,. 2007. Folate-mediated one-carbon metabolism and neural tube defects: Balancing genome synthesis and gene expression. Birth Defects Res C Embryo Today 81: 183-203.
10. Bennett KA,. 1972. Lumbo-sacral malformations and spina bifida occulta in a group of proto-historic Modoc Indians. Am J Phys Anthropol 36: 435-439.
11. Bentley JF, Smith JR,. 1960. Developmental posterior enteric remnants and spinal malformations: The split notochord syndrome. Arch Dis Child 35: 76-86.
12. Blom HJ, Shaw GM, den Heijer M, Finnell RH,. 2006. Neural tube defects and folate: Case far from closed. Nat Rev Neurosci 7: 724-731. (Pubitemid 44267496)
13. Boone D, Parsons D, Lachmann SM, Sherwood T,. 1985. Spina bifida occulta: Lesion or anomaly? Clin Radiol 36: 159-161. (Pubitemid 15162950)
14. Botto LD, Moore CA, Khoury MJ, Erickson JD,. 1999. Neural-tube defects. N Engl J Med 341: 1509-1519.
15. Bradtmiller B,. 1984. Congenital anomalies of the lower spine in two Ankara skeletal series. Plains Anthropol 29: 327-333.
16. Brailsford JF,. 1948. The Radiology of Bones and Joints. 4th Ed. London: J & A Churchill.
17. Branda RF, Eaton JW,. 1978. Skin color and nutrient phytolysis: An evolutionary hypothesis. Science 201: 625-626.
18. Brothwell DR, Powers R,. 1968. Congenital malformations of the skeleton in earlier man. In:, Brothwell DR, Sandison AT, editors. The Skeletal Biology of Earlier Human Populations. Oxford: Pergamon Press. p 173-203.
19. Bunner R,. 1959. Lateral intrathoracic meningocele. Acta Radiol 51: 1-9.
20. Burrows FG, Sutcliffe J,. 1968. The split notochord syndrome. Br J Radiol 41: 844-847.
21. Byrne RW, Hayes EA, George TM, McLone DG,. 1995. Operative resection of 100 spinal lipomas in infants less than 1 year of age. Pediatr Neurosurg 23: 182-187.
22. Carsin A, Journel H, Roussey M, Le Marec B,. 1986. Incidence of occult lumbo-sacral spina bifida in parents of children with spina bifida (concerning 80 pairs of parents with affected children). JGenet Hum 34: 285-292.
23. Carstairs V, Cole S,. 1984. Spina bifida and anencephaly in Scotland. Br Med J (Clin Res Ed) 289: 1182-1184. (Pubitemid 15208148)
24. Carter CO,. 1969. Spina bifida and anencephaly: A problem in genetic-environmental interaction. J Biosoc Sci 1: 71-83.
25. Carter CO, Evans K,. 1973. Spina bifida and anencephalus in greater London. J Med Genet 10: 209-234.
26. Carter CO, Evans KA, Till K,. 1976. Spinal dysraphism: Genetic relation to neural tube malformations. J Med Genet 13: 343-350.
27. Chanarin I,. 1979. The Megaloblastic Anaemias. 2nd Ed. Chicago: Blackwell Scientific Publications. 783 p.
28. Choi S, McComb JG,. 2000. Long-term outcome of terminal myelocystocele patients. Pediatr Neurosurg 32: 86-91. (Pubitemid 30337145)
29. Copp AJ,. 2005. Neurulation in the cranial region-normal and abnormal. J Anat 207: 623-635.
30. Copp AJ, Brook FA,. 1989. Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation? J Med Genet 26: 160-166.
31. Copp AJ, Greene ND, Murdoch JN,. 2003. The genetic basis of mammalian neurulation. Nat Rev Genet 4: 784-793.
32. Cotter AM, Daly SF,. 2005. Neural tube defects: Is a decreasing prevalence associated with a decrease in severity?. Eur J Obstet Gynecol Reprod Biol 119: 161-163. (Pubitemid 40460374)
33. Cowell MJ, Cowell HR,. 1976. The incidence of spina bifida occulta in idiopathic scoliosis. Clin Orthop Relat Res 118: 16-18.
34. Cowie TN,. 1956. Congenital spinal deformities of surgical importance. Acta Radiol 46: 38-47.
35. Craigmile TK,. 1977. Congenital anomalies of the spine. In:, Ruge D, Wiltse LL, editors. Spinal Disorders: Diagnosis and Treatment. Philadelphia: Lea and Febiger. p 223-245.
36. Czeizel AE, Dudás I,. 1992. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327: 1832-1835. (Pubitemid 23003073)
37. Danks DM, Halliday JL,. 1983. Incidence of neural tube defects in Victoria, Australia. Lancet 1: 65.
38. De Anquin CE,. 1959. Spina bifida occulta with engagement of the fifth lumbar spinous process: A cause of low back pain and sciatica. J Bone Joint Surg Br 41: 486-490.
39. De Bruyere M, Kulakowski S, Malchaire J, Delire M, Sokal G,. 1977. HLA gene and haplotype frequencies in spina bifida. Population and family studies. Tissue Antigens 10: 399-402. (Pubitemid 8252973)
40. De La Mata RC, Bonavia D,. 1980. Lumbosacral malformations and spina bifida in a Peruvian preceramic child. Curr Anthropol 21: 515-516.
41. Delashaw JB, Park TS, Cail WM, Vollmer DG,. 1987. Cervical meningocele and associated spinal anomalies. Childs Nerv Syst 3: 165-169.
42. Devor EJ, Cordell LS,. 1981. Neura-tube defects in prehistoric south-western Indian population. Ann Hum Biol 8: 65-75.
43. Dickel DN, Doran GH,. 1989. Severe neural tube defect syndrome from the Early Archaic of Florida. Am J Phys Anthropol 80: 325-334.
44. Drolet B,. 1998. Birthmarks to worry about. Cutaneous markers of dysraphism. Dermatol Clin 16: 447-453. (Pubitemid 28366882)
45. Dyck P, Wilson CB,. 1980. Anterior sacral meningocele. Case report. J Neurosurg 53: 548-552. (Pubitemid 10003565)
46. Eisenstein S,. 1978. Spondylolysis. A skeletal investigation of two population groups. J Bone Joint Surg Br 60: 488-494. (Pubitemid 9079988)
47. El-Din AMS, El-Banna RA,. 2004. Congenital anomalies of the vertebral column: A case study on ancient and modern Egypt. Int J Osteoarchaeol 16: 200-207.
48. Elton S, Oakes WJ,. 2001. Dermal sinus tracts of the spine. Neurosurg Focus 10: e4.
49. Emery JL, Lendon RG,. 1969. Lipomas of the cauda equina and other fatty tumours related to neurospinal dysraphism. Dev Med Child Neurol Suppl 20: 62-70.
50. Epstein HC,. 1976. The Spine: A Radiological Text and Atlas. 4th Ed. Philadelphia: Lea and Febiger.
51. Erşahin Y, Mutluer S, Kocaman S, Demirtas E,. 1998. Split cord malformations in children. J Neurosurg 88: 57-65.
52. Erşahin Y, Barçin E, Mutluer S,. 2001. Is meningocele really an isolated lesion? Childs Nerv Syst 17: 487-490. (Pubitemid 32684688)
53. Eubanks JD, Cheruvu VK,. 2009. Prevalence of sacral spina bifida occulta and its relationship to age, sex, race, and the sacral table angle: An anatomic, osteologic study of three thousand one hundred specimens. Spine 34: 1539-1543.
54. Ferembach D,. 1963. Frequency of spina bifida occulta in prehistoric human skeletons. Nature 199: 100-101.
55. Fidas A, MacDonald HL, Elton RA, Wild SR, Chisholm GD, Scott R,. 1987. Prevalence and patterns of spina bifida occulta in 2707 normal adults. Clin Radiol 38: 537-542. (Pubitemid 17142353)
56. Fineman RM, Jorde LB, Martin RA, Hasstedt SJ, Wing SD, Walker ML,. 1982. Spinal dysraphia as an autosomal dominant defect in four families. Am J Med Genet 12: 457-464.
57. Finnell RH, Gould A, Spiegelstein O,. 2003. Pathobiology and genetics of neural tube defects. Epilepsia 44 (Suppl 3): 14-23. (Pubitemid 36759082)
58. Ford FR,. 1960. Diseases of the Nervous System in Infancy, Childhood and Adolescence. 4th Ed. Springfield, IL: Charles C Thomas. 215 p.
59. French BN,. 1983. The embryology of spinal dysraphism. Clin Neurosurg 30: 295-340.
60. Frey L, Hauser WA,. 2003. Epidemiology of neural tube defects. Epilepsia 44 (Suppl 3): 4-13. (Pubitemid 36759081)
61. Galloway NT, Tainsh J,. 1985. Minor defects of the sacrum and neurogenic bladder dysfunction. Br J Urol 57: 154-155. (Pubitemid 15058896)
62. Gardner WJ,. 1980. Hypothesis; overdistention of the neural tube may cause anomalies of non-neural organs. Teratology 22: 229-238.
63. Gardner RJ, Alexander C, Veale AM,. 1974. Spina bifida occulta in the parents of offspring with neural tube defects. J Genet Hum 22: 389-395.
64. Garralda MD, Herrerin J, Vandermeersch B,. 2002. Child pathology in the mendicant's necropolis of El Burgo de Osma Cathedral (Soria. Spain). Bull Mem Soc Anthropol Paris 14: 311-325.
65. Geoffroy Saint-Hilaire E,. 1826. Note sur un monstre humain (anencéphale) trouvé dans les ruines de Thèbes en Egypte par M. Passalacqua. Arch Génér de Médecine 10: 154-126.
66. George TM, Wolpert CM, Worley G, Mackey JF, Fuchs HE, Speer MC,. 1996. Variable presentation of neural tube defects in three families. Am J Hum Genet A 93: 59.
67. Giuffre R,. 1966. Intradural spinal lipomas. Review of the literature (99 cases) and report of an additional case. Acta Neurochir 14: 69-95.
68. Green R, Miller JW,. 1999. Folate deficiency beyond megaloblastic anemia: Hyperhomocysteinemia and other manifestations of dysfunctional folate status. Semin Hematol 36: 47-64. (Pubitemid 29048612)
69. Gross RL, Reid JV, Newberne PM, Burgess B, Marston R, Hift W,. 1975. Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency. Am J Clin Nutr 28: 225-232.
70. Gupta SK, Gupta RC, Seth AK, Chaturvedi CS,. 1995. Increased incidence of spina bifida occulta in fluorosis prone areas. Acta Paediatr Jpn 37: 503-506.
71. Gutierrez FR, Woodard PK, Fleishman MJ,. 1994. Normal anatomy and congenital anomalies of the spine and spinal cord. In:, Osborn AG, Maack H, editors. Diagnostic Neuroradiology. 1st Ed. St. Louis: Mosby. p 785-819.
72. Hall PV, Campbell RL, Kalsbeck JE,. 1975. Meningomyelocele and progressive hydromyelia. Progressive paresis in myelodysplasia. J Neurosurg 43: 457-463.
73. Hall JG, Friedman JM, Kenna BA, Popkin J, Jawanda M, Arnold W,. 1988. Clinical, genetic and epidemiological factors in neural tube defects. Am J Hum Genet 43: 827-837. (Pubitemid 19018984)
74. Harrison RJ,. 1981. Bones. In:, Romanes GJ, editor. Cunningham's Textbook of Anatomy. 12th Ed. Oxford, UK: Oxford University Press. p 75-210.
75. Hendrick EB, Hoffman HJ, Humphreys RP,. 1983. The tethered spinal cord. Clin Neurosurg 30: 457-463.
76. Henneberg RJ, Henneberg M,. 1999. Variation in the closure of the sacral canal in the skeletal sample from Pompeii, Italy, 79 AD. Perspect Hum Biol 4: 177-188.
77. Hoffman EP,. 1965. The problems of spina bifida and cranium bifidum: A survey of contemporary ideas. Clin Pediatr 4: 709-716.
78. Hunter AG,. 1993. Brain and spinal cord. In:, Stevenson RE, Hall JG, Goodman RM, editors. Human Malformations and Related Anomalies, Vol II. New York: Oxford University Press. p 109-137.
79. James CC, Lassman LP,. 1962. Spinal dysraphism: the diagnosis and treatment of progressive lesions in spina bifida occulta. J Bone Joint Surg Am 44: 828-840.
80. Jones PH, Love JG,. 1956. Tight filum terminale. AMA Arch Surg 73: 556-566.
81. Jorde LB, Fineman RM, Martin RA,. 1983. Epidemiology and genetics of neural tube defects: an application of the Utah Genealogical Data Base. Am J Phys Anthropol 62: 23-31.
82. Kallen B, Winberg J,. 1974. Caudal mesoderm pattern of anomalies: From renal agenesis to sirenomelia. Teratology 9: 99-111.
83. Kanev PM, Park TS,. 1995. Dermoids and dermal sinus tracts of the spine. Neurosurg Clin N Am 6: 359-366.
84. Kannu P, Furneaux C, Aftimos S,. 2004. Familial lipomyelomeningocele: A further report. Am J Med Genet A 132A: 90-92. (Pubitemid 40070569)
85. Kibar Z, Torban E, McDearmid JR, Reynolds A, Berghout J, Mathieu M, Kirillova I, De Marco P, Merello E, Hayes JM, Wallingford JB, Drapeau P, Capra V, Gros P,. 2007. Mutations in VANGL1 associated with neural-tube defects. N Engl J Med 356: 1432-1437. (Pubitemid 46556328)
86. Kim SY, McGahan JP, Boggan JE, McGrew W,. 2000. Prenatal diagnosis of lipomyelomeningocele. J Ultrasound Med 19: 801-805.
87. Korsvik HE, Keller MS,. 1992. Sonography of occult dysraphism in neonates and infants with MR imaging correlation. Radiographics 12: 297-306.
88. Kumar R, Singh SN,. 2003. Spinal dysraphism: Trends in northern India. Pediatr Neurosurg 38: 133-145. (Pubitemid 36302461)
89. Kumar R, Singh V,. 2004. Intramedullary mass lesion of the spinal cord in children of a developing milieu. Pediatr Neurosurg 40: 16-22. (Pubitemid 38338505)
90. Lassman LP, James CC,. 1977. Meningocele manqué. Childs Brain 3: 1-11.
91. Laurence KM,. 1974. Effect of early surgery for spina bifida cystica on survival and quality of life. Arch Dis Child 56: 822-830.
92. Laurence KM, Bligh AS, Evans KT,. 1968. Vertebral and other abnormalities in parents and sibs of cases of spina bifida cystica and anencephaly. Dev Med Child Neurol Suppl 16: 107.
93. Laurence KM, Bligh AS, Evans KT, Shurtleff DB,. 1971. Vertebral abnormalities in parents and sibs of cases of spina bifida cystica, encephalocele and anencephaly. Proceedings of the 13th International Congress of Pediatrics 5: 415-421.
94. Lawrence JS,. 1977. Rheumatism in Populations. London: William Heinemann Medical Books. 572 p.
95. Lemire RJ,. 1988. Neural tube defects. JAMA 259: 558-562.
96. List CF,. 1941. Intraspinal epidermoids, dermoids and dermal sinuses. Surg Gynecol Obstet 73: 525-538.
97. Lorber J, Levick K,. 1967. Spina bifida cystica. Incidence of spina bifida occulta in parents and in controls. Arch Dis Child 42: 171-173.
98. Lorber J, Ward AM,. 1985. Spina bifida - A vanishing nightmare? Arch Dis Child 60: 1086-1091. (Pubitemid 16194253)
99. Love JG, Daly DD, Harris LE,. 1961. Tight filum terminale: Report of condition in three siblings. JAMA 176: 31-33.
100. Lunardi P, Missori P, Gagliardi FM, Fortuna A,. 1989. Long-term results of the surgical treatment of spinal dermoid and epidermoid tumors. Neurosurgery 25: 860-864. (Pubitemid 20073376)
101. Macchiarelli R,. 1989. Prehistoric "fish-eaters" along the eastern Arabian coasts: dental variation, morphology, and oral health in the Ra's al-Hamra community (Qurum. Sultanate of Oman, 5th-4th millennia BC). Am J Phys Anthropol 78: 575-594. (Pubitemid 19093011)
102. Masnicova S, Benus R,. 2003. Developmental anomalies in skeletal remains from the Great Moravia and Middle Ages cemeteries at Devin (Slovakia). Int J Osteoarchaeol 13: 266-274. (Pubitemid 40355715)
103. Mathews S, Cope D, Wheeler S, Dupras T,. 2009. Lethal neural tube defects from the Dakhleh Oasis, Egypt: an analysis of three cases. Poster presented at the 78th Annual Meeting of the American Association of Physical Anthropologists, Chicago.
104. McComb JG,. 1997. Spinal and cranial neural tube defects. Semin Pediatr Neurol 4: 156-166. (Pubitemid 27411314)
105. McKusick VA,. 1998. Mendelian Inheritance in Man: Catalogues of Human Genes and Genetic Disorders. 12th Ed. Baltimore: John Hopkins University Press. 3972 p.
106. McLone DG,. 1999. Occult dysraphism and the tethered spinal cord lipomas. In:, Choix M, Di Rocco C, Walker ML, Hockley A, editors. Pediatric Neurosurgery. 1st Ed. Philadelphia: Churchill Livingston. p 61-78.
107. McNeely PD, Howes WJ,. 2004. Ineffectiveness of dietary folic acid supplementation on the incidence of lipomyelomeningocele: pathogenetic implications. J Neurosurg 100 (Suppl): 98-100.
108. Medow J, Sansone J, Iskandar BJ,. 2007. Syringomyelia and hydromyelia. In:, Albright AL, Pollack IF, Adelson PD, editors. Principles and Practice of Pediatric Neurosurgery. 2nd Ed. New York: Thieme. p 444-473.
109. Melvin EC, George TM, Worley G, Franklin A, Mackey J, Viles K, Shah N, Drake CR, Enterline DS, McLone D, Nye J, Oakes WJ, McLaughlin C, Walker ML, Peterson P, Brei T, Buran C, Aben J, Ohm B, Bermans I, Qumsiyeh M, Vance J, Pericak-Vance MA, Speer MC,. 2000. Genetic studies in neural tube defects. NTD Collaborative Group. Pediatr Neurosurg 32: 1-9. (Pubitemid 30205189)
110. Milham S Jr,. 1962. Increased incidence of anencephalus and spina bifida in siblings of affected cases. Science 138: 593-594.
111. Miller JR, Fraser FC, MacEwan DW,. 1962. The frequency of spina bifida occulta and rib anomalies in the parents of children with spina bifida aperta and meningocele. Am J Hum Genet 14: 245-248.
112. Mills JL, Scott JM, Kirke PN, McPartlin JM, Conley MR, Weir DG, Molloy AM, Lee YJ,. 1996. Homocysteine and neural tube defects. J Nutr 126: 756S-760S.
113. Miyazato M, Sugaya K, Nishijima S, Owan T, Ogawa Y,. 2007. Location of spina bifida occulta and ultrasonographic bladder abnormalities predict the outcome of treatment for primary nocturnal enuresis in children. Int J Urol 14: 33-38. (Pubitemid 44952579)
114. Moore CA,. 2006. Classification of neural tube defects. In:, Wyszynski DF, editor. Neural Tube Defects: From Origin to Treatment. New York: Oxford University Press. p 66-75.
115. Morris GF, Murphy K, Rorke LB, James HE,. 1998. Spinal hamartomas: A distinct clinical entity. J Neurosurg 88: 954-957. (Pubitemid 28261839)
116. Morrison K, Papapetrou C, Hol FA, Mariman EC, Lynch SA, Burn J, Edwards YH,. 1998. Susceptibility to spina bifida; an association study of five candidate genes. Ann Hum Genet 62: 379-396. (Pubitemid 29083996)
117. Morse D,. 1978. Ancient Disease in the Midwest. 2nd Ed. Springfield, IL: Illinois State Museum Reports of Investigations.
118. Mount LA,. 1949. Congenital dermal sinuses as a cause of meningitis, intraspinal abscess and intracranial abscess. J Am Med Assoc 139: 1263-1268.
119. MRC Vitamin Study Research Group. 1991. Prevention of neural tube defects: Results of the Medical Research Council vitamin study. Lancet 338: 131-137.
120. Myles ST, Hamilton MG,. 2007. Intraspinal congenital cysts: Neurenteric, arachnoid, dermoid and epidermoid. In:, Albright AL, Pollack IF, Adelson PD, editors. Principles and Practice of Pediatric Neurosurgery. 2nd Ed. Thieme: New York. p 415-424.
121. Naidich TP,. 1988. The pediatric spine and cord: Developmental and congenital abnormalities. In: Categorical Course on Spine and Cord Imaging. Oak Brook: American Society of Neuroradiology. p 1-15.
122. Naidich TP, Raybaud C,. 1992. Congenital anomalies of the spine and spinal cord. Rev Neurol 5 (Suppl 2): 113-130.
123. Naidich TP, McLone DG, Harwood-Nash DC,. 1983. Spinal dysraphism. In:, Newton TH, Potts DG, editors. Modern Neuroradiology, Vol 1:Computed Tomography of the Spine and Spinal Cord. San Anselmo: Clavadel Press. p 299-353.
124. Naidich TP, Blaser SI, Bradley ND, McLone DG, Dias MS, Zimmerman RA, Raybaud CA, Birchansky SB, Altman NR, Braffman BH,. 2002. Congenital anomalies of the spine and spinal cord: embryology and malformations. In:, Atlas SW, editor. Magnetic Resonance Imaging of the Brain and Spine. 3rd Ed. Philadelphia: Lippincott, Williams & Wilkins. p 1527-1632.
125. Northrup H, Volcik KA,. 2000. Spina bifida and other neural tube defects. Curr Probl Pediatr 30: 313-332.
126. Ortner DJ,. 2003. Identification of Pathological Conditions in Human Skeletal Remains. Washington, DC: Smithsonian Institution Press. 645 p.
127. Ortner DJ, Garofalo EM, Frohlich B,. 2008. The paleopathology of the EB IA and EB IB people. In:, Ortner DJ, Frohlich B, editors. The Early Bronze Age I Tombs and Burials of Bâb edh-Dhrâ, Jordan. New York: Altamira Press. p 263-280.
128. Owens JR, Harris F, McAllister E, West L,. 1981. 19-year incidence of neural tube defects in area under constant surveillance. Lancet 2: 1032-1035. (Pubitemid 11027587)
129. Padmanabhan R,. 1984. Experimental induction of cranioschisis aperta and exencephaly after neural tube closure. A rat model. J Neurol Sci 66: 235-243. (Pubitemid 15187602)
130. Padmanabhan R,. 2006. Etiology, pathogenesis and prevention of neural tube defects. Congenit Anom 46: 55-67. (Pubitemid 43752225)
131. Padmanabhan R, Hameed MS,. 1985. Malformations of the axial skeleton in cranioschisis aperta and exencephaly in rat fetuses induced after neural tube closure. Virchows Arch A Pathol Anat Histopathol 408: 61-73. (Pubitemid 16192012)
132. Page LK,. 1985. Occult spinal dysraphism and related disorders. In:, Wilkins RH, Rengachary SS, editors. Neurosurgery. Vol III. 2nd Ed. New York: McGraw-Hill. p 2053-2057.
133. Papp T, Porter RW,. 1994. Changes of the lumbar spinal canal proximal to spina bifida occulta. An archaeologic study with clinical significance. Spine 19: 1508-1511. (Pubitemid 24226888)
134. Penrose LS,. 1946. Familial data on 144 cases of anencephaly, spina bifida and congenital hydrocephaly. Ann Eugen 13: 75-98.
135. Pietrusewsky M, Douglas MT,. 1993. The skeletal biology of an historic Hawaiian cemetery: Familial relationships. Homo 43: 245-262.
136. Post RH,. 1966. Pilot study: Population differences in the frequency of spina bifida occulta. Eugen Q 13: 341-352.
137. Powell KR, Cherry JD, Hougen TJ, Blinderman EE, Dunn MC,. 1975. A prospective search for congenital dermal abnormalities of the craniospinal axis. J Pediatr 87: 744-750.
138. Rankin J, Glinianaia S, Brown R, Renwick M,. 2000. The changing prevalence of neural tube defects: A population-based study in the north of England, 1984-96. Northern congenital abnormality survey steering group. Paediatr Perinat Epidemiol 14: 104-110.
139. Relton CL, Wilding CS, Jonas PA, Lynch SA, Tawn EJ, Burn J,. 2003. Genetic susceptibility to neural tube defect pregnancy varies with offspring phenotype. Clin Genet 64: 424-428. (Pubitemid 37406892)
140. Roberts CA, Manchester K,. 2007. The Archaeology of Disease. Ithaca, New York: Cornell University Press.
141. Rodríguez-Martín C,. 1995. Patologia de la Columna vertebral en poblaciones del Pasado. Revision en la poblacion prehispanica de Tenerife (Spinal pathology in past populations. A review in the prehispanic population of Tenerife). ERES-Serie de Arqueologia 6: 157-170.
142. Rösing FW,. 1982. A critical review of quasi-continuous variation of the human skeleton. Homo 33: 100-125.
143. Sadler TW,. 2005. Embryology of neural tube development. Am J Med Genet C Semin Med Genet 135C: 2-8.
144. Saluja PG,. 1986. Evidence of spina bifida in skeletal remains from Ireland. Ir Med J 79: 145-149.
145. Saluja PG,. 1988. The incidence of spina bifida occulta in a historic and a modern London population. J Anat 158: 91-93.
146. Scheuer L, Black S,. 2004. The Juvenile Skeleton. San Diego: Elsevier Academic Press.
147. Schmorl G, Junghanns H,. 1971. The Human Spine in Health and Disease. 2nd Ed. New York: Grune and Stratton. 285 p.
148. Schut L, Pizzi FJ, Bruce DA,. 1977. Occult spinal dysraphism. In:, McLaurin RL, editor. Myelomeningocele. New York: Grune & Stratton. p 349-368.
149. Schwidde JT,. 1952. Spina bifida: Survey of two hundred twenty-five encephaloceles, meningoceles and myelomeningoceles. AMA Am J Dis Child 84: 35-51.
150. Sebold CD, Melvin EC, Siegel D, Mehltretter L, Enterline DS, Nye JS, Kessler J, Bassuk A, Speer MC, George TM,; NTD Collaborative Group. 2005. Recurrence risks for neural tube defects in siblings of patients with lipomyelomeningocele. Genet Med 7: 64-67. (Pubitemid 40111134)
151. Seller MJ,. 1994. Risks in spina bifida. Dev Med Child Neurol 36: 1021-1025.
152. Shang Y, Zhao H, Niu B, Li WI, Zhou R, Zhang T, Xie J,. 2008. Correlation of polymorphism of MTHFRs and RFC-1 genes with neural tube defects in China. Birth Defects Res A Clin Mol Teratol 82: 3-7. (Pubitemid 351157084)
153. Southworth JD, Bersack SR,. 1950. Anomalies of the lumbosacral vertebrae in 550 individuals without symptoms referable to the low back. Am J Roentgenol Radium Ther 64: 624-634.
154. Stamm DS, Siegel DG, Mehltretter L, Connelly JJ, Trott A, Ellis N, Zismann V, Stephan DA, George TM, Vekemans M, Ashley-Koch A, Gilbert JR, Gregory SG, Speer MC,; NTD Collaborative Group. 2008. Refinement of 2q and 7p loci in a large multiplex NTD family. Birth Defects Res A Clin Mol Teratol 82: 441-452. (Pubitemid 351934127)
155. Sulik KK, Sadler TW,. 1993. Postulated mechanisms underlying the development of neural tube defects. Insights from in vitro and in vivo studies. Ann N Y Acad Sci 678: 8-21.
156. Superina RA, Ein EH, Humphreys RP,. 1984. Cystic duplications of the esophagus and neurenteric cysts. J Pediatr Surg 19: 527-530.
157. Sutow WW, Pryde AW,. 1956. Incidence of spina bifida occulta in relation to age. AMA J Dis Child 91: 211-217.
158. Sutton LN,. 1995. Lipomyelomeningocele. Neurosurg Clin N Am 6: 325-338.
159. Tan KB, Tan SH, Tan KH, Yeo GS,. 2007. Anencephaly in Singapore: A ten-year series 1993-2002. Singapore Med J 48: 12-15.
160. Tibbs PA, James HE, Rorke LB, Schut L, Bruce DA,. 1976. Midline hamartomas masquerading as meningomyeloceles or teratomas in the newborn infant. J Pediatr 89: 928-933.
161. Toriello HV, Higgins JV,. 1985. Possible causal heterogeneity in spina bifida cystica. Am J Med Genet 21: 13-20. (Pubitemid 15040435)
162. Tortori-Donati P, Rossi A, Cama A,. 2000. Spinal dysraphism: A review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology 42: 471-491. (Pubitemid 30603964)
163. Turkel SJ,. 1989. Congenital abnormalities in skeletal populations. In:, Işcan MY, Kennedy KAR, editors. Reconstruction of Life from the Skeleton. New York: AR Liss. p 109-127.
164. Ubelaker DH,. 1989. Human Skeletal Remains. 2nd Ed. Washington, DC: Taraxacum Press. 184 p.
165. Van Allen MI,. 1996. Multisite neural tube closure in humans. Birth Defects Orig Artic Ser 30: 203-225.
166. Van Allen MI, Kalousek DK, Chernoff GF, Juriloff D, Harris M, McGillivray BC, Yong SL, Langlois S, MacLeod PM, Chitayat D, Friedman JM, Wilson RD, McFadden D, Pantzar J, Ritchie S, Hall JG,. 1993. Evidence for multisite closure of the neural tube in humans. Am J Med Genet 47: 723-743. (Pubitemid 23291992)
167. Vannier JP, Lefort J, Cavelier B, Ledosseur P, Assailly C, Feingold J,. 1981. Spina bifida cystica families X-ray examination and HLA typing. Pediatr Res 15: 326-329. (Pubitemid 11106104)
168. Walker PL, Bathurst RR, Richman R, Gjerdrum T, Andrushko VA,. 2009. The causes of porotic hyperostosis and cribra orbitalia: a reappraisal of the iron-deficiency-anemia hypothesis. Am J Phys Anthropol 139: 109-125.
169. Warder DE,. 2001. Tethered cord syndrome and occult spinal dysraphism. Neurosurg Focus 10: 1-9. (Pubitemid 32125086)
170. Webb S,. 1995. Paleopathology of Aboriginal Australians: Health and Disease Across a Hunter-Gatherer Continent. Cambridge: Cambridge University Press. 336 p.
171. Wentz RK,. 2004. Examination of subadult pathology in a 7000-year-old population from Florida. Florida Anthropol 57: 219-227.
172. Westcott MA, Dynes MCK, Remer EM, Donaldson JS, Dias LS,. 1992. Congenital and acquired orthopedic abnormalities in patients with myelomeningocele. Radiographics 12: 1155-1173.
173. White FM, Cohen FG, Sherman G, McCurdy R,. 1988. Chemicals, birth defects and stillbirths in New Brunswick: Associations with agricultural activity. CMAJ 138: 117-124. (Pubitemid 18054603)
174. Williams PL,. (ed.) 1995. Gray's Anatomy. New York: Churchill Livingstone. 2092 p.
175. Witczak M, Ferenc T, Wilczyński J,. 2007. Pathogenesis and genetics of neural tube defects. Ginekol Pol 78: 981-985.
176. Wright RL,. 1971. Congenital dermal sinuses. Prog Neurol Surg 4: 175-191.
177. Wyszynski DF,. 2006. Maternal exposure to selected environmental factors and risk for neural tube defects in the offspring. In:, Wyszynski DF, editor. Neural Tube Defects: From Origin to Treatment. New York: Oxford University Press. p 133-161.
178. Yamada S, Zinke DE, Sanders D,. 1981. Pathophysiology of "tethered cord syndrome". J Neurosurg 54: 494-503.
179. Zimmerman MR, Kelly MA,. 1982. Atlas of Human Paleopathology. New York: Praeger. 220 p.