메뉴 건너뛰기




Volumn 46, Issue 7, 2007, Pages 599-612

Memantine pharmacotherapy: A naturalistic study using a population pharmacokinetic approach

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B6; MEMANTINE;

EID: 34347377858     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200746070-00005     Document Type: Article
Times cited : (53)

References (44)
  • 1
    • 0028170903 scopus 로고
    • Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties
    • Kornhuber J, Weller M, Schoppmeyer K, et al. Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J Neural Transm Suppl 1994; 43: 91-104
    • (1994) J Neural Transm Suppl , vol.43 , pp. 91-104
    • Kornhuber, J.1    Weller, M.2    Schoppmeyer, K.3
  • 2
    • 4644368367 scopus 로고    scopus 로고
    • Memantine hydrochloride: Pharmacological and clinical profile
    • Möbius HJ, Stöffler A, Graham SM. Memantine hydrochloride: pharmacological and clinical profile. Drugs Today (Barc) 2004; 40 (8): 685-95
    • (2004) Drugs Today (Barc) , vol.40 , Issue.8 , pp. 685-695
    • Möbius, H.J.1    Stöffler, A.2    Graham, S.M.3
  • 3
    • 0024472706 scopus 로고
    • 3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex
    • 3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex. Eur J Pharmacol 1989; 166: 589-90
    • (1989) Eur J Pharmacol , vol.166 , pp. 589-590
    • Kornhuber, J.1    Bormann, J.2    Retz, W.3
  • 4
    • 0024344256 scopus 로고
    • Memantine is a potent blocker of N-methyl-D-Bayesian aspartate (NMDA) receptor channels
    • Bormann J. Memantine is a potent blocker of N-methyl-D-Bayesian aspartate (NMDA) receptor channels. Eur J Pharmacol 1989; 166: 591-2
    • (1989) Eur J Pharmacol , vol.166 , pp. 591-592
    • Bormann, J.1
  • 5
    • 0025801041 scopus 로고
    • Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: A human postmortem brain study
    • Kornhuber J, Bormann J, Hübers M, et al. Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study. Eur J Pharmacol Mol Pharmacol Sect 1991; 206: 297-300
    • (1991) Eur J Pharmacol Mol Pharmacol Sect , vol.206 , pp. 297-300
    • Kornhuber, J.1    Bormann, J.2    Hübers, M.3
  • 6
    • 0029085113 scopus 로고
    • Cerebrospinal fluid and serum concentrations of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine in man
    • Kornhuber J, Quack G. Cerebrospinal fluid and serum concentrations of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine in man. Neurosci Lett 1995; 195: 137-9
    • (1995) Neurosci Lett , vol.195 , pp. 137-139
    • Kornhuber, J.1    Quack, G.2
  • 7
    • 37249007168 scopus 로고    scopus 로고
    • European Medicines Agency EMEA, European public assessment report [online, Available from URL:, Accessed May 18
    • European Medicines Agency (EMEA). EPARs for authorised medicinal products for human use: Axura. European public assessment report [online]. Available from URL: http://www.emea.europa.eu/humandocs/Humans/EPAR/axura/axura.htm [Accessed 2007 May 18]
    • (2007) EPARs for authorised medicinal products for human use: Axura
  • 8
    • 34347369138 scopus 로고    scopus 로고
    • European Medicines Agency EMEA, online, Available from URL:, Accessed May 18
    • European Medicines Agency (EMEA). Initial scientific discussion for the approval of Axura [online]. Available from URL: http://www.emea.europa.eu/ humandocs/PDFs/EPAR/axura/094802en6.pdf [Accessed 2007 May 18]
    • (2007) Initial scientific discussion for the approval of Axura
  • 10
    • 30344477961 scopus 로고    scopus 로고
    • Pharmacokinetic study of memantine in healthy and renally impaired subjects
    • Periclou A, Ventura D, Rao N, et al. Pharmacokinetic study of memantine in healthy and renally impaired subjects. Clin Pharmacol Ther 2006; 79 (1): 134-43
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.1 , pp. 134-143
    • Periclou, A.1    Ventura, D.2    Rao, N.3
  • 12
    • 0031783078 scopus 로고    scopus 로고
    • Influence of urine pH and urinary flow on the renal excretion of memantine
    • Freudenthaler S, Meineke I, Schreeb KH, et al. Influence of urine pH and urinary flow on the renal excretion of memantine. Br J Clin Pharmacol 1998; 46 (6): 541-6
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.6 , pp. 541-546
    • Freudenthaler, S.1    Meineke, I.2    Schreeb, K.H.3
  • 13
    • 0020075396 scopus 로고
    • Structure-anti-Parkinson activity relationships in the aminoadamantanes: Influence of bridgehead subin stitution
    • Henkel JG, Hane JT. Structure-anti-Parkinson activity relationships in the aminoadamantanes: influence of bridgehead subin stitution. J Med Chem 1982; 25: 51-6
    • (1982) J Med Chem , vol.25 , pp. 51-56
    • Henkel, J.G.1    Hane, J.T.2
  • 14
    • 8744295736 scopus 로고    scopus 로고
    • Inhibitory effects of memantine on human cytochrome P450 activities: Prediction of in vivo drug interactions
    • Micuda S, Mundlova L, Anzenbacherova E, et al. Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions. Eur J Clin Pharmacol 2004; 60: 583-9
    • (2004) Eur J Clin Pharmacol , vol.60 , pp. 583-589
    • Micuda, S.1    Mundlova, L.2    Anzenbacherova, E.3
  • 15
    • 0025836658 scopus 로고
    • Population pharmacokinetics: Theory and practice
    • Aarons L. Population pharmacokinetics: theory and practice. Br J Clin Pharmacol 1991; 32: 669-70
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 669-670
    • Aarons, L.1
  • 16
    • 0003747347 scopus 로고
    • NONMEM Project Group, San Francisco. San Francisco CA, University of California
    • Beal SL, Sheiner LB. NONMEM users guides, NONMEM Project Group, San Francisco. San Francisco (CA): University of California, 1992
    • (1992) NONMEM users guides
    • Beal, S.L.1    Sheiner, L.B.2
  • 17
    • 34347375113 scopus 로고    scopus 로고
    • FachInfo-Service, Deutschland, RoteListe Service GmbH, Frankfurt/Main [online, Available from URL:, Accessed Jan 15
    • FachInfo-Service. Fachinformationsverzeichnis Deutschland, RoteListe Service GmbH - Frankfurt/Main [online]. Available from URL: http://www.fachinfo. de [Accessed 2006 Jan 15]
    • (2006) Fachinformationsverzeichnis
  • 18
    • 0035209269 scopus 로고    scopus 로고
    • Mechanisms and clinical implications of renal drug excretion
    • Masereeuw R, Russel FG. Mechanisms and clinical implications of renal drug excretion. Drug Metab Rev 2001; 33 (3-4): 299-351
    • (2001) Drug Metab Rev , vol.33 , Issue.3-4 , pp. 299-351
    • Masereeuw, R.1    Russel, F.G.2
  • 20
    • 34347402267 scopus 로고    scopus 로고
    • Merz + Co. Validation of a GC/MS-method for the quantitative assessment of memantine in human plasma and urine [internal report]. Frankfurt/Main: Merz + Co., 2001
    • Merz + Co. Validation of a GC/MS-method for the quantitative assessment of memantine in human plasma and urine [internal report]. Frankfurt/Main: Merz + Co., 2001
  • 21
    • 0020359255 scopus 로고
    • Bayesian individualization of pharmacokinetics: Simple implementation and comparison with non-Bayesian methods
    • Sheiner LB, Beal SL. Bayesian individualization of pharmacokinetics: simple implementation and comparison with non-Bayesian methods. J Pharm Sci 1982; 71: 1344-8
    • (1982) J Pharm Sci , vol.71 , pp. 1344-1348
    • Sheiner, L.B.1    Beal, S.L.2
  • 22
    • 84972488102 scopus 로고
    • Generalized additive models
    • Hastie T, Tibshirani R. Generalized additive models. Stat Sci 1986; 1: 297-318
    • (1986) Stat Sci , vol.1 , pp. 297-318
    • Hastie, T.1    Tibshirani, R.2
  • 23
    • 0029363581 scopus 로고
    • Generalized additive models for medical research
    • Hastie T, Tibshirani R. Generalized additive models for medical research. Stat Methods Med Res 1995; 4 (3): 187-96
    • (1995) Stat Methods Med Res , vol.4 , Issue.3 , pp. 187-196
    • Hastie, T.1    Tibshirani, R.2
  • 24
    • 0026343643 scopus 로고
    • A three-step approach combining Bayesian regression and NONMEM population analysis: Application to midazolam
    • Maitre PO, Buhrer M, Thomson D, et al. A three-step approach combining Bayesian regression and NONMEM population analysis: application to midazolam. J Pharmacokinet Biopharm 1991; 19 (4): 377-84
    • (1991) J Pharmacokinet Biopharm , vol.19 , Issue.4 , pp. 377-384
    • Maitre, P.O.1    Buhrer, M.2    Thomson, D.3
  • 25
    • 0027049043 scopus 로고
    • Building population pharmacokinetic-pharmacodynamic models I: Models for covariate effects
    • Mandema JW, Verotta D, Sheiner LB. Building population pharmacokinetic-pharmacodynamic models I: models for covariate effects. J Pharmacokinet Biopharm 1992; 20 (5): 511-28
    • (1992) J Pharmacokinet Biopharm , vol.20 , Issue.5 , pp. 511-528
    • Mandema, J.W.1    Verotta, D.2    Sheiner, L.B.3
  • 26
    • 85046914570 scopus 로고    scopus 로고
    • Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis
    • Wählby U, Jonsson EN, Karlsson MO. Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis. AAPS PharmSci 2002; 4 (E27): 1-12
    • (2002) AAPS PharmSci , vol.4 , Issue.E27 , pp. 1-12
    • Wählby, U.1    Jonsson, E.N.2    Karlsson, M.O.3
  • 27
    • 14644405267 scopus 로고    scopus 로고
    • R Development Core Team, online, Available from URL:, Accessed Jan 15
    • R Development Core Team, R Development Core Team. The comprehensive R archive network [online]. Available from URL: http://cran.r-project.org/ [Accessed 2006 Jan 15]
    • (2006) The comprehensive R archive network
    • Development Core Team, R.1
  • 28
    • 0016355478 scopus 로고
    • A new look at the statistical model identification
    • Akaike H. A new look at the statistical model identification. IEEE Trans Autom Contr 1974; 19: 716-23
    • (1974) IEEE Trans Autom Contr , vol.19 , pp. 716-723
    • Akaike, H.1
  • 29
    • 0038586446 scopus 로고    scopus 로고
    • The kidney: The body's playground for drugs: an overview of renal drug handling with selected clinical correlates
    • Perri D, Ito S, Rowsell V, et al. The kidney: the body's playground for drugs: an overview of renal drug handling with selected clinical correlates. Can J Clin Pharmacol 2003; 10 (1): 17-23
    • (2003) Can J Clin Pharmacol , vol.10 , Issue.1 , pp. 17-23
    • Perri, D.1    Ito, S.2    Rowsell, V.3
  • 30
    • 0023129704 scopus 로고
    • Drug inhibition of penicillin tubular secretion: Concordance between in vitro and clinical findings
    • Nierenberg DW. Drug inhibition of penicillin tubular secretion: concordance between in vitro and clinical findings. J Pharmacol Exp Ther 1987; 240 (3): 712-6
    • (1987) J Pharmacol Exp Ther , vol.240 , Issue.3 , pp. 712-716
    • Nierenberg, D.W.1
  • 31
    • 0023204364 scopus 로고
    • Reduction of metformin renal tubular secretion by cimetidine in man
    • Somogyi A, Stockley C, Keal J, et al. Reduction of metformin renal tubular secretion by cimetidine in man. Br J Clin Pharmacol 1987; 23 (5): 545-51
    • (1987) Br J Clin Pharmacol , vol.23 , Issue.5 , pp. 545-551
    • Somogyi, A.1    Stockley, C.2    Keal, J.3
  • 32
    • 33645220096 scopus 로고    scopus 로고
    • Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants
    • Fujita T, Urban TJ, Leabman MK, et al. Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. J Pharm Sci 2006; 95 (1): 25-36
    • (2006) J Pharm Sci , vol.95 , Issue.1 , pp. 25-36
    • Fujita, T.1    Urban, T.J.2    Leabman, M.K.3
  • 33
    • 0027197696 scopus 로고
    • Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine
    • Gaudry SE, Sitar DS, Smyth DD, et al. Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine. Clin Pharmacol Ther 1993; 54 (1): 23-7
    • (1993) Clin Pharmacol Ther , vol.54 , Issue.1 , pp. 23-27
    • Gaudry, S.E.1    Sitar, D.S.2    Smyth, D.D.3
  • 34
    • 0031824347 scopus 로고    scopus 로고
    • Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine
    • Busch AE, Karbach U, Miska D, et al. Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol 1998; 54 (2): 342-52
    • (1998) Mol Pharmacol , vol.54 , Issue.2 , pp. 342-352
    • Busch, A.E.1    Karbach, U.2    Miska, D.3
  • 35
    • 0037183711 scopus 로고    scopus 로고
    • NMDA receptor antagonists to characterize rat renal organic cation transporter function
    • Fourie J, Escobar MR, Sitar DS. NMDA receptor antagonists to characterize rat renal organic cation transporter function. Eur J Pharmacol 2002; 452 (1): 1-10
    • (2002) Eur J Pharmacol , vol.452 , Issue.1 , pp. 1-10
    • Fourie, J.1    Escobar, M.R.2    Sitar, D.S.3
  • 37
    • 0242552872 scopus 로고    scopus 로고
    • Importance of P-glycoprotein for drug disposition in humans
    • Fromm MF. Importance of P-glycoprotein for drug disposition in humans. Eur J Clin Invest 2003; 33 Suppl. 2: 6-9
    • (2003) Eur J Clin Invest , vol.33 , Issue.SUPPL. 2 , pp. 6-9
    • Fromm, M.F.1
  • 38
    • 4143051189 scopus 로고    scopus 로고
    • Lack of pharmacokinetic or pharmacodynamic interaction between memantine and donepezil
    • Periclou AP, Ventura D, Sherman T, et al. Lack of pharmacokinetic or pharmacodynamic interaction between memantine and donepezil. Ann Pharmacother 2004; 38 (9): 1389-94
    • (2004) Ann Pharmacother , vol.38 , Issue.9 , pp. 1389-1394
    • Periclou, A.P.1    Ventura, D.2    Sherman, T.3
  • 39
    • 28444473045 scopus 로고    scopus 로고
    • Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: A single-center, multiple-dose, open-label study
    • Rao N, Chou T, Ventura D, et al. Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: a single-center, multiple-dose, open-label study. Clin Ther 2005; 27 (10): 1596-606
    • (2005) Clin Ther , vol.27 , Issue.10 , pp. 1596-1606
    • Rao, N.1    Chou, T.2    Ventura, D.3
  • 40
    • 8844254692 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics and safety of donepezil HCl in subjects with moderately impaired renal function
    • Nagy CF, Kumar D, Cullen EI, et al. Steady-state pharmacokinetics and safety of donepezil HCl in subjects with moderately impaired renal function. Br J Clin Pharmacol 2004; 58 Suppl. 1: 18-24
    • (2004) Br J Clin Pharmacol , vol.58 , Issue.SUPPL. 1 , pp. 18-24
    • Nagy, C.F.1    Kumar, D.2    Cullen, E.I.3
  • 41
    • 0032420657 scopus 로고    scopus 로고
    • An evaluation of the pharmacokinetics of donepezil HCl in patients with moderately to severely impaired renal function
    • Tiseo PJ, Foley K, Friedhoff LT. An evaluation of the pharmacokinetics of donepezil HCl in patients with moderately to severely impaired renal function. Br J Clin Pharmacol 1998; 46 Suppl. 1: 56-60
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 56-60
    • Tiseo, P.J.1    Foley, K.2    Friedhoff, L.T.3
  • 42
    • 0027380851 scopus 로고
    • Evidence for lysosomotropism of memantine in cultured human cells: Cellular kinetics and effects of memantine on phospholipid content and composition, membrane fluidity and β-adrenergic transmission
    • Honegger UE, Quack G, Wiesmann UN. Evidence for lysosomotropism of memantine in cultured human cells: cellular kinetics and effects of memantine on phospholipid content and composition, membrane fluidity and β-adrenergic transmission. Pharmacol Toxicol 1993; 73: 202-8
    • (1993) Pharmacol Toxicol , vol.73 , pp. 202-208
    • Honegger, U.E.1    Quack, G.2    Wiesmann, U.N.3
  • 43
    • 0033846711 scopus 로고    scopus 로고
    • Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs
    • Ishizaki J, Yokogawa K, Ichimura F, et al. Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs. J Pharmacol Exp Ther 2000; 294 (3): 1088-98
    • (2000) J Pharmacol Exp Ther , vol.294 , Issue.3 , pp. 1088-1098
    • Ishizaki, J.1    Yokogawa, K.2    Ichimura, F.3
  • 44
    • 2642714342 scopus 로고
    • Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
    • Ohkuma S, Poole B. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc Natl Acad Sci U S A 1978; 75 (7): 3327-31
    • (1978) Proc Natl Acad Sci U S A , vol.75 , Issue.7 , pp. 3327-3331
    • Ohkuma, S.1    Poole, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.