-
3
-
-
0041629528
-
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
-
Vogelzang NJ, Rusthoven JJ, Symanowski J, ,Denham C, Kaukel E, Ruffle P, Gatzemeier U, Boyer M, Emri S, Manegold C, Niyikiza C and Paoletti P: Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 21: 2636-2644, 2003.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2636-2644
-
-
Vogelzang, N.J.1
Rusthoven, J.J.2
Symanowski, J.3
Denham, C.4
Kaukel, E.5
Ruffle, P.6
Gatzemeier, U.7
Boyer, M.8
Emri, S.9
Manegold, C.10
Niyikiza, C.11
Paoletti, P.12
-
4
-
-
26444458845
-
Advances in malignant mesothelioma
-
Robinson BW and Lake RA: Advances in malignant mesothelioma. N Engl J Med 353: 1591-603, 2005.
-
(2005)
N Engl J Med
, vol.353
, pp. 1591-1603
-
-
Robinson, B.W.1
Lake, R.A.2
-
5
-
-
0030891198
-
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
-
Shih C, Chen VJ, Gossett LS, Gates SB, MacKellar WC, Habeck LL, Shackelford KA, Mendelsohn LG, Soose DJ, Patel VF, Andis SL, Bewley JR, Rayl EA, Moroson BA, Beardsley GP, Kohler W, Ratnam M, and Schultz RM: LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 57: 1116-1123, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 1116-1123
-
-
Shih, C.1
Chen, V.J.2
Gossett, L.S.3
Gates, S.B.4
MacKellar, W.C.5
Habeck, L.L.6
Shackelford, K.A.7
Mendelsohn, L.G.8
Soose, D.J.9
Patel, V.F.10
Andis, S.L.11
Bewley, J.R.12
Rayl, E.A.13
Moroson, B.A.14
Beardsley, G.P.15
Kohler, W.16
Ratnam, M.17
Schultz, R.M.18
-
6
-
-
33749587054
-
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
-
Ceppi P, Volante M, Saviozzi S, Rapa I, Novello S, Cambieri A, Lo Iacono M, Cappia S, Papotti M, and Scagliotti GV: Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer 107: 1589-1596, 2006.
-
(2006)
Cancer
, vol.107
, pp. 1589-1596
-
-
Ceppi, P.1
Volante, M.2
Saviozzi, S.3
Rapa, I.4
Novello, S.5
Cambieri, A.6
Lo Iacono, M.7
Cappia, S.8
Papotti, M.9
Scagliotti, G.V.10
-
7
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small cell lung cancer
-
Scagliotti GV, Parikh P, von Pawel J, Biesma B, Vansteenkiste J, Manegold C, Serwatowski P, Gatzemeier U, Digumarti R, Zukin M, Lee JS, Mellemgaard A, Park K, Patil S, Rolski J, Goksel T, de Marinis F, Simms L, Sugarman KP, and Gandara D Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small cell lung cancer. J Clin Oncol 26: 3543-51, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
Von Pawel, J.3
Biesma, B.4
Vansteenkiste, J.5
Manegold, C.6
Serwatowski, P.7
Gatzemeier, U.8
Digumarti, R.9
Zukin, M.10
Lee, J.S.11
Mellemgaard, A.12
Park, K.13
Patil, S.14
Rolski, J.15
Goksel, T.16
De Marinis, F.17
Simms, L.18
Sugarman, K.P.19
Gandara, D.20
more..
-
8
-
-
70350225538
-
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small cell lung cancer: A randomised, double-blind, phase 3 study
-
Ciuleanu T, Brodowicz T, Zielinski C, Kim JH, Krzakowski M, Laack E, Wu YL, Bover I, Begbie S, Tzekova V, Cucevic B, Pereira JR, Yang SH, Madhavan J, Sugarman KP, Peterson P, John WJ, Krejcy K, and Belani CP: Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 374: 1432-1440, 2009.
-
(2009)
Lancet
, vol.374
, pp. 1432-1440
-
-
Ciuleanu, T.1
Brodowicz, T.2
Zielinski, C.3
Kim, J.H.4
Krzakowski, M.5
Laack, E.6
Wu, Y.L.7
Bover, I.8
Begbie, S.9
Tzekova, V.10
Cucevic, B.11
Pereira, J.R.12
Yang, S.H.13
Madhavan, J.14
Sugarman, K.P.15
Peterson, P.16
John, W.J.17
Krejcy, K.18
Belani, C.P.19
-
9
-
-
33847745417
-
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels
-
Giovannetti E, Backus HH, Wouters D, Ferreira CG, van Houten VM, Brakenhoff RH, Poupon MF, Azzarello A, Pinedo HM, and Peters GJ: Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. Br J Cancer 96: 769-775, 2007.
-
(2007)
Br J Cancer
, vol.96
, pp. 769-775
-
-
Giovannetti, E.1
Backus, H.H.2
Wouters, D.3
Ferreira, C.G.4
Van Houten, V.M.5
Brakenhoff, R.H.6
Poupon, M.F.7
Azzarello, A.8
Pinedo, H.M.9
Peters, G.J.10
-
10
-
-
0036203913
-
A phase II EORTC study of temozolomide in patients with malignant pleural mesothelioma
-
EORTC Lung Cancer Group
-
van Meerbeeck JP, Baas P, Debruyne C, Smit EF, van Klaveren RJ, Galdermans D, Lentz MA, Manegold C, and Giaccone G; EORTC Lung Cancer Group: A phase II EORTC study of temozolomide in patients with malignant pleural mesothelioma. Eur J Cancer 38: 779-83, 2002.
-
(2002)
Eur J Cancer
, vol.38
, pp. 779-783
-
-
Van Meerbeeck, J.P.1
Baas, P.2
Debruyne, C.3
Smit, E.F.4
Van Klaveren, R.J.5
Galdermans, D.6
Lentz, M.A.7
Manegold, C.8
Giaccone, G.9
-
11
-
-
65349091355
-
Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer
-
Smit EF, Burgers SA, Biesma B, Smit HJ, Eppinga P, Dingemans AM, Joerger M, Schellens JH, Vincent A, van Zandwijk N, and Groen HJ: Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer. J Clin Oncol 27: 2038-2045, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2038-2045
-
-
Smit, E.F.1
Burgers, S.A.2
Biesma, B.3
Smit, H.J.4
Eppinga, P.5
Dingemans, A.M.6
Joerger, M.7
Schellens, J.H.8
Vincent, A.9
Van Zandwijk, N.10
Groen, H.J.11
-
12
-
-
20244374653
-
Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma
-
Hughes A, Calvert P, Azzabi A, Plummer R, Johnson R, Rusthoven J, Griffin M, Fishwick K, Boddy AV, Verrill M, and Calvert H: Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma. J Clin Oncol. 20: 3533-3544, 2002.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3533-3544
-
-
Hughes, A.1
Calvert, P.2
Azzabi, A.3
Plummer, R.4
Johnson, R.5
Rusthoven, J.6
Griffin, M.7
Fishwick, K.8
Boddy, A.V.9
Verrill, M.10
Calvert, H.11
-
13
-
-
2342612162
-
Second-line chemotherapy for non-small cell lung cancer: Recent data with pemetrexed
-
Hanna NH. Second-line chemotherapy for non-small cell lung cancer: recent data with pemetrexed. Clin Lung Cancer 2: 75-79, 2004.
-
(2004)
Clin Lung Cancer
, vol.2
, pp. 75-79
-
-
Hanna, N.H.1
-
14
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors
-
Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC, and Gwyther SG: New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92: 205-216, 2002. (Pubitemid 30099779)
-
(2000)
Journal of the National Cancer Institute
, vol.92
, Issue.3
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
Wanders, J.4
Kaplan, R.S.5
Rubinstein, L.6
Verweij, J.7
Van Glabbeke, M.8
Van Oosterom, A.T.9
Christian, M.C.10
Gwyther, S.G.11
-
15
-
-
0030912190
-
Revisions in the International System for Staging Lung Cancer
-
Mountain CF: Revisions in the International System for Staging Lung Cancer. Chest 111: 1710-1717, 1997.
-
(1997)
Chest
, vol.111
, pp. 1710-1717
-
-
Mountain, C.F.1
-
16
-
-
0028825114
-
A proposed new international TNM staging system for malignant pleural mesothelioma
-
International Mesothelioma Interest Group (IMIG)
-
Rusch VW. International Mesothelioma Interest Group (IMIG): A proposed new international TNM staging system for malignant pleural mesothelioma. Chest 108: 1122-1128, 1995,
-
(1995)
Chest
, vol.108
, pp. 1122-1128
-
-
Rusch, V.W.1
-
17
-
-
77951879838
-
Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status
-
Onitsuka T, Uramoto H, Ono K, Takenoyama M, Hanagiri T, Oyama T, Izumi H, Kohno K, and Yasumoto K: Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status. J Thorac Oncol 5: 591-596, 2010.
-
(2010)
J Thorac Oncol
, vol.5
, pp. 591-596
-
-
Onitsuka, T.1
Uramoto, H.2
Ono, K.3
Takenoyama, M.4
Hanagiri, T.5
Oyama, T.6
Izumi, H.7
Kohno, K.8
Yasumoto, K.9
-
18
-
-
78049385145
-
Association between lymphangiogenesis-/micrometastasis- and adhesion-related molecules in resected stage I NSCLC
-
in press
-
Yamashita T, Uramoto H, Onitsuka T, Ono K, Baba T, So T, So T, Takenoyama M, Hanagiri T, Oyama T, and Yasumoto K: Association between lymphangiogenesis-/micrometastasis- and adhesion-related molecules in resected stage I NSCLC. Lung Cancer, in press
-
Lung Cancer
-
-
Yamashita, T.1
Uramoto, H.2
Onitsuka, T.3
Ono, K.4
Baba, T.5
So, T.6
So, T.7
Takenoyama, M.8
Hanagiri, T.9
Oyama, T.10
Yasumoto, K.11
-
19
-
-
77950460014
-
Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status
-
Onitsuka T, Uramoto H, Nose N, Takenoyama M, Hanagiri T, Sugio K, and Yasumoto K: Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status. Lung Cancer 68: 198-203, 2010.
-
(2010)
Lung Cancer
, vol.68
, pp. 198-203
-
-
Onitsuka, T.1
Uramoto, H.2
Nose, N.3
Takenoyama, M.4
Hanagiri, T.5
Sugio, K.6
Yasumoto, K.7
-
20
-
-
35848963865
-
Predictive implications of nucleoside metabolizing enzymes in premenopausal women with node-positive primary breast cancer who were randomly assigned to receive tamoxifen alone or tamoxifen plus tegafur-uracil as adjuvant therapy
-
Toi M, Ikeda T, Akiyama F, Kurosumi M, Tsuda H, Sakamoto G, and Abe O: Predictive implications of nucleoside metabolizing enzymes in premenopausal women with node-positive primary breast cancer who were randomly assigned to receive tamoxifen alone or tamoxifen plus tegafur-uracil as adjuvant therapy. Int J Oncol 31: 899-906, 2007.
-
(2007)
Int J Oncol
, vol.31
, pp. 899-906
-
-
Toi, M.1
Ikeda, T.2
Akiyama, F.3
Kurosumi, M.4
Tsuda, H.5
Sakamoto, G.6
Abe, O.7
-
21
-
-
64049115311
-
The differential efficacy of pemetrexed according to NSCLC histology: A review of two Phase III studies
-
Scagliotti G, Hanna N, Fossella F, Sugarman K, Blatter J, Peterson P, Simms L, and Shepherd FA: The differential efficacy of pemetrexed according to NSCLC histology: a review of two Phase III studies. Oncologist 14: 253-263, 2009.
-
(2009)
Oncologist
, vol.14
, pp. 253-263
-
-
Scagliotti, G.1
Hanna, N.2
Fossella, F.3
Sugarman, K.4
Blatter, J.5
Peterson, P.6
Simms, L.7
Shepherd, F.A.8
-
22
-
-
77951894575
-
Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy
-
Righi L, Papotti MG, Ceppi P, Billè A, Bacillo E, Molinaro L, Ruffini E, Scagliotti GV, and Selvaggi G: Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy. J Clin Oncol 28: 1534-1539, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1534-1539
-
-
Righi, L.1
Papotti, M.G.2
Ceppi, P.3
Billè, A.4
Bacillo, E.5
Molinaro, L.6
Ruffini, E.7
Scagliotti, G.V.8
Selvaggi, G.9
-
23
-
-
70249137644
-
Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small cell lung cancer: A model for assessing population-related pharmacogenomics
-
Gandara DR, Kawaguchi T, Crowley J, Moon J, Furuse K, Kawahara M, Teramukai S, Ohe Y, Kubota K, Williamson SK, Gautschi O, Lenz HJ, McLeod HL, Lara PN Jr., Coltman CA Jr., Fukuoka M, Saijo N, Fukushima M, and Mack PC: Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small cell lung cancer: a model for assessing population-related pharmacogenomics. J Clin Oncol 27: 3540-3546, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3540-3546
-
-
Gandara, D.R.1
Kawaguchi, T.2
Crowley, J.3
Moon, J.4
Furuse, K.5
Kawahara, M.6
Teramukai, S.7
Ohe, Y.8
Kubota, K.9
Williamson, S.K.10
Gautschi, O.11
Lenz, H.J.12
McLeod, H.L.13
Lara Jr., P.N.14
Coltman Jr., C.A.15
Fukuoka, M.16
Saijo, N.17
Fukushima, M.18
Mack, P.C.19
-
24
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
West Japan Oncology Group
-
Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, Seto T, Satouchi M, Tada H, Hirashima T, Asami K, Katakami N, Takada M, Yoshioka H, Shibata K, Kudoh S, Shimizu E, Saito H, Toyooka S, Nakagawa K, and Fukuoka M; West Japan Oncology Group: Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 11: 121-128, 2010.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
Negoro, S.4
Okamoto, I.5
Tsurutani, J.6
Seto, T.7
Satouchi, M.8
Tada, H.9
Hirashima, T.10
Asami, K.11
Katakami, N.12
Takada, M.13
Yoshioka, H.14
Shibata, K.15
Kudoh, S.16
Shimizu, E.17
Saito, H.18
Toyooka, S.19
Nakagawa, K.20
Fukuoka, M.21
more..
-
25
-
-
33947434048
-
Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer?
-
Uramoto H, and Mitsudomi T: Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer? Br J Cancer 96: 857-863, 2007.
-
(2007)
Br J Cancer
, vol.96
, pp. 857-863
-
-
Uramoto, H.1
Mitsudomi, T.2
-
26
-
-
30644458252
-
Epidermal growth factor receptor mutations are associated with gefitinib sensitivity in non-small cell lung cancer in Japanese
-
Uramoto H, Sugio K, Oyama T, Ono K, Sugaya M, Yoshimatsu T, Hanagiri T, Morita M, and Yasumoto K: Epidermal growth factor receptor mutations are associated with gefitinib sensitivity in non-small cell lung cancer in Japanese. Lung Cancer 51: 71-77, 2006.
-
(2006)
Lung Cancer
, vol.51
, pp. 71-77
-
-
Uramoto, H.1
Sugio, K.2
Oyama, T.3
Ono, K.4
Sugaya, M.5
Yoshimatsu, T.6
Hanagiri, T.7
Morita, M.8
Yasumoto, K.9
-
27
-
-
34547922452
-
Targeting the function of the HER2 oncogene in human cancer therapeutics
-
Moasser MM: Targeting the function of the HER2 oncogene in human cancer therapeutics. Oncogene 26: 6577-6592, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 6577-6592
-
-
Moasser, M.M.1
-
28
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small cell lung cancer (FLEX): An open-label randomised phase III trial
-
FLEX Study Team
-
Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, Vynnychenko I, Park K, Yu CT, Ganul V, Roh JK, Bajetta E, O'Byrne K, de Marinis F, Eberhardt W, Goddemeier T, Emig M, and Gatzemeier U: FLEX Study Team. Cetuximab plus chemotherapy in patients with advanced non-small cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 373: 1525-1531, 2009.
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
Von Pawel, J.4
Krzakowski, M.5
Ramlau, R.6
Vynnychenko, I.7
Park, K.8
Yu, C.T.9
Ganul, V.10
Roh, J.K.11
Bajetta, E.12
O'Byrne, K.13
De Marinis, F.14
Eberhardt, W.15
Goddemeier, T.16
Emig, M.17
Gatzemeier, U.18
-
29
-
-
77950478885
-
Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
-
Robak T, Dmoszynska A, Solal-Céligny P, Warzocha K, Loscertales J, Catalano J, Afanasiev BV, Larratt L, Geisler CH, Montillo M, Zyuzgin I, Ganly PS, Dartigeas C, Rosta A, Maurer J, Mendila M, Saville MW, Valente N, Wenger MK, and Moiseev SI: Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol 28: 1756-1765, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1756-1765
-
-
Robak, T.1
Dmoszynska, A.2
Solal-Céligny, P.3
Warzocha, K.4
Loscertales, J.5
Catalano, J.6
Afanasiev, B.V.7
Larratt, L.8
Geisler, C.H.9
Montillo, M.10
Zyuzgin, I.11
Ganly, P.S.12
Dartigeas, C.13
Rosta, A.14
Maurer, J.15
Mendila, M.16
Saville, M.W.17
Valente, N.18
Wenger, M.K.19
Moiseev, S.I.20
more..
-
30
-
-
42949099359
-
Retreatment with pemetrexed-based chemotherapy in malignant pleural mesothelioma (MPM): A second-line treatment option
-
Razak AR, Chatten KJ, and Hughes AN: Retreatment with pemetrexed-based chemotherapy in malignant pleural mesothelioma (MPM): a second-line treatment option. Lung Cancer 60: 294-297, 2008.
-
(2008)
Lung Cancer
, vol.60
, pp. 294-297
-
-
Razak, A.R.1
Chatten, K.J.2
Hughes, A.N.3
|