Separation and characterization of forced degradation products of abacavir sulphate by LC-MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 2, 2011, Pages 279-285

  Rao, Nageswara R ^a   Vali, Mastan R ^a   Ramachandra, Bondigalla ^a   Raju, Satyanarayana S ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Abacavir sulphate; Antiretrovirals; Forced degradation; Kinetic behavior; LC MS MS

Indexed keywords

ABACAVIR; ACETONITRILE; AMMONIUM ACETATE;

ARTICLE; DRUG DEGRADATION; ELUTION; FRAGMENTATION REACTION; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PHOTOLYSIS; PRIORITY JOURNAL; TEMPERATURE STRESS;

CHROMATOGRAPHY, LIQUID; DIDEOXYNUCLEOSIDES; GUIDELINES AS TOPIC; HOT TEMPERATURE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INTERNATIONAL COOPERATION; KINETICS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PHOTOLYSIS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE INHIBITORS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 78650212391     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.08.021     Document Type: Article

References (22)

1. Gallant J.E. Initial therapy of HIV infection. J. Clin. Virol. 2002, 25:317-333.
2. Stefania N., Alessio B., Giuseppe I., Pasaqale N. Simultaneous determination of 16 anti-HIV drugs in human plasma by high-performance liquid chromatography. J. Chromatogr. B 2006, 831:258-266.
3. Elisabete A.P., Gustavo A.M., Marina F.M.T. Determination of antiretroviral agents in human serum by capillary electrophoresis. J. Chromatogr. A 2005, 1091:169-176.
4. Verweji-van C.P.W.G.M.W., Aarnoutse R.E., Burger D.M. Simultaneous determination of the HIV nucleoside analogue reverse transcriptase inhibitors lamivudine, didanosine, stavudine, zidovudine and abacavir in human plasma by reversed phase high performance liquid chromatography. J. Chromatogr. B 2005, 816:121-129.
5. Naser L.R., Richard R.T., Kashuba D.M. Simultaneous determination of six HIV nucleoside analogue reverse transcriptase inhibitors and nevirapine by liquid chromatography with ultraviolet absorbance detection. J. Chromatogr. B 2003, 791:137-147.
6. Joshua R.R., Caroline G.M. High-performance liquid chromatographic assay for abacavir and its two major metabolites in human urine and cerebrospinal fluid. J. Chromatogr. B 2001, 762:165-173.
7. Aymard G., Legrand M., Trichereau N., Diquet B. Determination of twelve antiretroviral agents in human plasma sample using reversed-phase high-performance liquid chromatography. J. Chromatogr. B 2000, 744:227-240.
8. Agnes I.V., Rolf W.S., Richard M.W.H., Jos H.B. Quantitative determination of abacavir (1592U89), a novel nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. B 1999, 736:123-128.
9. Yalcin O., Ayhan S., Sibel A.O. Simple and reliable HPLC method of abacavir determination in pharmaceuticals, human serum and drug dissolution studies from tablets. J. Liq. Chromatogr. Relat. Technol. 2005, 28:423-437.
10. Salut M.F., Pilar M., Cecilia F.L., Eduardo L.M. Determination of abacavir in human plasma by high-performance liquid chromatography with ultraviolet detection and the analytical error function. Biomed. Chromatogr. 2004, 18:862-865.
11. Severine C., Dimitri S., Mikael L., Alian P. Development and validation of a liquid chromatographic/tandem mass spectrometric assay for the quantitation of nucleoside HIV reverse transcriptase inhibitors in biological matrices. J. Mass. Spectrom. 2005, 40:9-18.
12. Seshachalam U., Haribabu B., Chandrasekhar K.B. Development and validation of a reverse-phase liquid chromatographic method for assay and related substances of abacavir sulfate. J. Sep. Sci. 2007, 30:28-34.
13. http//www.who.int/medicines/publications/pharmacopia/index.html.
14. Wu Y. The use of liquid chromatography-mass spectrometry for the identification of drug degradation products in pharmaceutical formulations. Biomed. Chromatogr. 2000, 14:384-396.
15. 2).
16. Boccardi G. Oxidative susceptibility testing. Pharmaceutical Stress Testing Predicting Drug Degradation 2005, Taylor & Francis, Boca Raton, FL, pp. 205-234. S.W. Baertschi (Ed.).
17. n. J. Pharm. Biomed. Anal. 2009, 49:55-63.
18. Ming Q., Shuo Y., Hong W., Majumdar P., Leigh N., Glaser R. Ammonia elimination from protonated nucleobases and related synthetic substrates. J. Am. Soc. Mass Spectrom. 2007, 18:2040-2057.
19. Calza P., Medana C., Francesco V., Giancotti C., Baiocchi Characterization of intermediate compounds formed upon photoinduced degradation of quinolones by high-performance liquid chromatography/high-resolution multiple-stage mass spectrometry. Rapid Commun. Mass spectrom. 2008, 22:1533-1552.
20. Rice J.M., Dudek G.O. Mass spectra of nucleic acid derivatives. II. Guanine, adenine, and related compounds. J. Am. Chem. Soc. 1967, 89:2719-2726.
21. Stevens M.A., Magrath D.I., Smith H.W., Brown G.B. Purine N-oxides. I. Mono-oxides of amino purines. J. Am. Chem. Soc. 1958, 85:2755-2758.
22. Stevens M.A., Brown G.B. Purine N-oxides. II. The structure of adenine n-oxide. J. Am. Chem. Soc. 1958, 85:2759-2762.