Sensitive and rapid HPLC method for determination of memantine in human plasma using OPA derivatization and fluorescence detection: Application to pharmacokinetic studies

Scientia Pharmaceutica

Volumn 78, Issue 4, 2010, Pages 847-856

  Zarghi, Afshin ^a   Shafaati, Alireza ^a   Foroutan, Seyed Mohsen ^a   Khoddam, Arash ^b   Madadian, Babak ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Noor Research and Educational Institute   (Iran)

Author keywords

Derivatization; HPLC; Memantine; Monolithic column; Pharmacokinetic study

Indexed keywords

AMANTADINE; MEMANTINE; PHTHALALDEHYDE;

AREA UNDER THE CURVE; ARTICLE; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG MONITORING; DRUG STRUCTURE; ELUTION; FLOW RATE; FLUORESCENCE ANALYSIS; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; SPECTRAL SENSITIVITY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 78650190720     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.1008-17     Document Type: Article

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