Design and synthesis of novel 5,6-bisindolylpyrimidin-4-ones structurally related to ruboxistaurin (LY333531)

Tetrahedron

Volumn 66, Issue 51, 2010, Pages 9754-9761

  Pierce, Larry T ^a   Cahill, Michael M ^a   McCarthy, Florence O ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Bisindolylmaleimides; Bisindolylpyrimidines; Kinase inhibition; Oxidative desulfurisation; Uracil formation

Indexed keywords

2 AMINO 5,6 BIS(1 METHYL 1H INDOL 3 YL)PYRIMIDIN 4(3H) ONE; 5,6 BIS(1 METHYL 1H INDOL 3 YL) 2 (METHYLTHIO)PYRIMIDIN 4 (3H)ONE; 5,6 BIS(1 METHYL 1H INDOL 3 YL) 2 THIOXO 2,3 DIHYDROPYRIMIDIN 4(1H) ONE; 5,6 BIS(1 METHYL 1H INDOL 3 YL) 2 THIOXO 2,3 DIHYDROPYRIMIDIN 4(1H)ONE; 5,6 BIS(1 METHYL 1H INDOL 3 YL)PYRIMIDIN 4(3H) ONE; 5,6 BIS(1 METHYL 1H INDOL 3 YL)PYRIMIDINE 2,4(1H,3H) DIONE; 6,7 BIS(1 METHYL 1H INDOL 3 YL) 2H THIAZOLO[3,2 A]PYRIMIDIN 5(3H) ONE; AMIDINE; GUANIDINE DERIVATIVE; NUCLEOPHILE; PYRIMIDINONE DERIVATIVE; RUBOXISTAURIN; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; DESULFURIZATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL;

EID: 78650220469     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.10.020     Document Type: Article

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