No association between the KCNH1, KCNJ10 and KCNN3 genes and schizophrenia in the Han Chinese population

Neuroscience Letters

Volumn 487, Issue 1, 2011, Pages 61-65

  shen, Qi ^a,c   Zhang, Jing ^a,c   Wang, Yang ^a,c   Liu, Baocheng ^a,c   Li, Xingwang ^a,b,c   Zhao, Qingzhu ^a,c   Chen, Shiqing ^a,c   Ji, Jue ^a,c   Yang, Fengping ^a,c   Wan, Chunling ^a,c   Gao, Linghan ^a,c   Xu, Yifeng ^d   Feng, Guoyin ^d   He, Lin ^a,b,c   He, Guang ^a,c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c Chinese Academy of Sciences   (China)

^d SHANGHAI MENTAL HEALTH CENTER   (China)

Author keywords

Han Chinese population; Potassium channels; Schizophrenia

Indexed keywords

KCNH1 PROTEIN; KCNJ10 PROTEIN; KCNN3 PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ADULT; ARTICLE; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SCHIZOPHRENIA; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 78650194080     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.09.074     Document Type: Article

References (33)

1. Barrett J.C, Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
2. Blank T., Nijholt I., Kye M.J., Radulovic J., Spiess J. Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits. Nat. Neurosci. 2003, 6:911-912.
3. Bond C.T., Pessia M., Xia X.M., Lagrutta A., Kavanaugh M.P., Adelman J.P. Cloning and expression of a family of inward rectifier potassium channels. Receptors Channels 1994, 2:183-191.
4. Bowen T., Guy C.A., Craddock N., Cardno A.G., Williams N.M., Spurlock G., Murphy K.C., Jones L.A., Gray M., Sanders R.D., McCarthy G., Chandy K.G., Fantino E., Kalman K., Gutman G.A., Gargus J.J., Williams J., McGuffin P., Owen M.J., O'Donovan M.C. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Mol. Psychiatry 1998, 3:266-269.
5. Braff D.L., Light G.A. The use of neurophysiological endophenotypes to understand the genetic basis of schizophrenia. Dialogues Clin. Neurosci. 2005, 7:125-135.
6. Braff D.L., Swerdlow N.R., Geyer M.A. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. Am. J. Psychiatry 1999, 156:596-602.
7. Browne D.L., Gancher S.T., Nutt J.G., Brunt E.R., Smith E.A., Kramer P., Litt M. Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nat. Genet. 1994, 8:136-140.
8. Brzustowicz L.M., Hodgkinson K.A., Chow E.W., Honer W.G., Bassett A.S. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 2000, 288:678-682.
9. Buono R.J., Lohoff F.W., Sander T., Sperling M.R., O'Connor M.J., Dlugos D.J., Ryan S.G., Golden G.T., Zhao H., Scattergood T.M., Berrettini W.H., Ferraro T.N. Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility. Epilepsy Res. 2004, 58:175-183.
10. Chandy K.G., Fantino E., Wittekindt O., Kalman K., Tong L.L., Ho T.H., Gutman G.A., Crocq M.A., Ganguli R., Nimgaonkar V., Morris-Rosendahl D.J., Gargus J.J. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?. Mol. Psychiatry 1998, 3:32-37.
11. Djukic B., Casper K.B., Philpot B.D., Chin L.S., McCarthy K.D. Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. J. Neurosci. 2007, 27:11354-11365.
12. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 2003, 25:115-121.
13. Faul F., Erdfelder E., Lang A.G., Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 2007, 39:175-191.
14. Guo W, Li H., Aimond F., Johns D.C., Rhodes K.J., Trimmer J.S., Nerbonne J.M. Role of heteromultimers in the generation of myocardial transient outward K+ currents. Circ. Res. 2002, 90:586-593.
15. Hahn L.W, Ritchie M.D., Moore J.H. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 2003, 19:376-382.
16. Heuser K., Nagelhus E.A., Tauboll E., Indahl U., Berg P.R., Lien S., Nakken S., Gjerstad L., Ottersen O.P. Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. Epilepsy Res. 2009, 88:55-64.
17. Jacobsen J.P., Weikop P., Hansen H.H., Mikkelsen J.D., Redrobe J.P., Holst D., Bond C.T., Adelman J.P., Christophersen P., Mirza N.R. SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors. Genes Brain Behav. 2008, 7:836-848.
18. Jeon Y.W., Polich J. Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. Psychophysiology 2003, 40:684-701.
19. Li T, Hu X., Chandy K.G., Fantino E., Kalman K., Gutman G., Gargus J.J., Freeman B., Murray R.M., Dawson E., Liu X., Bruinvels A.T., Sham P.C., Collier D.A. Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia. Biochem. Biophys. Res. Commun. 1998, 251:662-665.
20. Martin S., Lino de Oliveira C., Mello de Queiroz F., Pardo L.A., Stuhmer W., Del Bel E. Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. Neuroscience 2008, 155:833-844.
21. Neusch C., Rozengurt N., Jacobs R.E., Lester H.A., Kofuji P. Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. J. Neurosci. 2001, 21:5429-5438.
22. Pineda R.H., Knoeckel C.S., Taylor A.D., Estrada-Bernal A., Ribera A.B. Kv1 potassium channel complexes in vivo require Kvbeta2 subunits in dorsal spinal neurons. J. Neurophysiol. 2008, 100:2125-2136.
23. Potter D, Summerfelt A., Gold J., Buchanan R.W. Review of clinical correlates of P50 sensory gating abnormalities in patients with schizophrenia. Schizophr. Bull. 2006, 32:692-700.
24. Robbins J. KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol. Ther. 2001, 90:1-19.
25. Saha S., Chant D., Welham J., McGrath J. A systematic review of the prevalence of schizophrenia. PLoS Med. 2005, 2:e141.
26. Sailer C.A., Hu H., Kaufmann W.A., Trieb M., Schwarzer C., Storm J.F., Knaus H.G. Regional differences in distribution and functional expression of small-conductance Ca2+-activated K+ channels in rat brain. J. Neurosci. 2002, 22:9698-9707.
27. Q. Saleem, V.S. Sreevidya, J. Sudhir, J.V. Savithri, Y. Gowda, C. B-Rao, V. Benegal, P.P. Majumder, A. Anand, S.K. Brahmachari, S. Jain, Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia, Am. J. Med. Genet. 96 (2000) 744-748.
28. Shi Y.Y., He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005, 15:97-98.
29. Tai Y., Feng S., Du W., Wang Y. Functional roles of TRPC channels in the developing brain. Pflugers Arch. 2009, 458:283-289.
30. Ujike H., Yamamoto A., Tanaka Y., Takehisa Y., Takaki M., Taked T., Kodama M., Kuroda S. Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder. Psychiatry Res. 2001, 101:203-207.
31. Van Horn J.D., McManus I.C. Ventricular enlargement in schizophrenia. A meta-analysis of studies of the ventricle:brain ratio (VBR). Br. J. Psychiatry 1992, 160:687-697.
32. Wassef A., Baker J., Kochan L.D. GABA and schizophrenia: a review of basic science and clinical studies. J. Clin. Psychopharmacol. 2003, 23:601-640.
33. Wu C.F., Ganetzky B., Haugland F.N., Liu A.X. Potassium currents in Drosophila: different components affected by mutations of two genes. Science 1983, 220:1076-1078.