Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome

Familial Cancer

Volumn 9, Issue 3, 2010, Pages 345-356

  Kwok, Chau To ^a,b   Ward, Robyn L ^a,b   Hawkins, Nicholas J ^a   Hitchins, Megan P ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Allelic expression; Colorectal cancer; Epimutation; Lynch syndrome; MLH1; Pyrosequencing; SNP

Indexed keywords

GENOMIC DNA; PROTEIN MLH1;

ALLELIC IMBALANCE; ARTICLE; CELL CULTURE; CELL IMMORTALIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE DELETION; GENE IDENTIFICATION; GENE LOSS; GENE MUTATION; GENETIC TRANSCRIPTION; GENOTYPE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOTE; HUMAN; HYPOTHESIS; INTRON; LYMPHOBLASTOID CELL; PRIORITY JOURNAL; PYROSEQUENCING; QUANTITATIVE ANALYSIS; RNA SPLICING; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELIC IMBALANCE; BASE SEQUENCE; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA METHYLATION; GENE EXPRESSION PROFILING; GERM-LINE MUTATION; HUMANS; LOSS OF HETEROZYGOSITY; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 78650231157     PISSN: 13899600     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10689-009-9314-0     Document Type: Article

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