Moving towards a cure: Blocking pathogenic antibodies in systemic lupus erythematosus

Journal of Internal Medicine

Volumn 269, Issue 1, 2011, Pages 36-44

  Diamond, B ^a   Bloom, O ^a   Al Abed, Y ^a   Kowal, C ^a   Huerta, P T ^b   Volpe, B T ^b  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Autoantibodies; Systemic lupus erythematosus; Therapeutic strategy

Indexed keywords

ANTIBODY; ANTIMALARIAL AGENT; AUTOANTIBODY; CORTICOSTEROID; CYTOTOXIC AGENT; DOUBLE STRANDED DNA ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT;

ANTIBODY SPECIFICITY; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONFERENCE PAPER; CROSS REACTION; HUMAN; IMMUNE DEFICIENCY; INFECTION; NONHUMAN; ORGAN INJURY; PATHOGENESIS; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TISSUE INJURY;

ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; DNA; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS VASCULITIS, CENTRAL NERVOUS SYSTEM; MICE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 78650221829     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2010.02318.x     Document Type: Conference Paper

References (43)

1. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-7.
2. Harrison MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725-8.
3. Lahita RG. The clinical presentations of systemic lupus erythematosus in adults. In Lahita RG, ed. Systemic Lupus Erythematosus, 4th edn. New York: Elsevier 2004; 435-84.
4. Rönnblom L. Potential role of IFN alpha in adult lupus. Arthritis Res Ther 2010; 12(Suppl 1): S3.
5. Hahn BH, Tsao BP. Antibodies to DNA. In Wallace DJ, Hahn BH, eds. Dubois' Lupus Erythematosus. Philadelphia, PA: Lippincott, Williams & Wilkins, 2002; 425-45.
6. Gaynor B, Putterman C, Valadon P, Spatz L, Scharff MD, Diamond B. Peptide inhibition of glomerular deposition of an anti-DNA antibody. Proc Natl Acad Sci USA 1997; 94: 1955-60.
7. DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 2001; 7: 1189-93.
8. Li Z, Woo CJ, Iglesias-Ussel MD, Ronai D, Scharff MD. The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes Dev 2004; 18: 1-11.
9. The American College of Rheumatology. Nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum 1999; 42: 599-608.
10. Garcia-Cavazos R, Brey R. Neuropsychiatric systemic lupus erythematosus. In Lahita RG, ed. Systemic Lupus Erythematosus, 4th edn. New York, USA: Elsevier 2004; 757-84.
11. Kozora E, Hanly JG, Lapteva L, Filley CM. Cognitive dysfunction in systemic lupus erythematosus: past, present, and future. Arthritis Rheum 2008; 58: 3286-98.
12. LeDoux JE. Emotion circuits in the brain. Annu Rev Neurosci 2000; 23: 155-84.
13. Diamond B, Huerta PT, Mina-Osorio P, Kowal C, Volpe BT. Losing your nerves? Maybe it's the antibodies Nat Rev Immunol 2009; 9: 449-56.
14. Faust TW, Chang EH, Kowal C et al. Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms. Proc Natl Acad Sci USA 2010; 107: 18569-74.
15. Kussius CL, Popescu GK. Kinetic basis of partial agonism at NMDA receptors. Nat Neurosci 2009; 12: 1114-20.
16. Schinder AF, Olson EC, Spitzer NC, Montal M. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci 1996; 16: 6125-33.
17. Kowal C, DeGiorgio LA, Nakaoka T et al. Cognition and immunity; antibody impairs memory. Immunity 2004; 21: 179-88.
18. Banks WA, Erickson MA. The blood-brain barrier and immune function and dysfunction. Neurobiol Dis 2010; 37: 26-32.
19. Kowal C, DeGiorgio LA, Lee JY et al. Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci USA 2006; 103: 19854-9.
20. Huerta PT, Kowal C, DeGiorgio LA, Volpe BT, Diamond B. Immunity and behavior: antibodies alter emotion. Proc Natl Acad Sci USA 2006; 103: 678-83.
21. Lahita RG. Systemic lupus erythematosus: learning disability in the male offspring of female patients and relationship to laterality. Psychoneuroendocrinology 1988; 13: 385-96.
22. Ross G, Sammaritano L, Nass R, Lockshin M. Effects of mothers' autoimmune disease during pregnancy on learning disabilities and hand preference in their children. Arch Pediatr Adolesc Med 2003; 157: 397-402.
23. Tincani A, Danieli E, Nuzzo M et al. Impact of in utero environment on the offspring of lupus patients. Lupus 2006; 15: 801-7.
24. Lee JY, Huerta PT, Zhang J et al. Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus. Nat Med 2009; 15: 91-6.
25. Komuro H, Rakic P. Modulation of neuronal migration by NMDA receptors. Science 1993; 260: 95-7.
26. Rakic P, Cameron RS, Komuro H. Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration. Curr Opin Neurobiol 1994; 4: 63-9.
27. Polleux F, Anton ES. Neuronal migration and the developing brain. In Rao MS, Jacobson M, eds. Developmental Neurobiology. New York, NY: Kluwer Academic/Plenum 2005; 230-9.
28. Deng W, Aimone JB, Gage FH. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 2010; 11: 339-50.
29. Neri F, Chimini L, Bonomi F et al. Neuropsychological development of children born to patients with systemic lupus erythematosus. Lupus 2004; 13: 805-11.
30. Lipton SA. Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation. Curr Drug Targets 2007; 8: 621-32.
31. Jones R, Sheehan B, Phillips P et al. DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT. Trials 2010; 10: 57.
32. Hanly JG, Fisk JD, Sherwood G, Jones E, Jones JV, Eastwood B. Cognitive impairment in patients with systemic lupus erythematosus. J Rheumatol 1992; 19: 562-7.
33. Brey RL, Holliday SL, Saklad AR et al. Neuropsychiatric syndromes in lupus: prevalence using standardized definitions. Neurology 2002; 58: 1214-20.
34. Lapteva L, Nowak M, Yarboro CH et al. Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus. Arthritis Rheum 2006; 54: 2505-14.
35. Omdal R, Brokstad K, Waterloo K, Koldingsnes W, Jonsson R, Mellgren SI. Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors. Eur J Neurol 2005; 12: 392-8.
36. Harrison MJ, Ravdin LD, Lockshin MD. Relationship between serum NR2a antibodies and cognitive dysfunction in systemic lupus erythematosus. Arthritis Rheum 2006; 54: 2515-22.
37. Hanly JG, Robichaud J, Fisk JD. Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosus. J Rheumatol 2006; 33: 1553-8.
38. Husebye ES, Sthoeger ZM, Dayan M et al. Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus. Ann Rheum Dis 2005; 64: 1210-3.
39. Yoshio T, Onda K, Nara H, Minota S. Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 2006; 54: 675-8.
40. Arinuma Y, Yanagida T, Hirohata S. Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 2008; 58: 1130-5.
41. Emmer BJ, van der Grond J, Steup-Beekman GM, Huizinga TW, van Buchem MA. Selective involvement of the amygdala in systemic lupus erythematosus. PLoS Med 2006; 3: e499.
42. Fragoso-Loyo H, Cabiedes J, Orozco-Narváez A et al. Serum and cerebrospinal fluid autoantibodies in patients with neuropsychiatric lupus erythematosus. Implications for diagnosis and pathogenesis. PLoS One 2008; 3: e3347.
43. Sharma A, Isenberg D, Diamond B. Studies of human polyclonal and monoclonal antibodies binding to lupus autoantigens and cross-reactive antigens. Rheumatology 2003; 42: 453-63.