Closing the anion gap: Contribution of d-lactate to diabetic ketoacidosis

Clinica Chimica Acta

Volumn 412, Issue 3-4, 2011, Pages 286-291

  Lu, Jianxin ^a,b   Zello, Gordon A ^c   Randell, Edward ^d   Adeli, Khosrow ^e   Krahn, John ^b   Meng, Qing H ^a,b  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b ROYAL UNIVERSITY HOSPITAL   (Canada)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Anion gap; D lactate; Diabetes; Diabetic ketoacidosis; Methylglyoxal

Indexed keywords

3 HYDROXYBUTYRIC ACID; BICARBONATE; GLUCOSE; HEMOGLOBIN A1C; LACTIC ACID; METHYLGLYOXAL;

ADULT; ANION GAP; ARTICLE; BICARBONATE BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC KETOACIDOSIS; DIABETIC PATIENT; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LABORATORY TEST; LACTATE BLOOD LEVEL; LIQUID CHROMATOGRAPHY; MALE; METABOLIC ACIDOSIS; PATHOGENESIS; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

3-HYDROXYBUTYRIC ACID; BICARBONATES; BLOOD GLUCOSE; DIABETIC KETOACIDOSIS; FEMALE; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; PYRUVALDEHYDE;

EID: 78650249735     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.10.020     Document Type: Article

References (34)

1. Kitabchi A.E., Umpierrez G.E., Murphy M.B., Kreisberg R.A. Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association. Diab Care 2006, 29:2739-2748.
2. Rackow E.C., Mecher C., Astiz M.E., Goldstein C., McKee D., Weil M.H. Unmeasured anion during severe sepsis with metabolic acidosis. Circ Shock 1990, 30:107-115.
3. Corey H.E. The anion gap (AG): studies in the nephrotic syndrome and diabetic ketoacidosis (DKA). J Lab Clin Med 2006, 147:121-125.
4. Fulop M., Murthy V., Michilli A., Nalamati J., Qian Q., Saitowitz A. Serum beta-hydroxybutyrate measurement in patients with uncontrolled diabetes mellitus. Arch Intern Med 1999, 159:381-384.
5. Sheikh-Ali M., Karon B.S., Basu A., et al. Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis?. Diab Care 2008, 31:643-647.
6. Forni L.G., McKinnon W., Lord G.A., Treacher D.F., Peron J.M., Hilton P.J. Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis. Crit Care 2005, 9:R591-R595.
7. Kraut J.A., Madias N.E. Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol 2007, 2:162-174.
8. Ewaschuk J.B., Naylor J.M., Zello G.A. d-lactate in human and ruminant metabolism. J Nutr 2005, 135:1619-1625.
9. McLellan A.C., Phillips S.A., Thornalley P.J. Fluorimetric assay of d-lactate. Anal Biochem 1992, 206:12-16.
10. Thornalley P.J. The glyoxalase system in health and disease. Mol Aspects Med 1993, 14:287-371.
11. Kalapos M.P. Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications. Toxicol Lett 1999, 110:145-175.
12. Wang H., Meng Q.H., Gordon J.R., Khandwala H., Wu L. Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus. Clin Biochem 2007, 40:1232-1239.
13. Beisswenger P.J., Howell S.K., Touchette A.D., Lal S., Szwergold B.S. Metformin reduces systemic methylglyoxal concentrations in type 2 diabetes. Diabetes 1999, 48:198-202.
14. Beisswenger P.J., Drummond K.S., Nelson R.G., Howell S.K., Szwergold B.S., Mauer M. Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. Diabetes 2005, 54:3274-3281.
15. Uribarri J., Oh M.S., Carroll H.J. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms. Medicine 1998, 77:73-82.
16. Kondoh Y., Kawase M., Kawakami Y., Ohmori S. Concentrations of d-lactate and its related metabolic intermediates in liver, blood, and muscle of diabetic and starved rats. Res Exp Med (Berl) 1992, 192:407-414.
17. Christopher M.M., Broussard J.D., Fallin C.W., Drost N.J., Peterson M.E. Increased serum d-lactate associated with diabetic ketoacidosis. Metabolism 1995, 44:287-290.
18. Hasegawa H., Fukushima T., Lee J.A., et al. Determination of serum d-lactic and l-lactic acids in normal subjects and diabetic patients by column-switching HPLC with pre-column fluorescence derivatization. Anal Bioanal Chem 2003, 377:886-891.
19. Ahmed N., Battah S., Karachalias N., et al. Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency. Biochim Biophys Acta 2003, 1639:121-132.
20. Beisswenger B.G., Delucia E.M., Lapoint N., Sanford R.J., Beisswenger P.J. Ketosis leads to increased methylglyoxal production on the Atkins diet. Ann NY Acad Sci 2005, 1043:201-210.
21. Talasniemi J.P., Pennanen S., Savolainen H., Niskanen L., Liesivuori J. Analytical investigation: assay of d-lactate in diabetic plasma and urine. Clin Biochem 2008, 41:1099-1103.
22. McLellan A.C., Thornalley P.J., Benn J., Sonksen P.H. Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. Clin Sci (Lond) 1994, 87:21-29.
23. American Diabetes Association Standards of medical care in diabetes. Diab Care 2007, 30:S4-S41.
24. Han Y., Randell E., Vasdev S., et al. Plasma methylglyoxal and glyoxal are increased and related to early membrane alteration in young, complication-free patients with type 1 diabetes. Mol Cell Biochem 2007, 305:123-131.
25. Han Y., Randell E., Vasdev S., et al. Plasma advanced glycation endproduct, methylglyoxal-derived hydroimidazolone is increased in young, complication-free patients with type 1 diabetes. Clin Biochem 2009, 42:562-569.
26. Omole O.O., Nappert G., Naylor J.M., Zello G.A. Both l- and d-lactate contribute to metabolic acidosis in diarrheic calves. J Nutr 2001, 131:2128-2131.
27. Stephens J.M., Sulway M.J., Watkins P.J. Relationship of blood acetoacetate and 3- hydroxybutyrate in diabetes. Diabetes 1971, 20:485-489.
28. Thornalley P.J. Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification - a role in pathogenesis and antiproliferative chemotherapy. Gen Pharmacol 1996, 27:565-573.
29. Lapolla A., Flamini R., Dalla Vedova A., et al. Glyoxal and methylglyoxal concentrations in diabetic patients: quantitative determination by a new GC/MS method. Clin Chem Lab Med 2003, 41:1166-1173.
30. Kilhovd B.K., Giardino I., Torjesen P.A., et al. Increased serum concentrations of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes. Metabolism 2003, 52:163-167.
31. Nemet I., Turk Z., Duvnjak L., Car N., Varga-Defterdarovic L. Humoral methylglyoxal concentration reflects glycemic fluctuation. Clin Biochem 2005, 38:379-383.
32. Thornalley P.J. Modification of the glyoxalase system in human red blood cells by glucose in vitro. Biochem J 1988, 254:751-755.
33. Thornalley P.J. The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life. Biochem J 1990, 269:1-11.
34. Yan S.F., Ramasamy R., Schmidt A.M. The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature. Circ Res 2010, 106:842-853.