Study of forced decomposition behavior of lamivudine using LC, LC-MS/TOF and MSn

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 1, 2009, Pages 55-63

  Bedse, Gaurav ^a   Kumar, Vijay ^a   Singh, Saranjit ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Degradation pathway; Lamivudine; LC MS TOF; Mechanism; MSn; Stability indicating assay method; Stress studies

Indexed keywords

LAMIVUDINE;

ACIDITY; ALKALINITY; ARTICLE; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIGHT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PHOTOLYSIS; PRIORITY JOURNAL; TEMPERATURE STRESS; TIME OF FLIGHT MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; DRUG STABILITY; GUIDELINES AS TOPIC; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LAMIVUDINE; LIGHT; MASS SPECTROMETRY; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOTOLYSIS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE INHIBITORS; SENSITIVITY AND SPECIFICITY;

EID: 58649109150     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.10.002     Document Type: Article

References (21)

1. Coates J.A., Cammack N., Jenkinson H.J., Jowett A.J., Jowett M.I., Pearson B.A., Penn C.R., Rouse P.L., Viner K.C., and Cameron J.M. Antimicrob. Agents Chemother. 36 (1992) 733-739
2. Pluda J.M., Cooley T.P., Montaner J.S., Shay L.E., Reinhalter N.E., Warthan S.N., Ruedy J., Hirst H.M., Vicary C.A., and Quinn J.B. J. Infect. Dis. 171 (1995) 1438-1447
3. Ohta Y., and Shinkai I. Bioorg. Med. Chem. 5 (1997) 639-640
4. Kamiya N. J. Antimicrob. Chemother. 51 (2003) 1085-1089
5. Alnouti Y., White C.A., and Bartlett M.G. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 803 (2004) 279-284
6. Kano E.K., Serra C.H.D.R., Koono E.E.M., Andrade S.S., and Porta V. Int. J. Pharm. 297 (2005) 73-79
7. Hoetelmans R.M.W., Profijt M., Meenhorst P.L., Mulder J.W., and Beijnen J.H. J. Chromatogr. B: Analyt. Technol. Biomed. Sci. Appl. 713 (1998) 387-394
8. Robbins B.L., Poston P.A., Neal E.F., Slaughter C., and Rodman J.H. J. Chromatogr. B: Analyt. Technol. Biomed. Sci. Appl. 850 (2007) 310-317
9. Plumb R.S., Gray R.D.M., Harker A.J., and Taylor S. J. Chromatogr. B: Analyt. Technol. Biomed. Sci. Appl. 687 (1996) 457-461
10. Kaul N., Agrawal H., Paradkar A.R., and Mahadik K.R. Chromatographia 60 (2004) 213-221
11. http://www.who.int/medicines/publications/pharmacopoeia/QAS_124rev 2_Lamivudine.monoFINAL.pdf.
12. ICH, Q1A(R2), in: International Conference on Harmonisation, IFPMA, Geneva, 2003.
13. WHO, Draft Stability Testing of Active Pharmaceutical Ingredients and Pharmaceutical Products, World Health Organization, Geneva, 2007.
14. ICH, Q1B, in: International Conference on Harmonisation, IFPMA, Geneva, 1996.
15. ICH, Q2(R1), in: International Conference on Harmonisation, IFPMA, Geneva, 2005.
16. Qian M., Yang S., Wu H., Majumdar P., Leigh N., and Glaser R. J. Am. Soc. Mass Spectrom. 18 (2007) 2040-2057
17. Cao H., and Wang Y. J. Am. Soc. Mass Spectrom. 17 (2006) 1335-1341
18. Font E., Lasanta S., Rosario O., and Rodriguez J.F. Nucleosides Nucleotides 17 (1998) 845-853
19. Pogocki D., and Schoeneich C. J. Pharm. Sci. 89 (2000) 443-456
20. Dunge A., Chakraborti A.K., and Singh S. J. Pharm. Biomed. Anal. 35 (2004) 965-970
21. Rozwadowska M.D., and Sulima A. Tetrahedron 59 (2003) 1173-1179