Effect of risedronate on osteocyte viability and bone turnover in paired Iliac bone biopsies from early postmenopausal women

Calcified Tissue International

Volumn 87, Issue 5, 2010, Pages 392-397

  Qiu, S ^a   Phipps, R J ^b   Ebetino, F H ^c   Palnitkar, S ^a   Sudhaker Rao, D ^a  

^a HENRY FORD HOSPITAL   (United States)

^b HUSSON UNIVERSITY   (United States)

^c Warner Chilcott   (United States)

Author keywords

Bone biopsy; Bone turnover; Osteocyte; Postmenopausal women; Risedronate

Indexed keywords

PLACEBO; RISEDRONIC ACID;

ADULT; ARTICLE; BONE BIOPSY; BONE DEMINERALIZATION; BONE MINERALIZATION; BONE REMODELING; BONE TURNOVER; CELL VIABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; ILIAC BONE; OSSIFICATION; OSTEOCYTE; POSTMENOPAUSE; PRIORITY JOURNAL; SURFACE PROPERTY; TRABECULAR BONE; TREATMENT DURATION;

BONE DENSITY CONSERVATION AGENTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ETIDRONIC ACID; FEMALE; HUMANS; ILIUM; MIDDLE AGED; OSTEOCYTES; OSTEOPOROSIS, POSTMENOPAUSAL; TREATMENT OUTCOME;

EID: 78650177402     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9411-y     Document Type: Article

References (35)

1. E Seeman PD Delmas 2006 Bone quality-the material and structural basis of bone strength and fragility N Engl J Med 354 2250 2261 1:CAS:528: DC%2BD28XkvVShsbw%3D 10.1056/NEJMra053077 16723616
2. K Ikeda 2008 Osteocytes in the pathogenesis of osteoporosis Geriatr Gerontol Int 8 213 217 10.1111/j.1447-0594.2008.00481.x 19149831
3. CA O'Brien D Jia LI Plotkin T Bellido CC Powers SA Stewart SC Manolagas RS Weinstein 2004 Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength Endocrinology 145 1835 1841 10.1210/en.2003-0990 14691012 (Pubitemid 38402392)
4. NE Lane W Yao M Balooch RK Nalla G Balooch S Habelitz JH Kinney LF Bonewald 2006 Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice J Bone Miner Res 21 466 476 1:CAS:528:DC%2BD28XisFGqurY%3D 10.1359/JBMR.051103 16491295
5. RM Dillaman RD Roer DM Gay 1991 Fluid movement in bone: theoretical and empirical J Biomech 24 163 177 10.1016/0021-9290(91)90386-2 1791176
6. EH Burger J Klein-Nulend 1999 Mechanotransduction in bone-role of the lacuno-canalicular network FASEB J 13 S101 S112 1:CAS:528:DyaK1MXjtFGku7c%3D 10352151
7. L Wang C Ciani SB Doty SP Fritton 2004 Delineating bone's interstitial fluid pathway in vivo Bone 34 499 509 10.1016/j.bone.2003.11.022 15003797 (Pubitemid 38314914)
8. L Fosse H Ronningen P Benum RB Sandven 2006 Influence of water and fat content on compressive stiffness properties of impacted morsellized bone: an experimental ex vivo study on bone pellets Acta Orthop 77 15 22 10.1080/17453670610045641 16534697 (Pubitemid 43879149)
9. HM Frost 1960 Micropetrosis J Bone Joint Surg Am 42 144 150 13849862
10. S Qiu DS Rao S Palnitkar AM Parfitt 2002 Microdamage and missing osteocytes in human rib cortices are spatially associated and occur preferentially in interstitial bone J Bone Miner Res 17 946
11. FJ O'Brien D Taylor T Clive Lee 2005 The effect of bone microstructure on the initiation and growth of microcracks J Orthop Res 23 475 480 10.1016/j.orthres.2004.08.005 15734265 (Pubitemid 40287878)
12. S Qiu DS Rao S Palnitkar AM Parfitt 2003 Reduced iliac cancellous osteocyte density in patients with osteoporotic vertebral fracture J Bone Miner Res 18 1657 1663 10.1359/jbmr.2003.18.9.1657 12968675 (Pubitemid 37022924)
13. RS Weinstein SC Manolagas 2000 Apoptosis and osteoporosis Am J Med 108 153 164 1:STN:280:DC%2BD3M%2Fns1GrtQ%3D%3D 10.1016/S0002-9343(99)00420-9 11126309 (Pubitemid 30064426)
14. A Tomkinson J Reeve RW Shaw BS Noble 1997 The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone J Clin Endocrinol Metab 82 3128 3135 1:CAS:528:DyaK2sXlvFemtbc%3D 10.1210/jc.82.9.3128 9284757 (Pubitemid 27385687)
15. A Tomkinson EF Gevers JM Wit J Reeve BS Noble 1998 The role of estrogen in the control of rat osteocyte apoptosis J Bone Miner Res 13 1243 1250 1:CAS:528:DyaK1cXlsFWrsLg%3D 10.1359/jbmr.1998.13.8.1243 9718192 (Pubitemid 28373325)
16. LI Plotkin SC Manolagas T Bellido 2006 Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs Bone 39 443 452 1:CAS:528: DC%2BD28XotFyksLg%3D 10.1016/j.bone.2006.02.060 16627025 (Pubitemid 44164640)
17. LI Plotkin V Lezcano J Thostenson RS Weinstein SC Manolagas T Bellido 2008 Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo J Bone Miner Res 23 1712 1721 1:CAS:528:DC%2BD1cXhtlGlu7zP 10.1359/jbmr.080617 18597631
18. LI Plotkin RS Weinstein AM Parfitt PK Roberson SC Manolagas T Bellido 1999 Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin J Clin Invest 104 1363 1374 1:CAS:528:DyaK1MXntlyru7k%3D 10.1172/JCI6800 10562298
19. H Follet J Li RJ Phipps S Hui K Condon DB Burr 2007 Risedronate and alendronate suppress osteocyte apoptosis following cyclic fatigue loading Bone 40 1172 1177 1:CAS:528:DC%2BD2sXjtVaktrw%3D 10.1016/j.bone.2006.12.052 17240209 (Pubitemid 46386562)
20. S Qiu DS Rao S Palnitkar AM Parfitt 2002 Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone Bone 31 313 318 1:STN:280:DC%2BD38vkvFKrtw%3D%3D 10.1016/S8756-3282(02)00819-0 12151084 (Pubitemid 34822826)
21. HW van Essen PJ Holzmann MA Blankenstein P Lips N Bravenboer 2007 Effect of raloxifene treatment on osteocyte apoptosis in postmenopausal women Calcif Tissue Int 81 183 190 1:CAS:528:DC%2BD2sXpvF2rtbk%3D 10.1007/s00223-007-9050-0 17676256 (Pubitemid 47373354)
22. JM Gidday 2006 Cerebral preconditioning and ischaemic tolerance Nat Rev Neurosci 7 437 448 1:CAS:528:DC%2BD28Xkslelu7c%3D 10.1038/nrn1927 16715053 (Pubitemid 44012284)
23. HT Sommerschild KA Kirkeboen 2002 Preconditioning-endogenous defence mechanisms of the heart Acta Anaesthesiol Scand 46 123 137 1:CAS:528: DC%2BD38XktF2qtr4%3D 10.1034/j.1399-6576.2002.460202.x 11942859 (Pubitemid 34250773)
24. AM Parfitt 1993 Bone age, mineral density, and fatigue damage Calcif Tissue Int 53 S82 S86 10.1007/BF01673408 8275385
25. EF Eriksen F Melsen E Sod I Barton A Chines 2002 Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis Bone 31 620 625 1:CAS:528:DC%2BD38XptlGisrk%3D 10.1016/S8756- 3282(02)00869-4 12477578 (Pubitemid 35449706)
26. PM Chavassieux ME Arlot C Reda L Wei AJ Yates PJ Meunier 1997 Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis J Clin Invest 100 1475 1480 1:CAS:528:DyaK2sXmt1Cqsb8%3D 10.1172/JCI119668 9294113
27. RR Recker PD Delmas J Halse IR Reid S Boonen PA Garcia-Hernandez J Supronik EM Lewiecki L Ochoa P Miller H Hu P Mesenbrink F Hartl J Gasser EF Eriksen 2008 Effects of intravenous zoledronic acid once yearly on bone remodeling and bone structure J Bone Miner Res 23 6 16 1:CAS:528: DC%2BD1cXhtVCmt7c%3D 10.1359/jbmr.070906 17892374
28. RS Weinstein PK Roberson SC Manolagas 2009 Giant osteoclast formation and long-term oral bisphosphonate therapy N Engl J Med 360 53 62 1:CAS:528:DC%2BD1MXhvF2juw%3D%3D 10.1056/NEJMoa0802633 19118304
29. A Boyde 2003 The real response of bone to exercise J Anat 203 173 189 10.1046/j.1469-7580.2003.00213.x 12924818 (Pubitemid 36974662)
30. S Qiu D Sudhaker Rao DP Fyhrie S Palnitkar AM Parfitt 2005 The morphological association between microcracks and osteocyte lacunae in human cortical bone Bone 37 10 15 10.1016/j.bone.2005.01.023 15878702 (Pubitemid 40848412)
31. MA Fernandez-Seara SL Wehrli M Takahashi FW Wehrli 2004 Water content measured by proton-deuteron exchange NMR predicts bone mineral density and mechanical properties J Bone Miner Res 19 289 296 10.1359/JBMR.0301227 14969399 (Pubitemid 38116743)
32. P Roschger EP Paschalis P Fratzl K Klaushofer 2008 Bone mineralization density distribution in health and disease Bone 42 456 466 1:STN:280: DC%2BD1c7itVCrtw%3D%3D 10.1016/j.bone.2007.10.021 18096457
33. Ascenzi MG, Kabo JM (2007) Method and system for modelling bone structure. Patent
34. AI Prentice 1967 Autofluorescence of bone tissues J Clin Pathol 20 717 719 1:STN:280:DyaF1M%2FjvVGqsw%3D%3D 10.1136/jcp.20.5.717 5602982
35. O Akkus A Polyakova-Akkus F Adar MB Schaffler 2003 Aging of microstructural compartments in human compact bone J Bone Miner Res 18 1012 1019 1:CAS:528:DC%2BD3sXkslOhsb4%3D 10.1359/jbmr.2003.18.6.1012 12817753 (Pubitemid 37294937)